Patterns of pregnancy exposure to prescription FDA C, D and X drugs in a Canadian population

Wen, Shi Wu; Yang, Tubao; Krewski, Daniel; Yang, Qian; Nimrod, Carl; Garner, Peter R.; Fraser, WD; Olatunbosun, Olufemi A.; Walker, Mark

doi:10.1038/jp.2008.6

Cited by 31 publications

(31 citation statements)

References 27 publications

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“…The majority of analgesic drugs were prescription drugs. This agrees with study done in France[10] and Canada[12] which exhibited that NSAIDs belong to the most common prescription drugs in pregnancy.…”

Section: Discussionsupporting

confidence: 93%

Pregnant women and non-steroidal anti-inflammatory drugs: Knowledge, perception and drug consumption pattern during pregnancy in Ethiopia

Kassaw

Wabe

2012

North Am J Med Sci

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Background:Non-steroidal anti-inflammatory drugs (NSAIDs) are among the widely used drugs and are often used by pregnant women. However, they can have significant teratogenic effects. The aim of the study was to investigate pregnant women's knowledge about NSAIDs use during pregnancy and their perception and consumption pattern.Materials and Methods:The study was a cross sectional study on women waiting for a consultation in the selected maternity hospitals in Addis Ababa, Ethiopia. The pregnant women were selected randomly and then interviewed by using standardized questionnaires.Result:A total of 224 pregnant women were involved in the study. Out of those, 203 (90.6%) of them have taken NSAIDs since the beginning of their pregnancy. About 201 (89.7%), 198 (88.4%) and 189 (84.4%) of the pregnant women considered that ibuprofen, diclofenac and aspirin are not NSAIDs respectively. Regarding analgesic effect of NSAIDs, 97 (43.3%) of the pregnant women believed that NSAIDs are effective for treating pain. Acetaminophen was considered as the most effective treatment for pain by 84 (37.50%) of the patients.Conclusion:Acetaminophen is the most common analgesic that was taken by most pregnant women. The knowledge of pregnant women about NSAIDs is poor.

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Section: Discussionsupporting

confidence: 93%

Pregnant women and non-steroidal anti-inflammatory drugs: Knowledge, perception and drug consumption pattern during pregnancy in Ethiopia

Kassaw

Wabe

2012

North Am J Med Sci

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“…Also Wen, Yang, & Krewski, et al . [36] submitted that ginger is a common supplement used for treatment of morning sickness, but there are reports that usage may lead to abortion, mutation of the fetus or increased risk for bleeding. For example, Fischer-Rasmussen, Kjaer, Dahl, et al [37] submitted that ginger has been associated with mutagenesis in a culture of Escherichia coli (E.coli).…”

Section: Discussionmentioning

confidence: 99%

Women’s perception of safety and utilization of herbal remedies during pregnancy in a local government area in Nigeria

Olowokere

A.O.²

2013

Clinical Nursing Studies

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This descriptive study examined the perception of safety and utilization of herbal remedies during pregnancy using a convenience sampling of 300 women. The women who participated in the study were selected at household level from rural communities in Ife-North local government area of Osun state in Nigeria. Data was collected with the aid of semi-structured questionnaire using interviewer-administered method after informed consent had been taken from each participant. The results show that the women had positive perception about the safety and efficacy of herbs over conventional drugs in pregnancy. Greater percentage of the participants studied had used herbs at one point or the other during pregnancy. Local concoction also referred to as "Agbo" was the most used herbs by the women. The need for laboratory exploration of these herbs was emphasized by this study because of the high usage by pregnant women without any empirical evidence on its safety and efficacy.

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“…[4][5][6] Previous study in the USA, Canada and Ireland showed that 4.2-7.8% of pregnant women received potentially teratogenic drugs. 1,[7][8][9][10][11] In the Netherlands, in the period between 1994 and 2003, 1.1% of all drugs received during pregnancy were potentially harmful for the embryo/fetus. 12 In view of the possible impact on public health, it is important to further explore the use of potentially teratogenic drugs among pregnant women in the Netherlands.…”

Section: Introductionmentioning

confidence: 99%

Dispensing of potentially teratogenic drugs before conception and during pregnancy: a population‐based study

Zomerdijk

Ruiter

Houweling

et al. 2014

BJOG

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Objective To study the dispensing of potentially teratogenic drugs in the 12-month period before as well as during pregnancy in the Netherlands.Design Population-based study.Setting A cohort was constructed using a linkage between the PHARMO Database Network and the Netherlands Perinatal Registry (PRN). Mean outcome measures Proportion of pregnancies that received potentially teratogenic drugs in the 12-month period before and during pregnancy and specific for the risk category X drugs and newly initiated drugs.Results Sixteen percent of the pregnancies received a potentially teratogenic drug in the 12-month period before and 5.07% during pregnancy. Doxycycline and paroxetine were most frequently received during pregnancy by 1.01% and 0.85% of women, respectively; 0.66% of the women received a risk category X drug during pregnancy which most frequently consisted of triptorelin (0.25%), norethisterone (0.22%) and simvastatin (0.03%). Fifty-three percent of the women who received a potentially teratogenic drug during pregnancy received this for the first time during the study period. These percentages were heterogeneous between therapeutic drug classes.Conclusions Five percent of the pregnancies received a potentially teratogenic drug during pregnancy and 0.66% received a drug from the risk category X. It may be possible to reduce these proportions when reasons for prescription have been explored.

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Patterns of pregnancy exposure to prescription FDA C, D and X drugs in a Canadian population

Cited by 31 publications

References 27 publications

Pregnant women and non-steroidal anti-inflammatory drugs: Knowledge, perception and drug consumption pattern during pregnancy in Ethiopia

Pregnant women and non-steroidal anti-inflammatory drugs: Knowledge, perception and drug consumption pattern during pregnancy in Ethiopia

Women’s perception of safety and utilization of herbal remedies during pregnancy in a local government area in Nigeria

Dispensing of potentially teratogenic drugs before conception and during pregnancy: a population‐based study

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