Patterns of Intracellular Ca++ Distribution and Mobilization in Smooth Muscle

Weiss, George B.

doi:10.1007/978-1-4684-4328-8_8

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Assuming estimates of 25.5 thousand medical or surgical discharges with 123 130 000 annual patient-days nationally and extrapolating cost savings from this intervention, we project annual cost savings of $1.82 billion (direct cost savings $1.05 billion) set against projected total intervention costs of $20 million. We used the national average registered nurse hourly wage ($39.78) for this extrapolation, which results in lower intervention costs per 1000 patient-days than the weighted average hourly wage for registered nurses in Massachusetts and New York ($46.06)…”

Section: Resultsmentioning

confidence: 99%

Cost of Inpatient Falls and Cost-Benefit Analysis of Implementation of an Evidence-Based Fall Prevention Program

et al. 2023

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ImportanceThere is insufficient research on the costs of patient falls in health care systems, a leading source of nonreimbursable adverse events.ObjectiveTo report the costs of inpatient falls and the cost savings associated with implementation of an evidence-based fall prevention program.Design, Setting, and ParticipantsIn this economic evaluation, a matched case-control study used the findings from an interrupted time series analysis that assessed changes in fall rates following implementation of an evidence-based fall prevention program to understand the cost of inpatient falls. An economic analysis was then performed to assess the cost benefits associated with program implementation across 2 US health care systems from June 1, 2013, to August 31, 2019, in New York, New York, and Boston, Massachusetts. All adults hospitalized in participating units were included in the analysis. Data analysis was performed from October 2021 to November 2022.InterventionsEvidence-based fall prevention program implemented in 33 medical and surgical units in 8 hospitals.Main Outcomes and MeasuresPrimary outcome was cost of inpatient falls. Secondary outcome was the costs and cost savings associated with the evidence-based fall prevention program.ResultsA total of 10 176 patients who had a fall event (injurious or noninjurious) with 29 161 matched controls (no fall event) were included in the case-control study and the economic analysis (51.9% were 65-74 years of age, 67.1% were White, and 53.6% were male). Before the intervention, there were 2503 falls and 900 injuries; after the intervention, there were 2078 falls and 758 injuries. Based on a 19% reduction in falls and 20% reduction in injurious falls from the beginning to the end of the postintervention period, the economic analysis demonstrated that noninjurious and injurious falls were associated with cost increases of $35 365 and $36 776, respectively. The implementation of the evidence-based fall prevention program was associated with $14 600 in net avoided costs per 1000 patient-days.Conclusions and RelevanceThis economic evaluation found that fall-related adverse events represented a clinical and financial burden to health care systems and that the current Medicare policy limits reimbursement. In this study, costs of falls only differed marginally by injury level. Policies that incentivize organizations to implement evidence-based strategies that reduce the incidence of all falls may be effective in reducing both harm and costs.

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Section: Resultsmentioning

confidence: 99%

Cost of Inpatient Falls and Cost-Benefit Analysis of Implementation of an Evidence-Based Fall Prevention Program

et al. 2023

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“…The effects of endothelial integrity and threshold concentrations of ET‐1 on the vasoconstricting and spasmogenic effects of TEA were studied in guinea‐pig aorta rings. By blocking large conductance K + Ca channels ( Benham et al ., 1985 ), TEA induces depolarization in a variety of cells, including vascular smooth muscle ( Gillespie & Hutter, 1975 ; Inoue et al ., 1989 ; Tseng & Hoffman, 1989 ; Bonnet et al ., 1991 ), and increases the uptake of Ca 2+ ions through verapamil‐sensitive voltage‐dependent channels ( Haeusler, 1972 ; Weiss, 1983 ).…”

Section: Discussionmentioning

confidence: 99%

Endothelium is required in the vascular spasm induced by tetraethylammonium and endothelin‐1 in guinea‐pig aorta

Dorigo

Maragno

Santostasi

et al. 1999

British J Pharmacology

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1 To investigate the role of endothelium in vascular spasm, we studied the in¯uence of endothelin-1 (ET-1) on the contracting and spasmogenic e ect of the K + -channel blocker, tetraethylammonium (TEA), in aorta rings of reserpine-treated guinea-pigs, perfused with either control (5.5 mM) or elevated (50 mM) glucose concentration. 2 Endothelium-dependent relaxation induced by acetylcholine was lost in rings contracted by noradrenaline in the presence of elevated glucose. In control medium, TEA (1 ± 20 mM) induced a sustained tonic contraction, followed by a phasic spasm, characterized by rhythmic contractions. Elevated glucose, ET-1 (3 nM), or both, reduced the EC 50 of TEA-induced tonic contraction, without modifying the maximum contractile e ect. 3 In control medium, ET-1 reduced the time before TEA-induced spasm and increased the rate of rhythmic contractions. TEA-induced spasm was abolished by elevated glucose, and restored by ET-1. The spasm induced by TEA and ET-1 was ampli®ed by the ET A antagonist, EMD 94246 , and suppressed by the ET A -ET B antagonist, bosentan. In endothelium-denuded vessels incubated with high glucose and ET-1, TEA evoked only a tonic contraction. 4 In control medium, L-NAME (N G -nitro-L-arginine methyl ester) abolished TEA-induced rhythmic contractions. L-arginine, but not D-arginine, prevented the e ect of L-NAME. In the presence of elevated glucose and ET-1, TEA-induced spasm was not a ected by L-NAME, whereas verapamil, indomethacin, metyrapone, glybenclamide or apamin abolished the phasic spasm, unmasking the tonic contracture. 5 In conclusion, endothelium plays a regulatory role in the genesis and maintenance of TEAinduced rhythmic contractions, through the release endothelium derived relaxing factor and vasodilating eicosanoids.

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Cellular Mg++ Accumulation is Altered by Extracellular Na+ and Directly Affects Agonist-Induced Mobilization of Ca++ in Vascular Smooth Muscle

Shetty¹,

Zawadzki²,

Weiss³

1992

Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle

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Patterns of Intracellular Ca++ Distribution and Mobilization in Smooth Muscle

Cited by 3 publications

References 14 publications

Cost of Inpatient Falls and Cost-Benefit Analysis of Implementation of an Evidence-Based Fall Prevention Program

Cost of Inpatient Falls and Cost-Benefit Analysis of Implementation of an Evidence-Based Fall Prevention Program

Endothelium is required in the vascular spasm induced by tetraethylammonium and endothelin‐1 in guinea‐pig aorta

Cellular Mg++ Accumulation is Altered by Extracellular Na+ and Directly Affects Agonist-Induced Mobilization of Ca++ in Vascular Smooth Muscle

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