Patterns of Metastasis and Survival in Breast Cancer Patients: A Preliminary Study in an iranian Population

Ziaei, Jamal Eivazi; Pourzand, Ali; Bayat, Amrollah; Vaez, Jalil

doi:10.7314/apjcp.2012.13.3.937

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…Its mechanism of metastasis suppression studied on three levels including an assessment of its intrinsic biochemical activities, protein -protein interaction, and alteration of downstream gene expression. DNA methylation has been reported to have an impact on breast cancer metastasis (Ziaei et al, 2012). Elevations of Nm23-H1 expression in human breast carcinoma cell line, MDA-MB-231 are associated with demethylation of a specific CpG island.…”

Section: 3539 Targeting Tumor Metastasis By Regulating Nm23 Gene Expmentioning

confidence: 99%

Targeting Tumor Metastasis by Regulating Nm23 Gene Expression

Prabhu

Siddikuzzaman²,

Grace³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The Nm23 gene is a metastatic suppressor identified in a melanoma cell line and expressed in different tumors where their levels of expression are associated with reduced or increased metastatic potential. Nm23 is one of the over 20 metastasis suppressor genes (MSGs) confirmed in vivo. It is highly conserved from yeast to human, implying a critical developmental function. Tumors with alteration of the p53 gene and reduced expression of the Nm23 gene are more prone to metastasis. Nm23-H1 has 3'-5' exonuclease activity. This review focuses on the role of Nm23 in cancer progression and also a potential novel target for cancer therapy.

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Section: 3539 Targeting Tumor Metastasis By Regulating Nm23 Gene Expmentioning

confidence: 99%

Targeting Tumor Metastasis by Regulating Nm23 Gene Expression

Prabhu

Siddikuzzaman²,

Grace³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…It was striking that the number of patients in Luminal A group (n=14) were less than other groups and this finding was consistent with the literature. In addition, there have been many studies showing that ER and/or PR secretion reduces the risk of metastatic disease (Hoefnagel et al, 2010;Karlsson et al, 2010;Gong et al, 2011;Ziaei et al, 2012). Another important factor in the current study was the difference between the molecular sub-types and mean tumour sizes at the patients with BM.…”

Section: Discussionmentioning

confidence: 75%

Lymph Node Ratio Assessment of Brain Metastasis in Early Breast Cancer Cases

Demircioğlu

Demırcı²,

Akmansu³

2013

Asian Pacific Journal of Cancer Prevention

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Background: Ten to 30% of early breast cancer (EBC) patients develop brain metastasis (BM) during their follow-up. In this study, we aimed to evaluate importance of the lymph node ratio (LNR) in development of BM in EBC cases. Materials and Methods: Ninety patients whom had axillary metastases in lymph nodes at their initial diagnosis and developed BM during 5-year follow-up were detected in 950 EBC patients. LNR values were calculated for all patients and after categorization into 4 molecular sub-types as luminal A, luminal B HER-2 (+), HER-2 overexpressing and basal-like. Comparison was with control group patients who had similar characteristics. Results: In the comparison of all molecular sub-types of LNR, 54.9% and 28.4% values were found in patients with and without BM respectively (p<0.001). In the comparison of the LNR with control groups, a statistically significant differences were found with luminal A with BM (p=0.001), luminal B HER-2 (p=0.001), HER-2 overexpressing (p=0.027) and basal-like groups (p<0.001). In the evaluation of patients with BM, the highest ratio was found in the basal-like group (67.9%) and there was a statistically significant difference between this group and the others (p=0.048). Conclusions: EBC patients developing BM within 5 years followup had significantly higher LNRs for all molecular sub-types, especially in the basal-like group. Larger scale studies are now needed for evaluating LNR prognostic importance for EBC regarding BM development.

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“…Kobayashi et al report a case series of 30 year experience with aggressive multidisciplinary treatment of breast cancer with relapse free rate of 42% at 20 years with patients with metastasis to a single organ [9] . Ziaei et al reported that patients with breast cancer skeletal metastasis vs. other site metastasis has a slight survival benefit [10] . Milano et al reported 85 metastatic lesions in 40 breast cancer patients treated with Stereotactic Body Radiation Treatment, achieving a 4-year overall survival of 59%.…”

Section: Discussionmentioning

confidence: 99%