Patterns of Hair Growth Cycles in the Colored Rabbit and Their Modification by Experimental Means

Rony, Hugo R.; Cohen, David; Schaffner, BS Irving

doi:10.1038/jid.1953.109

Cited by 28 publications

(3 citation statements)

References 9 publications

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“…In the current study, we established an additional pigmented model for CIA, using the pigmented adult LE rat. We report that hair clipping of the telogen hair shafts, without removal of the entire hair shafts, was sufficient to induce synchronized anagen and subsequent CIA in young rats, a finding that, to our knowledge, has not been previously reported, although previous studies have shown that clipping can induce anagen in rabbits, 14 mice 15,16 and guinea pigs 17 . The effects of synchronized anagen were detectable as early as 4 days after clipping, and the HFs in the clipped areas had the typical HF dystrophy in response to chemotherapy.…”

Section: Discussionmentioning

confidence: 50%

A novel rat model for chemotherapy-induced alopecia

Wikramanayake¹,

Amini²,

Simon³

et al. 2012

Clinical and Experimental Dermatology

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Summary Background More than half of all people diagnosed with cancer receive chemotherapy, and approximately 65% of these develop chemotherapy-induced alopecia (CIA), a side-effect that can have considerable negative psychological repercussions. Currently, there are very few animal models available to study the mechanism and prevention of CIA. Aim To develop a clinically relevant adult rat model for CIA. Methods We first tested whether neonatal pigmented Long–Evans (LE) rats developed alopecia in response to the chemotherapeutic agents etoposide and cyclophosphamide. We then determined whether the rats developed CIA as adults. In the latter experiment, rat dorsal hair was clipped during the early telogen stage to synchronize the hair cycle. and starting 15 days later, the rats were treated with etoposide for 3 days. Results Neonatal LE pups developed CIA in response to etoposide and cyclophosphamide, similar to other murine models for CIA. Clipping of the hair shaft during early telogen resulted in synchronized anagen induction and subsequent alopecia after etoposide treatment in the clipped areas only. Hair follicles in the clipped areas had the typical chemotherapy-induced follicular dystrophy (dystrophic catagen). When the hair in the pigmented alopecic areas regrew, it had normal pigmentation. Conclusions A novel, pigmented adult rat model has been established for CIA. By hair shaft clipping during early telogen, synchronized anagen entry was induced that resulted in alopecia in response to chemotherapy. This is the first clinically relevant adult rat model for CIA and will be a useful tool to test agents for the prevention and treatment of CIA.

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Section: Discussionmentioning

confidence: 50%

A novel rat model for chemotherapy-induced alopecia

Wikramanayake¹,

Amini²,

Simon³

et al. 2012

Clinical and Experimental Dermatology

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“…The fact that the artificially induced hair growth is not distinguishable histologically from normal hair growth has also been reported by Rony et al (1953) in studies on the rabbit.…”

Section: Discussionmentioning

confidence: 61%

INFLUENCE OF CLIPPING AND CHEMICAL EPILATION ON HAIR GROWTH IN MICE¹

Borum¹

1958

Acta Pathologica Microbiologica Scandinavica

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“…Animals. Female New Zealand white rabbits (2-3 kg wt) were clipped dorsally on a Friday for use the following Monday, only rabbits free of hair growth being used (see Rony, Cohen & Schaffner, 1953;and Chase, 1954 for information on hair growth cycles). During patch testing the rabbits were held in restraincr boxes.…”

Section: Methodsmentioning

confidence: 99%

Patch testing in the rabbit using a modified human patch test method.

Ingram

Grasso

1975

Br J Dermatol

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A 5 h, semi-occlusive human patch test repeated daily for 5 days, was modified for use in the rabbit Using this method, the relative irritancy of three cosmetic samples of known human irritancy was determined in the rabbit. In addition, attention was paid to assessment methods and a detailed histological scoring system is described as well as two methods of visual assessment. In order to compare the effectiveness of these methods, the reaction to a series of concentrations of sodium lauryl sulphate was examined. All three assessment methods gave similar results and the merits of combining histological and visual assessment are discussed.

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Patterns of Hair Growth Cycles in the Colored Rabbit and Their Modification by Experimental Means

Cited by 28 publications

References 9 publications

A novel rat model for chemotherapy-induced alopecia

A novel rat model for chemotherapy-induced alopecia

INFLUENCE OF CLIPPING AND CHEMICAL EPILATION ON HAIR GROWTH IN MICE¹

Patch testing in the rabbit using a modified human patch test method.

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Patterns of Hair Growth Cycles in the Colored Rabbit and Their Modification by Experimental Means

Cited by 28 publications

References 9 publications

A novel rat model for chemotherapy-induced alopecia

A novel rat model for chemotherapy-induced alopecia

INFLUENCE OF CLIPPING AND CHEMICAL EPILATION ON HAIR GROWTH IN MICE1

Patch testing in the rabbit using a modified human patch test method.

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INFLUENCE OF CLIPPING AND CHEMICAL EPILATION ON HAIR GROWTH IN MICE¹