Patterns of interruption of atrial flutter induced by rapid atrial pacing.

SummaryPhysiological and pathological aging of the central nervous system (CNS) is characterized by functional neuronal impairments which may lead to perturbed cell homeostasis and eventually to neuronal death. Many toxic events may underlie age-related neurodegeneration. These include the effects of beta amyloid, Tau and mutated presenilin proteins, free radicals and oxidative stress, pro-inflammatory cytokines and lack of growth factor support, which can be individually or collectively involved. Taken individually, these toxicants can induce very diverse cell responses, thus requiring individually targeted corrective interventions upstream of common cell death (apoptotic) pathways. Recent preliminary evidence suggests that the proinflammatory cytokine tumour necrosis factor alpha (TNF α α α α ) and growth factor withdrawal can both activate a common apoptotic pathway in nerve growth factor (NGF)-responsive PC12 cells involving caspase 3, albeit through very distinct upstream pathways: the former through active signalling and the latter through passive or lack of survival signalling. Here, we show that NGF can rescue PC12 cells from both growth factor withdrawaland TNF α α α α -promoted cell death. However, NGF rescue from growth factor withdrawal requires NGF signalling through the high-affinity tyrosine kinase receptor (TrkA), while NGF rescue from TNF α α α α -promoted cell death requires NGF signalling through the low-affinity p75NTR receptor. These results strengthen the idea that prevention of age-or pathology-associated neurodegeneration may require varied molecular approaches reflecting the diversity of the toxicants involved, possibly acting simultaneously.

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Tumour necrosis factor‐alpha‐ vs. growth factor deprivation‐promoted cell death: different receptor requirements for mediating nerve growth factor‐promoted rescue

Pappas

Decorti²,

Macdonald³

et al. 2003

Aging Cell

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Patterns of interruption of atrial flutter induced by rapid atrial pacing.

Cited by 1 publication

References 16 publications

Tumour necrosis factor‐alpha‐ vs. growth factor deprivation‐promoted cell death: different receptor requirements for mediating nerve growth factor‐promoted rescue

Tumour necrosis factor‐alpha‐ vs. growth factor deprivation‐promoted cell death: different receptor requirements for mediating nerve growth factor‐promoted rescue

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