This paper highlights the relationships between the formation of shear zones, associated quartz-rich veins and their quartz-depleted alteration haloes ('episyenites') that have formed in the Mont Blanc Massif during the Alpine orogeny. The shear zones are steeply dipping and formed late (18-13 Ma) during collisional orogeny, at mid-crustal depths (5 + 1 kbar, 400 + 50 ~ during uplift of the Mont Blanc Massif. Between the shear zones, nearly undeformed granite contains widely dispersed, subhorizontal veins with a quartz-dominant quartz + albite + chlorite + adularia assemblage. They do not intersect the shear zones and are surrounded by quartz-depleted alteration haloes up to several metres wide. The compositions of the shear zones and the vein-alteration haloes (episyenites) show substantial departures from the bulk composition of the host rock. Shear zones are characterized by greenschist facies assemblages (epidote-, chlorite-or K-white-micabearing assemblages). Each shear zone type is featured by a specific chemical change: depletions in K20, and enrichments in Fe203 and CaO (epidote-); with depletions in CaO, Na20, K20 and slight SiO2 enrichments (white mica-chlorite-); with depletions in SiO2, CaO, Na20, K20 and enrichments in MgO (phlogopite-chlorite shear zones). Episyenites are characterized by chemically induced porosity enhancement due to dissolution of magmatic quartz and biotite, with subsequent partial infilling of pore spaces by quartz, chlorite, albite and adularia. The vein arrays have accommodated minor vertical stretching in the Mont Blanc Massif, probably at the same time as the adjacent shear zones were accommodating more substantial vertical stretching in the massif. Coupled quartz dissolution in the wallrock alteration haloes and quartz precipitation in veins could be interpreted to reflect local mass transfer between wallrock and veins during essentially closed-system behaviour in the relatively undeformed granite domains between shear zones. In contrast, shear zones probably develop in opened systems due to their kilometric length.Studies of fluid-rock interaction processes during deformation in metamorphic rock provide insights about fluid circulation in the middle-lower continental crust. It also provides constraints to estimate the magnitude of mass transfer during orogenic events. Mass balance calculations during fluid-rock interaction are easier when based on rocks of homogeneous composition at regional scale. This is rather common in many granitic massifs and therefore granitic rocks are good candidates for such studies.In metamorphosed granites, fluid-rock interactions are mainly localized along shear zones,