Patterns Of Metachronous Metastases After Curative Treatment Of Breast Cancer

Abstract

To evaluate reduction whether endoscopic screening reduces mortality from gastric cancer, a population-based cohort study was performed in Japan, where both radiographic screening and endoscopic screening for gastric cancer have been conducted. MethOds: The subjects were selected from among participants in gastric cancer screening in 2 cities (Tottori and Yonago) from 2007 to 2008. The subjects were defined as participants aged 40-79 years with no gastric cancer screening in the previous year. Follow-up related to mortality was continued from the date of the first screening to the date of death or up to December 31, 2013. A Cox proportional hazards model was used to estimate the relative risks (RRs) of incident gastric cancer, gastric cancer death, all cancer deaths except gastric cancer death, and all-cause death except gastric cancer death. Results: The subjects were 9,950 participants in endoscopic screening and 4,324 participants in radiographic screening. The endoscopic screening group showed a 67% reduction from gastric cancer compared to that of radiographic screening group (RR adjusted by sex, age group, and city of residence = 0.327, 95%CI: 0.117-0.905). The adjusted RR of endoscopic screening was 0.966 (95%: 0.674-1.385) for all cancer deaths except gastric cancer death and 0.932 (95%:0.742-1.170) for all-cause deaths except gastric cancer death. cOnclusiOns: The results of the present study suggest that endoscopic screening can decrease mortality from gastric cancer by 67% compared with radiographic screening. The results are consistent with the previous studies that showed that endoscopic screening reduces mortality reduction from gastric cancer.