Patterns of Gustatory Recovery in Patients Affected by the COVID-19 Outbreak

Chiesa‐Estomba, Carlos Miguel; Lechien, Jérôme R.; Barillari, Maria Rosaria; Saussez, Sven

doi:10.1007/s12250-020-00272-9

Cited by 19 publications

(17 citation statements)

References 14 publications

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“…Even if one month passed after the disappearance of fever and dyspnea, ageusia still persisted in 11.5% of French patients [ 94 ]. In a study of European multiple sites, 9.4% of patients reported gustatory dysfunction after a mean follow-up of 63 days from the first consultation [ 96 ]. A longitudinal study showed that taste alteration of Israeli patients lasts long with the mean duration of 17.2 days [ 113 ].…”

Section: Gustatory Dysfunctionmentioning

confidence: 99%

Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review

Tsuchiya

2021

Dentistry Journal

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Since the worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, management of coronavirus disease 2019 (COVID-19) has been challenging for healthcare providers. The oral cavity is referred to as a target of SARS-CoV-2. The aim of this study was to review oral symptoms specific to COVID-19 patients from the point of view of symptom prevalence and pathogenesis and to speculate the pathogenic mechanisms underlying them. Scientific articles were retrieved by searching PubMed/MEDLINE, Google Scholar, medRxiv, and bioRxiv from 3 February 2020 to 31 December 2020, and they were reviewed by title, abstract, and text for relevance. The literature search indicated that COVID-19 patients frequently present with gustatory dysfunction, xerostomia, and oral mucosal lesions, while their prevalence is likely to vary by country, age, gender, and disease severity. Gustatory dysfunction and xerostomia appear at an early stage of SARS-CoV-2 infection and last relatively long. One of possible pathogenic mechanisms of both symptoms is attributed to the expression of viral cellular entry-relevant receptors in taste cells and salivary glands. Dental professionals who can first become aware of oral symptoms associated with COVID-19 will play a more active role in and make a greater contribution to diagnosis and prevention of COVID-19.

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Section: Gustatory Dysfunctionmentioning

confidence: 99%

Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review

Tsuchiya

2021

Dentistry Journal

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“…Studies reporting clinical characteristics persisting after acute SARS‐CoV‐2 infection comprised one case–control study 32 and 18 case‐series studies 7,26–31,33–43 . Median study sample size was 100 (range 20–701, interquartile range 41.5–124).…”

Section: Resultsmentioning

confidence: 99%

“…Of the 18 case‐series studies, 10 reported solely on patients who had required hospitalization for COVID‐19 7,27–30,34,36,37,41,43 . The remainder reported on either mixed populations of patients who had required inpatient or outpatient management for past acute COVID‐19, 26,35,39,42 solely outpatients, 33,38,40 or did not report if hospital admission had been required 31 . Case‐series studies only of patients who had required hospitalization (Table 3), reported a wider range of clinical characteristics compared to those reported in studies of mixed patient populations (Table 4).…”

Section: Resultsmentioning

confidence: 99%

“…Abnormal pulmonary investigation or imaging findings were reported in five studies 27,34,36,41,43 . Issues with smell and taste were reported at rates of 11–45% 7,28,31,39 and 7–11%, 7,26,28,36,39 respectively, within individual study populations, with one study describing issues with smell and/or taste in 39% of participants 33 . Other symptoms of potential neurological origin included headache, reported in 4–50% of participants 7,36,39,40 ; memory issues, reported in 5–34% of participants 28,39 ; and attention disorder, in 1–27% of participants 28,39 .…”

Section: Resultsmentioning

confidence: 99%

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Proposed delay for safe surgery after COVID‐19

Kovoor

Scott

Tivey

et al. 2021

ANZ Journal of Surgery

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Background Long‐term effects after COVID‐19 may affect surgical safety. This study aimed to evaluate the literature and produce evidence‐based guidance regarding the period of delay necessary for adequate recovery of patients following COVID‐19 infection before undergoing surgery. Methods A rapid review was combined with advice from a working group of 10 clinical experts across Australia and New Zealand. MEDLINE, medRxiv and grey literature were searched to 4 October 2020. The level of evidence was stratified according to the National Health and Medical Research Council evidence hierarchy. Results A total of 1020 records were identified, from which 20 studies (12 peer‐reviewed) were included. None were randomized trials. The studies comprised one case–control study (level III‐2 evidence), one prospective cohort study (level III‐2) and 18 case‐series studies (level IV). Follow‐up periods containing observable clinical characteristics ranged from 3 to 16 weeks. New or excessive fatigue and breathlessness were the most frequently reported symptoms. SARS‐CoV‐2 may impact the immune system for multiple months after laboratory confirmation of infection. For patients with past COVID‐19 undergoing elective curative surgery for cancer, risks of pulmonary complications and mortality may be lowest at 4 weeks or later after a positive swab. Conclusion After laboratory confirmation of SARS‐CoV‐2 infection, minor surgery should be delayed for at least 4 weeks and major surgery for 8–12 weeks, if patient outcome is not compromised. Comprehensive preoperative and ongoing assessment must be carried out to ensure optimal clinical decision‐making.

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“…Most cohorts were from Europe (n=40), followed by Middle East (n=8), North and South America (n=6 and n=2, respectively), East Asia (n=6) and Africa (n=1). Two articles (Lechien et al, 2020a; 2020b) pooled multinational data within Europe, whereas three studies (Chiesa-Estomba et al, 2020a; Menni et al, 2020; Qiu et al, 2020) included cases from two main geographical areas. Study populations and prevalence range are graphically depicted in Figure 2 .…”

Section: Resultsmentioning

confidence: 99%

Taste alteration in COVID-19: a rapid review with data synthesis reveals significant geographical differences

Cirillo

2020

Preprint

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To facilitate a timely understanding of the differences in the prevalence of gustatory disturbances (GD) in individuals infected with SARS-CoV-2, we undertook a rapid systematic review of articles published in the repository of the National Library of Medicine (MEDLINE/PubMed) and medRxiv from their inception until September 3, 2020. The minimum requirements for completing a restricted systematic review were met. Of the 431 articles retrieved, 61 eligible studies (28,374 confirmed COVID-19 cases) from 20 countries were included in the analysis. The results show strong significant differences in the overall reported prevalence of GD between East Asia [13%, 95% CI 0.14-26.06%], Middle East [38.83%, 95% CI 27.47-50.19%], Europe [57.18%, 95% CI 52.35-62.01%], and The Americas [66.78%, 95% CI 54.77-78.79%]. There were no trends showing differences of prevalence of GD in the available literature between February and August,, 2020. These data show that there is a distinct geographical distribution of GD in COVID-19 patients and this may explain the differences of diagnostic criteria for COVID-19 case definition.

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Patterns of Gustatory Recovery in Patients Affected by the COVID-19 Outbreak

Cited by 19 publications

References 14 publications

Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review

Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review

Proposed delay for safe surgery after COVID‐19

Taste alteration in COVID-19: a rapid review with data synthesis reveals significant geographical differences

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