Patterns of malignancies in patients with HIV-AIDS: a single institution observational study

Haleshappa, Rudresha Antapura

doi:10.12788/jcso.0416

Cited by 2 publications

(2 citation statements)

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“…Common NADCs seen in other Indian studies had a similar pattern of incidence with Hodgkin's lymphoma, carcinoma anal canal, and head-neck cancers being the most common. [ 5 8 10 20 ]…”

Section: Discussionmentioning

confidence: 99%

Spectrum of malignancies among human immunodeficiency virus-infected patients at a tertiary level human immunodeficiency virus-anti-retroviral therapy center in a North Indian hospital

Arora¹,

Mahesh²,

Mahesh³

et al. 2021

Indian Journal of Sexually Transmitted Diseases and AIDS

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Introduction: Human immunodeficiency virus (HIV)-infected individuals have a higher risk of some types of cancer. A chronic immunodeficiency state, increased survival in the highly active antiretroviral therapy (HAART) era and predisposition to certain oncogenic viral infections have been postulated as the main reasons. While, the incidence of acquired immunodeficiency syndrome (AIDS) defining cancers (ADCs) is declining in the post-HAART era, non-AIDS-defining cancers (NADCs) are becoming an important cause of mortality in these patients. Materials and Methods: Analysis of the data of HIV-infected patients registered at an apex centre was done for 7 years. All patients were subjected to routine investigations on presentation (baseline) and during follow-up for the occurrence of any malignant disease. CD4 cell counts before starting anti-retroviral therapy and before the diagnosis of malignancy were noted. The date of the last review and the current status/outcome were recorded. Results: Out of 1258, 17 patients were diagnosed with various malignancies. Seven patients (41.2%) had ADCs and the remaining 10 (58.8%) had NADCs. The mean duration between diagnosis of HIV infection and diagnosis of malignancy was 59.53 months. The mean survival duration from the diagnosis of malignancy for all cases was 21 months. The mean survival duration was 29 months and 15 months for ADC and NADC group respectively. Conclusions: NADCs are on the rise in the era of effective use of HAART and increasing life span of HIV patients. The index of suspicion for cancer should be higher in such patients, especially compared to opportunistic infections in view of good immunovirologic status.

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“…Common NADCs seen in other Indian studies had a similar pattern of incidence with Hodgkin's lymphoma, carcinoma anal canal, and head-neck cancers being the most common. [ 5 8 10 20 ]…”

Section: Discussionmentioning

confidence: 99%

Spectrum of malignancies among human immunodeficiency virus-infected patients at a tertiary level human immunodeficiency virus-anti-retroviral therapy center in a North Indian hospital

Arora¹,

Mahesh²,

Mahesh³

et al. 2021

Indian Journal of Sexually Transmitted Diseases and AIDS

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“…The spectrum of HIV/AIDS-related malignancies in India differs from that reported in the Western literature [5910]. This difference may be due to the low prevalence of human herpesvirus 8 in the Indian population or to differential patterns of HIV transmission, with the heterosexual route the most common in India [11].…”

Section: Discussionmentioning

confidence: 99%

HIV/AIDS-related lymphoma: perspective from a regional cancer center in India

et al. 2019

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BackgroundIndia has the third largest population of people living with HIV/AIDS (PLHA). Lymphoma is the second most common malignancy among PLHA. However, data are lacking regarding HIV/AIDS-related lymphoma (ARL) in India. This study evaluated the epidemiology and clinical outcomes of ARL from a regional cancer center in India.MethodsThis retrospective analysis included cases of ARL between March 2011 and September 2017. Data were obtained from patient record files for the assessment of epidemiology and clinical outcomes. Statistical analysis was performed using GraphPad Prism 6. Comparisons of subtype-specific survivals were performed using log-rank tests.ResultsOf 1,226 lymphoma cases, 80 (6.5%) were ARL. Details were available for 70 patients. The median age at diagnosis was 40.5 (9–74) years with a male:female ratio of 2:1. AIDS-defining lymphomas (ADL) constituted 78.6% of cases, while 21.4% had non-AIDS defining lymphoma (NADL). The mean CD4 counts were 193.15±92.85 and 301.93±107.95 cells/µL, respectively (t-test; P=0.0002). Extranodal involvement was present in 55.7%, B symptoms were reported in 60%, and lactate dehydrogenase (LDH) was elevated in 64.3% of patients. The median overall survival times were 6 months for plasmablastic lymphoma (PBL), 23 months for diffuse large B-cell lymphoma (DLBCL), and was not reached for Hodgkin's lymphoma (log-rank test; P=0.0011). Other histological subtype cases were too few to draw meaningful survival outcomes.ConclusionARL is a heterogeneous disease. Histologic subtype is a major determinant of the clinical outcome. ADL has significantly lower CD4 counts than those of NADL. There is an urgent and unmet need for uniform management guidelines for improving outcomes in this under-represented patient population.

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Patterns of malignancies in patients with HIV-AIDS: a single institution observational study

Cited by 2 publications

References 20 publications

Spectrum of malignancies among human immunodeficiency virus-infected patients at a tertiary level human immunodeficiency virus-anti-retroviral therapy center in a North Indian hospital

Spectrum of malignancies among human immunodeficiency virus-infected patients at a tertiary level human immunodeficiency virus-anti-retroviral therapy center in a North Indian hospital

HIV/AIDS-related lymphoma: perspective from a regional cancer center in India

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