2007
DOI: 10.1200/jco.2007.25.18_suppl.2533
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Patterns of HER-family receptor dimerization in trastuzumab susceptible and trastuzumab resistant cell lines

Abstract: 2533 Background: HER2 overexpression is associated with accelerated disease progression and poor prognosis in breast cancer. Trastuzumab, a monoclonal antibody targeting the extracellular domain of HER2, is effective in the treatment of metastatic breast cancer. However, most patients treated with trastuzumab eventually develop clinical resistance. To investigate the role of HER-family receptors in trastuzumab resistance, we measured HER-family receptor expression, dimerization, and phosphorylation in trastuz… Show more

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