Patterns of Injury in Mycophenolate Mofetil–Related Colitis

Al-Absi, Ahmed; Cooke, Colin R.; Wall, Barry M.; Sylvestre, Pamela B.; Ismail, Mohammad K.; Mya, Maung Maung

doi:10.1016/j.transproceed.2010.08.066

Cited by 49 publications

(42 citation statements)

References 12 publications

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“…Nausea, vomiting, abdominal discomfort and diarrhea are common complaints in patients taking MPA derivatives. Dividing the dose to a four times a day schedule may be helpful; however, more serious adverse GI effects as inflammatory bowel disease-like colitis and graft vs host disease-like enteropathy related to MPA have been reported [61,62] . MPA seems to have a protective effect against post transplant de novo malignancies and when included in immunosuppression regimens may increase the time to develop malignancies [63] , however, MPA was not shown to be effective in prevention of post liver transplant recurrence of HCC [64] .…”

Section: Maintenance Immunosuppressionmentioning

confidence: 99%

Review on immunosuppression in liver transplantation

Moini

Schilsky

Tichy

2015

WJH

203

159

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Section: Maintenance Immunosuppressionmentioning

confidence: 99%

Review on immunosuppression in liver transplantation

Moini

Schilsky

Tichy

2015

WJH

203

159

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“…Symptoms and histopathologic abnormalities may improve when mycophenolate mofetil is substituted with another immunosuppressive drug. [13][14][15] In summary, the present kidney transplant recipient had acute colonic pseudo-obstruction that persisted despite several commonly used treatments. He improved only after discontinuation of mycophenolate mofetil.…”

Section: Discussionmentioning

confidence: 74%

Untitled

Al-Mueilo

Alsulaiman²

2015

Exp Clin Transplant

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Mycophenolate mofetil is a component of immunosuppressive regimens in solid-organ transplant recipients. Gastrointestinal symptoms such as nausea, abdominal pain, and diarrhea without fever are common in patients treated with mycophenolate mofetil. We treated a patient who had acute colonic pseudo-obstruction after kidney transplant that resolved after discontinuing mycophenolate mofetil. The disorder recurred soon after resuming mycophenolate mofetil, which is evidence for an association between mycophenolate mofetil and acute colonic pseudo-obstruction in this patient.

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“…In several patients, aspects amenable to graft-vs-host-disease were detected. However, not less importantly, a Crohn's-like disease was also consistently observed (17). The causal involvement of mycophenolate in these changes was suggested by repair upon withdrawal.…”

Section: Micophenolatementioning

confidence: 88%

The Changing Face of Inflammatory Bowel Disease: Etiology, Physiopathology, Epidemiology

Actis

2016

Ann Colorectal Res

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Context: The term inflammatory bowel disease (IBD) classically includes ulcerative colitis (UC) and Crohn's disease (CD). An abnormally increased mucosal permeability seems to underlie UC, whereas CD is thought to be the result of an immune deficiency state. Evidence Acquisition: While these phenomena may well be labeled as genetic factors, the environment has its role as well. Drugs (chiefly, antibiotics and non-steroidal anti-inflammatory molecules, with proton pump inhibitors recently joining the list) and smoking habits are all being scrutinized as IBD causative factors. Results: Once almost unknown, the prevalence of IBD, in the Eastern World and China, is now increasing by manifold, therefore arousing warning signals. Conclusions:A multidisciplinary approach will soon be necessary, to face the tenacious behavior of IBD, on a global perspective.

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Patterns of Injury in Mycophenolate Mofetil–Related Colitis

Cited by 49 publications

References 12 publications

Review on immunosuppression in liver transplantation

Review on immunosuppression in liver transplantation

Untitled

The Changing Face of Inflammatory Bowel Disease: Etiology, Physiopathology, Epidemiology

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