Patterns of multimorbidity and some psychiatric disorders: A systematic review of the literature

Abstract

Objective: The presence of two or more chronic diseases results in worse clinical outcomes than expected by a simple combination of diseases. This synergistic e ect is expected to be higher when combined with some conditions, depending on the number and severity of diseases. Multimorbidity is a relatively new term, with the first fundamental definitions appearing in . Studies usually define it as the presence of at least two chronic medical illnesses. However, little is known regarding the relationship between mental disorders and other non-psychiatric chronic diseases. This review aims at investigating the association between some mental disorders and non-psychiatric diseases, and their pattern of association.Methods: We performed a systematic approach to selecting papers that studied relationships between chronic conditions that included one mental disorder from to . These were processed using Covidence, including quality assessment.Results: This resulted in the inclusion of papers in this study. It was found that there are strong associations between depression, psychosis, and multimorbidity, but recent studies that evaluated patterns of association of diseases (usually using clustering methods) had heterogeneous results. Quality assessment of the papers generally revealed low quality among the included studies.Conclusions: There is evidence of an association between depressive disorders, anxiety disorders, and psychosis with multimorbidity. Studies that tried to examine the patterns of association between diseases did not find stable results.Systematic review registration: https://www.crd.york.ac.uk/prospero/display _record.php?ID=CRD , identifier: CRD .

Chronic Disease Patterns and Their Relationship With Health-Related Quality of Life in South Korean Older Adults With the 2021 Korean National Health and Nutrition Examination Survey: Latent Class Analysis

“…Multimorbidity is indicated by the presence of 2 or more of the diseases in a single individual. The diagnosis of chronic conditions was based on whether the respondent had ever been diagnosed with a chronic disease by a doctor and received treatment for that disease [ 3 , 7 , 8 ]. When the prevalence of multimorbidity is low, the sample size for certain combinations of multimorbid conditions may be insufficient to provide reliable results [ 9 ].…”

“…Health-related quality of life (HRQoL) is an important health outcome indicator in the aging process. Previous observational studies have shown the negative effects of multimorbidity on HRQoL [ 7 , 8 ].…”

“…However, few studies have applied LCA to extract the multimorbidity patterns among Korean older adults. Understanding which chronic conditions frequently co-occur can facilitate person-centered care tailored to the needs of individuals with specific profiles of multimorbidity [ 7 , 8 , 11 , 12 ]. One of the first steps is to identify the prevalence and distinct patterns of multimorbidity to inform clinical guidelines and facilitate integrated care [ 9 , 10 ].…”

Evidence of depression affecting multimorbidity in survey data from the Brazilian population

“…There is evidence that depression is associated with multimorbidity, the occurrence of two or more chronic diseases. It has been shown that the direction of this association seems to run from multimorbidity to depression 4,5 . As individuals age, they tend to become alone, losing friends and family members, which renders them susceptible to depressive symptoms 6 .…”

“…There is an ongoing effort of trying to identify patterns of clustering for these conditions, which varies significantly across studies 12 . A three-cluster pattern seems to be emerging, with musculoskeletal, cardiometabolic, and neuropsychiatric clusters 4,12 . Furthermore, being overweight is associated with multimorbidity in a dose-response pattern.…”