Patterns of multi-domain cognitive aging in participants of the Long Life Family Study

Sebastiani, Paola; Andersen, Stacy L.; Sweigart, Benjamin; Du, Mengtian; Cosentino, Stephanie; Thyagarajan, Bharat; Christensen, Kaare; Schupf, Nicole; Perls, Thomas T.

doi:10.1007/s11357-020-00202-3

Cited by 27 publications

(33 citation statements)

References 51 publications

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“…The strong relationship between higher levels of PA and better cognitive function are well-established, [1][2][3][4][5] and our results confirm this association. To the best of our knowledge, our study was the first to investigate this association using a data-driven approach to identify PA trajectories.…”

Section: Discussionsupporting

confidence: 86%

“…Physical activity (PA) and cognitive performance (CP) are strongly linked and have been shown to decline with ageing. [1][2][3][4][5] Multiple observational and interventional studies have demonstrated that a higher level of PA is associated with better CP in old age. [6][7][8][9][10][11][12][13][14] However, most of these studies focused on the association between PA levels and CP.…”

Section: Introductionmentioning

confidence: 99%

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Association between physical-activity trajectories and cognitive decline in adults 50 years of age or older

Cheval

Csajbók

Formánek

et al. 2021

Preprint

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Objectives: To investigate the associations of physical-activity trajectories with the level of cognitive performance and its decline in adults 50 years of age or older. Methods: We studied 38729 individuals (63 years; 57% women) enrolled in the Survey of Health, Ageing and Retirement in Europe (SHARE). Physical activity was self-reported and cognitive performance was assessed based on immediate recall, verbal fluency, and delayed recall. Physical-activity trajectories were estimated using growth mixture modelling and linear mixed effects models were used to investigate the associations between the trajectories and cognitive performance. Results: The models identified two physical-activity trajectories of physical activity: constantly-high physical activity (N=27634: 71%) and decreasing physical activity (N=11095; 29%). Results showed that participants in the decreasing physical-activity group exhibited a lower level of cognitive performance compared to the high physical-activity group (immediate recall: b=0.94; 95% confidence interval [CI]=0.92 to 0.95; verbal fluency: b=0.98; 95% CI=0.97 to 0.98; delayed recall: b=0.95; 95% CI=0.94 to 0.97). Moreover, compared with participants in the constantly-high physical-activity group, participants in the decreasing physical-activity group showed a steeper decline in all cognitive measures (immediate recall: b=-0.04; 95% CI=-0.05 to -0.04; verbal fluency: b=-0.22; 95% CI=-0.24 to -0.21; delayed recall:b=-0.04; 95% CI=-0.05 to -0.04). Conclusions: Physical-activity trajectories are associated with the level and evolution of cognitive performance in adults over 50 years. Specifically, our findings suggest that a decline in physical activity over multiple years is associated with a lower level and a steeper decline in cognitive performance.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Association between physical-activity trajectories and cognitive decline in adults 50 years of age or older

Cheval

Csajbók

Formánek

et al. 2021

Preprint

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“…Previous studies have found that spatiotemporal parameters such as gait velocity, stride time, and stride length are correlated with cognitive domains of memory, executive function, and attention in the elderly with MCI ( Xie et al, 2019 ). A recent study has shown that faster gait speed was associated with a change in immediate recall but not delayed recall memory ( Sebastiani et al, 2020 ). While another study showed that executive function had a strong correlation with gait speed compared to other cognitive domains in patients with cognitive impairment ( Toots et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Gait Kinematic and Kinetic Characteristics of Older Adults With Mild Cognitive Impairment and Subjective Cognitive Decline: A Cross-Sectional Study

Zhong

Ali

Gao

et al. 2021

Front. Aging Neurosci.

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BackgroundOlder adults with mild cognitive impairment (MCI) have slower gait speed and poor gait performance under dual-task conditions. However, gait kinematic and kinetic characteristics in older adults with MCI or subjective cognitive decline (SCD) remain unknown. This study was designed to explore the difference in gait kinematics and kinetics during level walking among older people with MCI, SCD, and normal cognition (NC).MethodsThis cross-sectional study recruited 181 participants from July to December 2019; only 82 met the inclusion criteria and consented to participate and only 79 completed gait analysis. Kinematic and kinetic data were obtained using three-dimensional motion capture system during level walking, and joint movements of the lower limbs in the sagittal plane were analyzed by Visual 3D software. Differences in gait kinematics and kinetics among the groups were analyzed using multivariate analysis of covariance (MANCOVA) with Bonferroni post-hoc analysis. After adjusting for multiple comparisons, the significance level was p < 0.002 for MANCOVA and p < 0.0008 for post-hoc analysis.ResultsTwenty-two participants were MCI [mean ± standard deviation (SD) age, 71.23 ± 6.65 years], 33 were SCD (age, 72.73 ± 5.25 years), and 24 were NC (age, 71.96 ± 5.30 years). MANCOVA adjusted for age, gender, body mass index (BMI), gait speed, years of education, diabetes mellitus, and Geriatric Depression Scale (GDS) revealed a significant multivariate effect of group in knee peak extension angle (F = 8.77, p < 0.0001) and knee heel strike angle (F = 8.07, p = 0.001) on the right side. Post-hoc comparisons with Bonferroni correction showed a significant increase of 5.91° in knee peak extension angle (p < 0.0001) and a noticeable decrease of 6.21°in knee heel strike angle (p = 0.001) in MCI compared with NC on the right side. However, no significant intergroup difference was found in gait kinetics, including dorsiflexion, plantar flexion, knee flexion, knee extension, hip flexion, and hip extension(p > 0.002).ConclusionAn increase of right knee peak extension angle and a decrease of right knee heel strike angle during level walking were found among older adults with MCI compared to those with NC.

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“…Our findings are consistent with previous studies that showed a decline of cognitive function with older age in multiple domains ( Harada et al, 2013 ), and the negative effect of APOE e4 on cognitive decline in centenarians ( Arosio et al, 2017 ; Du et al, 2020 ). There is some evidence that, among centenarians, the e2 allele confers protection from cognitive decline ( Kim et al, 2017 ; Sebastiani et al, 2020 ), in addition to increasing the chance for longevity ( Sebastiani et al, 2019a ) and conferring protection from aging-related diseases ( Wolters et al, 2019 ; Kuo et al, 2020 ). Our studies also found that carriers of e2 with low education can delay their onset of moderate cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

Studying the Interplay Between Apolipoprotein E and Education on Cognitive Decline in Centenarians Using Bayesian Beta Regression

et al. 2021

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Apolipoprotein E (APOE) is an important risk factor for cognitive decline and Alzheimer’s disease in aging individuals. Among the 3 known alleles of this gene: e2, e3, and e4, the e4 allele is associated with faster cognitive decline and increased risk for Alzheimer’s and dementia, while the e2 allele has a positive effect on longevity, and possibly on preservation of cognitive function. Education also has an important effect on cognition and longevity but the interplay between APOE and education is not well-characterized. Previous studies of the effect of APOE on cognitive decline often used linear regression with the normality assumption, which may not be appropriate for analyzing bounded and skewed neuropsychological test scores. In this paper, we applied Bayesian beta regression to assess the effect of APOE alleles on cognitive decline in a cohort of centenarians with longitudinal assessment of their cognitive function. The analysis confirmed the negative association between older age and cognition and the beneficial effect of education that persists even at the extreme of human lifespan in carriers of the e3 allele. In addition, the analysis showed an association between APOE and cognition that is modified by education. Surprisingly, an antagonistic interaction existed between higher education and APOE alleles, suggesting that education may reduce the positive effect of APOE e2 and increase the negative effect of APOE e4 at extreme old age.

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Patterns of multi-domain cognitive aging in participants of the Long Life Family Study

Cited by 27 publications

References 51 publications

Association between physical-activity trajectories and cognitive decline in adults 50 years of age or older

Association between physical-activity trajectories and cognitive decline in adults 50 years of age or older

Gait Kinematic and Kinetic Characteristics of Older Adults With Mild Cognitive Impairment and Subjective Cognitive Decline: A Cross-Sectional Study

Studying the Interplay Between Apolipoprotein E and Education on Cognitive Decline in Centenarians Using Bayesian Beta Regression

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