Patterns of ovarian morphology in polycystic ovary syndrome: a study utilising magnetic resonance imaging

Barber, Thomas M.; Alvey, Christopher; Greenslade, Tessa; Gooding, Mark J.; Barber, Debbie; Smith, Robert F.; Marland, Anne; Wass, John; Child, Tim; McCarthy, Mark I.; Golding, Stephen J.

doi:10.1007/s00330-009-1643-8

Cited by 36 publications

(23 citation statements)

References 18 publications

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“…In contrast, healthy adult women exhibit only a 15–25% prevalence of PCOM. We observed a 12.8 and 23.5% prevalence of PCOM in healthy adolescents when the PedC and AES/PCOS criteria were used, respectively, which is similar to or even lower than the prevalence reported in adults [6, 20-23]. …”

Section: Discussionsupporting

confidence: 69%

New Diagnostic Criteria of Polycystic Ovarian Morphology for Adolescents: Impact on Prevalence and Hormonal Profile

et al. 2017

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Background: The ultrasonographic criteria used to identify polycystic ovarian morphology (PCOM) during adolescence have changed over time. Recently, a Worldwide Pediatric Consensus (PedC) defined PCOM using stricter criteria than the previous recommendations of the Rotterdam Consensus (RC) and Androgen Excess-Polycystic Ovarian Syndrome Society (AES/PCOS) criteria. The aim of this study was to determine the prevalence of PCOM in healthy adolescents according to the 3 reported diagnostic criteria and compare the hormonal profile in females with and without PCOM based on the PedC criteria. Methods: Nonobese adolescents (n = 102) with regular menstrual cycles were studied. Transabdominal ultrasound and hormonal profiles were assessed during the follicular phase. PCOM was defined on the basis of the 3 published criteria. Results: On the basis of the PedC, RC, and AES/PCOS criteria, PCOM was diagnosed in 13, 34, and 24% of adolescents, respectively. Adolescents with and without PCOM according to the PedC criteria had similar androgen levels. Serum anti-Müllerian hormone (AMH) levels were elevated in adolescents with PCOM, irrespective of the criteria used. Conclusions: Use of the new PedC diagnostic criteria for PCOM results in a lower prevalence of this ultrasonographic pattern in adolescents, but this condition is not associated with hyperandrogenism. Elevated AMH is associated with PCOM in adolescents regardless of the criteria used to determine the ultrasonographic pattern.

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Section: Discussionsupporting

confidence: 69%

New Diagnostic Criteria of Polycystic Ovarian Morphology for Adolescents: Impact on Prevalence and Hormonal Profile

et al. 2017

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“…The cut-off levels associated with PCOS in adolescents for OV and FN were 10 ml and 12 follicles, respectively, similar to those reported for adult women. This was an unexpected result, as higher OV and FN values have been reported for adolescents compared with adult women [24,25].…”

Section: Discussionmentioning

confidence: 65%

Hirsutism and oligomenorrhea are appropriate screening criteria for polycystic ovary syndrome in adolescents

Villarroel

López

Merino

et al. 2015

Gynecological Endocrinology

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We evaluated the association of hirsutism and oligomenorrhea (persistent menstrual cycles > 45 days) as screening criteria for the detection of biochemical hyperandrogenism (BH) and polycystic ovaries (PCOM) during adolescence and determined which androgens, granulosa cell hormone, ultrasonographic parameters have the best association with polycystic ovary syndrome (PCOS). Hirsute girls with oligomenorrhea (N = 26 Hirs/Oligo group) and non-hirsute girls with regular cycles (N = 63, C group) were studied. Prevalence of BH and PCOM, diagnostic performance of androgens and ultrasound parameters for PCOS diagnosis were analyzed. BH and PCOM prevalence were higher in the Hirs/Oligo girls than in the C girls (76.9% versus 25.5%; 92.3% versus 33.3%, respectively; p < 0.0001). A complete PCOS phenotype (Hirs/Oligo with BH and PCOM) was observed in 73.1% of the Hirs/Oligo group. The presence of both BH and PCOM was observed in 7.9% of the C group. The parameters with the best diagnostic performance were free androgen index ≥6.1, testosterone ≥2.4 nmol/L, follicle number ≥12 and ovarian volume ≥10 ml anti-Müllerian hormone (AMH) exhibited a low diagnostic accuracy. Hirsutism and persistent menstrual cycle over 45 days are highly associated with BH and PCOM suggesting that the presences of both criteria are necessary for the diagnosis of PCOS during adolescence.

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“…MRI evaluation of polycystic ovarian morphology in adult women has been reported previously (). Similar to findings on ultrasound, MRI findings overlap between subjects with and without clinical and biochemical evidence of PCOS.…”

Section: Discussionmentioning

confidence: 99%

Ovarian imaging by magnetic resonance in adolescent girls with polycystic ovary syndrome and age‐matched controls

Brown

Park

Shayya

et al. 2013

Magnetic Resonance Imaging

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Purpose To compare ovarian morphology in adolescent girls with and without polycystic ovary syndrome (PCOS) using magnetic resonance (MR) imaging. Materials and Methods In 21 adolescent girls (12–18 years) without and 19 adolescents with PCOS (diagnosis based on excessive hair growth and irregular menstrual cycles) ovarian volume, antral follicle count (AFC) per ovary, and follicle size were evaluated. MR imaging was performed at 1.5 T or 3 T and axial or angled-axial single-shot echo-train spin echo images of 6 mm slice thickness were acquired. In a subset of subjects, 2 mm images were also obtained. PCOS and non-PCOS groups were compared using mixed affects regression. Results Mean AFC per ovary and ovarian volume were substantially greater in PCOS subjects compared to non-PCOS subjects. Mean follicle size was similar between groups. Follicles exceeding 10 mm were seen in 2/19 PCOS subjects versus 9/21 non-PCOS subjects. Consistently higher follicle counts were detected in images obtained at 2 mm compared to 6 mm slice thickness. Conclusion In adolescence MR imaging of the ovary reveals distinct differences between girls with and without PCOS. MR imaging may help evaluate young patients in whom transvaginal ultrasound is contraindicated.

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Patterns of ovarian morphology in polycystic ovary syndrome: a study utilising magnetic resonance imaging

Abstract: Ovarian morphology overlaps in PCOS cases and controls, emphasising the importance of considering clinical/biochemical presentation together with imaging ovarian morphology in the diagnosis of PCOS.

Cited by 36 publications

References 18 publications

New Diagnostic Criteria of Polycystic Ovarian Morphology for Adolescents: Impact on Prevalence and Hormonal Profile

New Diagnostic Criteria of Polycystic Ovarian Morphology for Adolescents: Impact on Prevalence and Hormonal Profile

Hirsutism and oligomenorrhea are appropriate screening criteria for polycystic ovary syndrome in adolescents

Ovarian imaging by magnetic resonance in adolescent girls with polycystic ovary syndrome and age‐matched controls

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