Patterns of Marijuana Use Among Patients With HIV/AIDS Followed in a Public Health Care Setting

Prentiss, Diane; Power, Rachel; Balmas, Gladys; Tzuang, Gloria; Israelski, Dennis

doi:10.1097/00126334-200401010-00005

Cited by 128 publications

(111 citation statements)

References 30 publications

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“…Surprisingly, this controversy is still unsettled. Indeed, although clinical trials of cannabis in affective disorders have yielded mixed results (7,8), many patients continue to report benefits from its use in primary or secondary depressive syndromes (9)(10)(11)(12)(13). One likely explanation for these contrasting data is suggested by the diversity of functions served by CB 1 receptors in the brain (14), which makes it difficult to separate the mood-elevating actions of ⌬ 9 -THC from its unwanted psychotropic effects.…”

mentioning

confidence: 99%

Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

Gobbi

Bambico

Mangieri

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

622

522

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Although anecdotal reports suggest that cannabis may be used to alleviate symptoms of depression, the psychotropic effects and abuse liability of this drug prevent its therapeutic application. The active constituent of cannabis, Delta(9)-tetrahydrocannabinol, acts by binding to brain CB, cannabinoid receptors, but an alternative approach might be to develop agents that amplify the actions of endogenous cannabinoids by blocking their deactivation. Here, we show that URB597, a selective inhibitor of the enzyme fatty-acid amide hydrolase, which catalyzes the intracellular hydrolysis of the endocannabinoid anandamide, exerts potent antidepressant-like effects in the mouse tail-suspension test and the rat forced-swim test. Moreover, URB597 increases firing activity of serotonergic neurons in the dorsal raphe nucleus and noradrenergic neurons in the nucleus locus ceruleus. These actions are prevented by the CB, antagonist rimonabant, are accompanied by increased brain anandamide levels, and are maintained upon repeated URB597 administration. Unlike direct CB, agonists, URB597 does not exert rewarding effects in the conditioned place preference test or produce generalization to the discriminative effects of Delta(9)-tetrahydrocannabinol in rats. The findings support a role for anandamide in mood regulation and point to fatty-acid amide hydrolase as a previously uncharacterized target for antidepressant drugs

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mentioning

confidence: 99%

Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

Gobbi

Bambico

Mangieri

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

622

522

View full text Add to dashboard Cite

show abstract

“…However, in our sample, smokers were less likely to use crack but and more likely to smoke marijuana. Although marijuana smoking for medicinal purposes remains controversial, evidence suggests that some HIV+ individuals believe that marijuana relieves some HIVrelated symptoms (Prentiss et al, 2004).Results also demonstrated an association between psychosocial factors and smoking. The odds of heavy smoking increased with lower levels of perceived social support.…”

mentioning

confidence: 77%

“…Marijuana use, in particular, is used at a high rate for recreational and medicinal purposes (Furler et al, 2004;Prentiss, Power, Balmas, Tzuang, & Israelski, 2004). Evidence linking any drug use and smoking in this population is mixed, with some research finding no relationship (Gritz et al, 2004) and others finding a positive relationship (Burkhalter et al, 2005).…”

Section: High Smoking Prevalence Among Hiv+ Men and Women: Examining mentioning

confidence: 99%

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Cigarette Smoking among HIV+ Men and Women: Examining Health, Substance Use, and Psychosocial Correlates across the Smoking Spectrum

et al. 2007

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The prevalence of cigarette smoking among HIV+ individuals is greater than that found in the general population. However, factors related to smoking within this population are not well understood. This study examined the associations between smoking and demographic, medical, substance use, and psychosocial factors in a clinic-based sample of HIV+ men and women. Two hundred twelve participants completed self-report measures of tobacco use, HIV-related symptoms, viral load, CD4, alcohol and illicit drug use, depression, and social support. Multinomial logistic regression analyses modeled the independent associations of the cross-sectional set of predictors with smoking status. Results indicated that 74% of the sample smoked at least one cigarette per day; using standard definitions, 23% of the sample were light smokers, 22% were moderate smokers, and 29% smoked heavily. Smoking was associated with more HIV-related symptoms, greater alcohol and marijuana use, and less social support. Light smoking was related to minority race/ethnicity and less income; moderate smoking was associated with less education; and heavy smoking was related to less education and younger age. Viral load, CD4 count, and depression were not associated with smoking status. Psychosocial interventions targeting this population should consider the relationships between biopsychosocial factors and smoking behavior. High Smoking Prevalence among HIV+ Men and Women: Examining Health, Substance Use, and Psychosocial Correlates across the Smoking SpectrumSmoking is highly prevalent among persons living with HIV and may contribute to premature morbidity and mortality. Among HIV+ individuals, prevalence rates of smoking range from 50% to 70% (Burkhalter et al., 2005;Miguez-Burbano et al., 2005;Niaura et al., 2000) compared to 21% for the general population (CDC, 2005). Smoking is strongly associated with two of the primary causes of illness and death in HIV+ patients: community-acquired pneumonia (CAP) and Pneumocystis jiroveci pneumonia (formerly known as Pneumocystis ciroveci; Arcavi & Benowitz, 2004;Miguez-Burbano et al., 2005). HIV+ smokers are also at increased risk for oral lesions (Palacio et al., 1997) Beck & Slade, 1996), and AIDS-related spontaneous pneumothorax (Metersky et al., 1995).Young smokers infected with HIV may be particularly vulnerable to malignant tumors, such as lung cancer (Patel et al., 2006;Spano et al., 2004). Moreover, smoking by HIV+ patients may facilitate the progression to Acquired Immune Deficiency Syndrome (AIDS) (Neiman et al., 1993).Evidence also suggests that smoking has adverse effects on the health-related quality of life (HRQL) of HIV+ men and women. Vidrine et al. (2006) tested a framework for HRQL of life among HIV+ individuals. They found that HRQL is influenced by relationships among physical symptoms, and cognitive, psychological, and social functioning (Brenner et al., 1995;Wilson & Cleary, 1995). They also found that smoking, alcohol use, and SES impair overall HRQL. Other work has also found rel...

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“…Only f e w o f t h e m ( 9 . 1 % ) r e p o r t e d s m o k i n g marijuana/using dronabinol ineffective (Prentiss et al, 2004). Moreover, Haney et al showed also that cannabinoids from marijuana or dronabinol can improve mood without producing disruptions in psychomotor functioning and add benefit of improving rating of sleep (Haney et al, 2007).…”

Section: Mood Controlmentioning

confidence: 99%

Cannabinoids – Influence on the Immune System and Their Potencial Use in Supplementary Therapy of HIV/AIDS

Szulakowska¹,

Milnerowicz²

2011

HIV and AIDS - Updates on Biology, Immunology, Epidemiology and Treatment Strategies

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Patterns of Marijuana Use Among Patients With HIV/AIDS Followed in a Public Health Care Setting

Cited by 128 publications

References 30 publications

Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

Cigarette Smoking among HIV+ Men and Women: Examining Health, Substance Use, and Psychosocial Correlates across the Smoking Spectrum

Cannabinoids – Influence on the Immune System and Their Potencial Use in Supplementary Therapy of HIV/AIDS

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