Patterns of onset and outcome of cryptogenic organizing pneumonia after allogeneic hematopoietic stem cell transplantation

Adachi, Yoshitaka; Ozeki, Kazutaka; Ukai, Shun; Sagou, Ken; Fukushima, Norishige; Kohno, Akio

doi:10.1007/s12185-019-02643-9

Cited by 8 publications

(3 citation statements)

References 30 publications

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“…Therefore, smoking would induce chronic pulmonary inflammation. In allo-HCT recipients, the conditioning toxicity and allo-immune response may further increase the infiltration of lymphocytes or macrophages [26][27][28][29], which eventually might result in the development of BO or IP, although the true reasons remain to be elucidated. Smoking is also associated with coronary disease and stroke [30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Effect of Smoking on Outcomes of Allogeneic Transplantation: A Single-Center Analysis

Tamaki

Nakasone

Kawamura

et al. 2020

Biology of Blood and Marrow Transplantation

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Pulmonary complications are fatal adverse events after allogeneic hematopoietic cell transplantation (allo-HCT). On the other hand, smoking is a well-known risk factor for various pulmonary diseases and also increases the incidence of pulmonary complications and overall mortality in allo-HCT recipients. In this study, we retrospectively assessed the impact of smoking intensity on survival outcomes. This study included consecutive allo-HCT recipients at our center between June 2007 and May 2019 whose smoking profiles were available (n = 408); they were divided into high (pack-years >10, n = 171) and low (pack-years 10, n = 231) pack-years groups. In univariate analyses, nonrelapse mortality (NRM) and overall survival (OS) were significantly inferior in the high pack-years group (1-year NRM 26.6% versus 13.9%, P < .001; 1-year OS 58.4% versus 70.1%, P = .0067). However, this association was not observed in multivariate analyses. In subgroup analyses according to sex, the survival outcomes in the high pack-years group were significantly inferior in males (NRM hazard ratio [HR], 2.24 [95% confidence interval (CI), 1.23 to 4.

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Section: Discussionmentioning

confidence: 99%

Effect of Smoking on Outcomes of Allogeneic Transplantation: A Single-Center Analysis

Tamaki

Nakasone

Kawamura

et al. 2020

Biology of Blood and Marrow Transplantation

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“…Organizing pneumonia (OP) has an incidence of approximately 10% after HSCT [ 54 ]. It occurs in both autologous and allogeneic HSCT, but it is more common in allogeneic recipients and can occur as a manifestation of cGVHD [ 55 , 56 ].…”

Section: Late Post-transplantation Period (>100 Days Post-transplant)mentioning

confidence: 99%

Pulmonary Complications in Hematopoietic Stem Cell Transplant Recipients—A Clinician Primer

Astashchanka

Ryan

Lin

et al. 2021

JCM

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Hematopoietic stem cell transplants (HSCT) are becoming more widespread as a result of optimization of conditioning regimens and prevention of short-term complications with prophylactic antibiotics and antifungals. However, pulmonary complications post-HSCT remain a leading cause of morbidity and mortality and are a challenge to clinicians in both diagnosis and treatment. This comprehensive review provides a primer for non-pulmonary healthcare providers, synthesizing the current evidence behind common infectious and non-infectious post-transplant pulmonary complications based on time (peri-engraftment, early post-transplantation, and late post-transplantation). Utilizing the combination of timing of presentation, clinical symptoms, histopathology, and radiographic findings should increase rates of early diagnosis, treatment, and prognostication of these severe illness states.

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“…Non-infectious pulmonary complications include various disease entities, leading to fatal diseases after allogeneic hematopoietic cell transplantation (allo-HCT) [ 1 – 6 ]. However, a distinct definition of these complications has not been clearly described, since the diagnosis of non-infectious pulmonary complications is mainly based on the exclusion of other diseases [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Interstitial lung disease with anti-melanoma differentiation-associated gene 5 antibody after allogeneic hematopoietic stem cell transplantation

Tamaki

Matsumi

Nakasone

et al. 2022

Bone Marrow Transplant

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Anti-melanoma differentiation-associated gene 5 (MDA5) antibody is one of auto-immune antibodies which is associated with a rare subtype of dermatomyositis (DM), and MDA5-DM is well-characterized by rapid progressive interstitial lung disease (ILD) which in part resembles pulmonary complications after allogeneic hematopoietic cell transplantation (allo-HCT). However, previous studies about anti-MDA5 antibody after allo-HCT were extremely limited. Here, we present 4 cases of ILD with anti-MDA5 antibody after allo-HCT. All of the cases showed rapidly progressive clinical course and 3 of 4 cases died despite intensive immunosuppressive therapies which included prednisolone, cyclophosphamide and calcineurin inhibitor. Additionally, 3 of 4 cases had tested positive for anti-MDA5 antibody by using cryopreserved plasma which were collected about 2–3 months before the diagnosis of MDA5-DM-ILD. It suggests that an inflammatory condition due to MDA5-DM-ILD might have sub-clinically occurred before the development of respiratory failure. The current cases suggest that the clinical feature was relatively similar to classical MDA5-DM-ILD, although it is difficult to distinguish MDA5-DM-ILD from chronic GVHD and other pulmonary complications after allo-HCT. Since clinical courses of MDA5-DM-ILD is considerably aggressive, it is important to discriminate MDA5-DM-ILD from other complications after allo-HCT.

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Patterns of onset and outcome of cryptogenic organizing pneumonia after allogeneic hematopoietic stem cell transplantation

Cited by 8 publications

References 30 publications

Effect of Smoking on Outcomes of Allogeneic Transplantation: A Single-Center Analysis

Effect of Smoking on Outcomes of Allogeneic Transplantation: A Single-Center Analysis

Pulmonary Complications in Hematopoietic Stem Cell Transplant Recipients—A Clinician Primer

Interstitial lung disease with anti-melanoma differentiation-associated gene 5 antibody after allogeneic hematopoietic stem cell transplantation

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