Patterns of failure following loco-regional radiotherapy in the treatment of limited stage small cell lung cancer

Coy, Peter; Hodson, D. Ian; Murray, Nevin; Peter, Joseph L.; Payne, David G.; Arnold, Andrew; Kostashuk, E.; Dixon, Peter; Evans, William K.; Zee, Benny; Sadura, Anna; Ayoub, Joseph; Levitt, Martin; Wierzbicki, Rafal; Feld, Ronald; Maroun, J.; Wilson, Kenneth S.

doi:10.1016/0360-3016(94)90058-2

Cited by 22 publications

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“…Clinical trials have demonstrated that distant control can be corrected by improving local treatment ( 22 , 26 ). Importantly, patients treated with early CCRT had a lower incidence of subsequent BM ( 27 , 28 ). Therefore, CCRT can directly improve the therapeutic effect of the primary tumor and indirectly reduce the incidence of distant metastasis in patients.…”

Section: Discussionmentioning

confidence: 99%

A New Nomogram and Risk Stratification of Brain Metastasis by Clinical and Inflammatory Parameters in Stage III Small Cell Lung Cancer Without Prophylactic Cranial Irradiation

Qiu

et al. 2022

Front. Oncol.

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BackgroundThis study was conducted to determine risk factors for developing brain metastasis (BM) and to predict brain metastasis free survival (BMFS) and overall survival (OS) by combining several clinical parameters and inflammatory indexes.Materials and MethodsA nomogram and risk stratification were developed based on multivariate analysis results. The prognostic index (PI) predicting the high risk of BM was calculated by multiplying the weighted factor (β coefficient) with each variable.ResultsThirty-two of one hundred patients (32.0%) developed BM. Multivariate cox regression analysis revealed that concurrent chemoradiotherapy (CCRT; hazard ratio (HR), 3.356; p = 0.020), monocyte–lymphocyte ratio (MLR; HR, 4.511; p = 0.002), neutrophil–lymphocyte ratio (NLR; HR, 4.023; p = 0.033), and prognostic-nutrition index (PNI; HR, 2.902; p = 0.018) were independent prognostic factors of BMFS. The nomogram has good accuracy in predicting BMFS, and the C-index was 0.73. The ROC curve showed that these risk factors have good discriminant ability. Similarly, tumor location (HR, 1.675; p = 0.035) and MLR (HR, 2.076; p = 0.013) were independent prognostic factors of OS. In the subgroup analysis of OS, the good group had a better prognosis than the other groups. Risk stratification by PI: the high-risk group had worse BMFS than the low-risk group, which also has certain practical significance for clinical practice in OS.ConclusionWe developed a nomogram and corresponding risk stratification in stage III SCLC patients who developed BM. This model and risk stratification can help clinicians improve patient treatment management and better deliver personalized therapy.

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Section: Discussionmentioning

confidence: 99%

A New Nomogram and Risk Stratification of Brain Metastasis by Clinical and Inflammatory Parameters in Stage III Small Cell Lung Cancer Without Prophylactic Cranial Irradiation

Qiu

et al. 2022

Front. Oncol.

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“…About 30 years ago, a randomized study by the British Medical Research Council [1] concluded that radiotherapy alone for LD was superior to surgery. However, the local recurrence rate after radiation therapy alone subsequently was reported to be 18% to 69% [2]. The Veterans Administration Surgery Oncology Group [3] reviewed data on 148 resected SCLCs to evaluate the role of adjuvant chemotherapy in nonsmall cell lung cancers (NSCLCs) and reported a 59.5 % 5-year survival rate for stage IA disease.…”

Section: Introductionmentioning

confidence: 99%

Outcome of Surgery for Small Cell Lung Cancer - Response to Induction Chemotherapy Predicts Survival

Nakamura

Kato

2004

Thorac cardiovasc Surg

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Thoraxorgane

Debus¹

Strahlentherapie

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Patterns of failure following loco-regional radiotherapy in the treatment of limited stage small cell lung cancer

Cited by 22 publications

References 17 publications

A New Nomogram and Risk Stratification of Brain Metastasis by Clinical and Inflammatory Parameters in Stage III Small Cell Lung Cancer Without Prophylactic Cranial Irradiation

A New Nomogram and Risk Stratification of Brain Metastasis by Clinical and Inflammatory Parameters in Stage III Small Cell Lung Cancer Without Prophylactic Cranial Irradiation

Outcome of Surgery for Small Cell Lung Cancer - Response to Induction Chemotherapy Predicts Survival

Thoraxorgane

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