Patterns of postictal cerebral perfusion in idiopathic generalized epilepsy: a multi-delay multi-parametric arterial spin labelling perfusion MRI study

Chen, Guangxiang; Lei, Du; Ren, Jiechuan; Zuo, Panli; Suo, Xueling; Wang, Danny J.J.; Wang, Meiyun; Zhou, Dong; Gong, Qiyong

doi:10.1038/srep28867

Cited by 19 publications

(21 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SPM has proved to be an objective and useful method for quantitative analysis in epilepsy with FDG-PET and ASL MR imaging. 28,40 Metabolic abnormalities were mainly found in the middle temporal gyrus when comparing patients with healthy controls. However, no statistically significant hypoperfusion was observed in the qualitative assessment of CBF maps, potentially due to the limiting size of the patient cohort.…”

Section: Discussionmentioning

confidence: 99%

Clinical Value of Hybrid TOF-PET/MR Imaging–Based Multiparametric Imaging in Localizing Seizure Focus in Patients with MRI-Negative Temporal Lobe Epilepsy

Shang¹,

Wang²,

Fan³

et al. 2018

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE: Temporal lobe epilepsy is the most common type of epilepsy. Early surgical treatment is superior to prolonged medical therapy in refractory temporal lobe epilepsy. Successful surgical operations depend on the correct localization of the epileptogenic zone. This study aimed to evaluate the clinical value of hybrid TOF-PET/MR imaging-based multiparametric imaging in localizing the epileptogenic zone in patients with MR imaging-negative for temporal lobe epilepsy. MATERIALS AND METHODS: Twenty patients with MR imaging-negative temporal lobe epilepsy who underwent preoperative evaluation and 10 healthy controls were scanned using PET/MR imaging with simultaneous acquisition of PET and arterial spin-labeling. On the basis of the standardized uptake value and cerebral blood flow, receiver operating characteristic analysis and a logistic regression model were used to evaluate the predictive value for the localization. Statistical analyses were performed using statistical parametric mapping. The values of the standardized uptake value and cerebral blood flow, as well as the asymmetries of metabolism and perfusion, were compared between the 2 groups. Histopathologic findings were used as the criterion standard. RESULTS: Complete concordance was noted in lateralization and localization among the PET, arterial spin-labeling, and histopathologic findings in 12/20 patients based on visual assessment. Concordance with histopathologic findings was also obtained for the remaining 8 patients based on the complementary PET and arterial spin-labeling information. Receiver operating characteristic analysis showed that the sensitivity and specificity of PET, arterial spin-labeling, and combined PET and arterial spin-labeling were 100% and 81.8%, 83.3% and 54.5%, and 100% and 90.9%, respectively. When we compared the metabolic abnormalities in patients with those in healthy controls, hypometabolism was detected in the middle temporal gyrus (P Ͻ .001). Metabolism and perfusion asymmetries were also located in the temporal lobe (P Ͻ .001). CONCLUSIONS: PET/MR imaging-based multiparametric imaging involving arterial spin-labeling may increase the clinical value of localizing the epileptogenic zone by providing concordant and complementary information in patients with MR imaging-negative temporal lobe epilepsy. ABBREVIATIONS: AI ϭ asymmetry index; ASL ϭ arterial spin-labeling; EZ ϭ epileptogenic zone; FCD ϭ focal cortical dysplasia; HS ϭ hippocampal sclerosis; SPM ϭ statistical parametric mapping; SUV ϭ standardized uptake value; SUVr ϭ standardized uptake value ratio; TLE ϭ temporal lobe epilepsy

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Value of Hybrid TOF-PET/MR Imaging–Based Multiparametric Imaging in Localizing Seizure Focus in Patients with MRI-Negative Temporal Lobe Epilepsy

Shang¹,

Wang²,

Fan³

et al. 2018

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…68 Arterial spin labeling (ASL) MRI seems to be a promising technique in the identification of epileptic foci. 94,95 Seizures and thrombolysis…”

Section: Not Reported -mentioning

confidence: 99%

“…Aphasic SE is also associated with temporoparietal DWI hyperintensity with corresponding hyperperfusion 68 . Arterial spin labeling (ASL) MRI seems to be a promising technique in the identification of epileptic foci 94 , 95 …”

Section: Ess After Strokementioning

confidence: 99%

Early seizures after ischemic stroke: focus on thrombolysis

et al. 2019

View full text Add to dashboard Cite

Introduction.Stroke is a significant underlying cause of epilepsy. Seizures due to ischemic stroke (IS) are generally categorized into early seizures (ESs) and late seizures (LSs). Seizures in thrombolysis situations may raise the possibility of other etiology than IS.Aim.We overtook a systematic review focusing on the pathogenesis, prevalence, risk factors, detection, management, and clinical outcome of ESs in IS and in stroke/thrombolysis situations. We also collected articles focusing on the association of recombinant tissue-type plasminogen activator (rt-PA) treatment and epileptic seizures.Results.We have identified 37 studies with 36,775 participants. ES rate was 3.8% overall in patients with IS with geographical differences. Cortical involvement, severe stroke, hemorrhagic transformation, age (<65 years), large lesion, and atrial fibrillation were the most important risk factors. Sixty-one percent of ESs were partial and 39% were general. Status epilepticus (SE) occurred in 16.3%. 73.6% had an onset within 24 h and 40% may present at the onset of stroke syndrome. Based on EEG findings seizure-like activity could be detected only in approximately 18% of ES patients. MRI diffusion-weighted imaging and multimodal brain imaging may help in the differentiation of ischemia vs. seizure. There are no specific recommendations with regard to the treatment of ES.Conclusion.ESs are rare complications of acute stroke with substantial burden. A significant proportion can be presented at the onset of stroke requiring an extensive diagnostic workup.

show abstract

“…This is obvious in the western world where access to advanced tools is feasible. [26,27] Kalnin, et al [15] who used 0.5-1.5T MR in their study recorded a lower proportion of positive MR findings of 31%, with no evidence of cortical defects, while Berg, et al [28] found only 12.7% positive findings on MR. The reason for this low proportion might be because the patients presented after their first seizures.…”

Section: Annals Of Health Research Volume 6 Issue No 4 2020_______mentioning

confidence: 90%

Low-Field Magnetic Resonance Imaging Findings in Children with Seizures in Ibadan, Nigeria

Akinmoladun¹,

Ogbole

Famosaya

et al. 2020

Ann Health Res

View full text Add to dashboard Cite

Background: Seizure is the most common neurological disorder in children and an important cause of paediatric hospital admission with the highest prevalence in the under-five age group. Magnetic Resonance Imaging (MRI) is the neuro-imaging technique of choice in the initial evaluation of children with epilepsy. High-field MRI is the ideal imaging modality for evaluating seizures but this is not readily available in developing countries. Objective: To analyse the spectrum of MRI findings in children presenting with seizures using a low-field (0.36T) MRI. Methods: Children aged ≤18years with seizures, with cranial MRI at the University College Hospital (UCH), Nigeria between January 2013 and June 2015 were retrospectively reviewed. Results: There were a total of 134 patients with 53% as adolescents and most of them (85; 63.4%) had abnormal cranial MRI findings. More male children had abnormal findings (52; 61.2%) and most abnormal findings (42; 49.4%) were reported among adolescents. The most frequent abnormality was hydrocephalus (23.5%) from various causes followed by cerebral tumours (14.1%) and ischaemic cerebral infarcts (11.8%). In the adolescents, intracranial tumours (21.4%) were the most frequent abnormal findings, while hydrocephalus was commoner in children aged less than 10 years, accounting for 33.3% and 36.0% among the 1-5 years and 6-11 years age groups respectively. Conclusion: Low-field MRI, which is more readily available, can provide substantial preliminary findings to aid the management of children with epilepsies. Improved access to high-field MRI through cost reduction and early MR imaging evaluation in the course of illness are desirable.

show abstract

Patterns of postictal cerebral perfusion in idiopathic generalized epilepsy: a multi-delay multi-parametric arterial spin labelling perfusion MRI study

Cited by 19 publications

References 48 publications

Clinical Value of Hybrid TOF-PET/MR Imaging–Based Multiparametric Imaging in Localizing Seizure Focus in Patients with MRI-Negative Temporal Lobe Epilepsy

Clinical Value of Hybrid TOF-PET/MR Imaging–Based Multiparametric Imaging in Localizing Seizure Focus in Patients with MRI-Negative Temporal Lobe Epilepsy

Early seizures after ischemic stroke: focus on thrombolysis

Low-Field Magnetic Resonance Imaging Findings in Children with Seizures in Ibadan, Nigeria

Contact Info

Product

Resources

About