Patterns of Hepatitis B, Hepatitis C and HIV Among Blood Donors in Samtah-Jazan Region

Abstract

Background and Objective Transfusion-transmitted infectious agents are amongst the major health burden worldwide. The purpose of this study was to evaluate the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) among blood donors in Samtah General Hospital, Jazan region, Saudi Arabia. Material and Methods In this retrospective study, blood donation records of all blood donors recruited between January 2019 and August 2020 were included for data acquisition. A total of 4977 blood donors’ records were reviewed and data were analysed. Results Hepatitis B profile showed 0.60% blood donors positive for hepatis B surface antigen (HBsAg). Nucleic acid testing (NAT) showed the presence of HBV-DNA in 0.4% of the blood donors. Anti-HBs and anti-HBc antibodies were reactive in 3.34% and 7.31% blood donors’ units, respectively. Anti-HCV antibodies were reactive among 54 (1.09%) blood donors. Upon reviewing the NAT analysis results, 0.16% (08) blood donors showed the presence of HCV-RNA in their blood units. Anti-HIV antibodies were reactive in 8 (0.16%) blood donors. Conclusion It is concluded that the frequency of HBsAg is comparatively lower while anti-HCV positivity is higher in Samtah, Jazan as a region compared to other regions of the country. Further studies are warranted to evaluate the cause of HCV infection in this area. Frequency of HIV is uncommon in this area.

Association of ABO, Rh-D and Kell blood groups with transfusion transmitted infections among blood donors from the Asir Region, Saudi Arabia

“…Prior studies from Saudi Arabia have identified HBV as the most common TTI. 13 , 15 , 22 , 25 In addition, studies from North India, Northwest Ethiopia, Jordan, Pakistan, and Turkey have all found HBV to be the predominantly observed TTI among participants. 4 , 8 , 11 , 17 , 26 Thus, our finding is consistent with previously published data.…”

Seroprevalence of Hepatitis C Virus Among Blood Donors in a Tribal-Preponderant Region of India

“…As compared to our study, the seroprevalence of HCV was reported in blood donors in other parts of India by Garg et al (0.28%) from western India [ 26 ], Mandal et al (0.62%) from Darjeeling [ 35 ], Jindal et al (1.76%) from north India [ 36 ], Saini et al (0.07%) from Indore [ 33 ], Mukherjee et al (0.044%) from western Odisha [ 37 ], Shaiji et al (0.72%) from Trivandarum [ 38 ], Meena et al (0.57%) from Delhi [ 39 ], Pahuja et al (0.66%) from Delhi [ 22 ], Kaur et al (2.44%) from North India [ 29 ], Afrose et al (0.22%) from Aligarh [ 40 ], Ryhan et al (0.22%) from Srinagar [ 32 ], Shah et al (0.33%) from Ahmedabad [ 34 ], Gupta et al (1.45%) from Ludhiana [ 41 ], Bagde et al (0.065%) from Rajnandgaon, Chhattisgarh [ 42 ], Pawan et al (0.50%) from Delhi [ 25 ], Sawke et al (0.57%) from Bhopal [ 43 ], Patel et al (0.14%) from Gujarat India [ 44 ], and Dhariwal et al (0.71%) from Rajasthan [ 31 ]. However, reported seroprevalence of HCV in countries other than India was given by Abebe et al (0.64%) from Western Oromia, Ethiopia [ 45 ], Mobarki et al (1.09%) from Jazan region of Saudi Arabia [ 46 ], Ahmed et al (1.75%) from Karachi, Pakistan [ 47 ], and Alharazi et al (2.0%) from Sana’a, Yemen [ 48 ]. The higher prevalence of hepatitis C in apparently healthy blood donors in our study can be explained by the fact that persists in abundance in our society.…”

Red Cell Alloimmunisation Among Sickle Cell Disease and Thalassemia Patients Following Rh- and K-Matched Red Cell Transfusion in Southwestern Saudi Arabia: A Multicenter Study

“…21 In addition, it should be mentioned that a recent study reported that 55% of blood donors were Saudi and 45% otherwise among 4977 blood donors in Samtah-Jazan, which might impact the rate of alloimmunization in the region. 19,22 Furthermore, the incidence of A2 and A2B subgroups and anti-A1 antibody in the region has been linked to possible complications. 23 Hence, we sought to look the rate of alloimmunisation in SCD and thalassemia patients in different hospitals of Jazan region, thus will provide in depth data for the improvement of blood transfusion protocol among SCD and thalassemia and report the finding to health care provided for more attention.…”

“… 21 In addition, it should be mentioned that a recent study reported that 55% of blood donors were Saudi and 45% otherwise among 4977 blood donors in Samtah-Jazan, which might impact the rate of alloimmunization in the region. 19 , 22 Furthermore, the incidence of A2 and A2B subgroups and anti-A1 antibody in the region has been linked to possible complications. 23 …”