Patterns of prescription and adherence to European Association of Urology guidelines on androgen deprivation therapy in prostate cancer: an Italian multicentre cross‐sectional analysis from the Choosing Treatment for Prostate Cancer (CHOICE) study

Morgia, Giuseppe; Russo, Giorgio Ivan; Tubaro, Andrea; Bortolus, Roberto; Randone, D. F.; Gabriele, P.; Trippa, Fabio; Zattoni, Filiberto; Porena, Massimo; Mirone, Vincenzo; Serni, Sergio; Nero, A. Del; Lay, Giancarlo; Ricardi, Umberto; Rocco, Francesco; Terrone, Carlo; Pagliarulo, Arcangelo; Ludovico, Giuseppe Mario; Vespasiani, Giuseppe; Brausi, Maurizio; Simeone, Claudio; Novella, Giovanni; Carmignani, G.; Leonardi, Rosario; Pinnarò, Paola; Paula, Ugo De; Corvò, Renzo; Tenaglia, R.; Siracusano, Salvatore; Mantini, Giovanna; Savoca, G.; Ficarra, Vincenzo

doi:10.1111/bju.13307

Cited by 27 publications

(31 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Adherence to national and international guidelines is suboptimal throughout Europe [17,18,19]. This is particularly true when considering urological diseases.…”

Section: Variation In Practice and Consequences Of Non-adherence To Cpgmentioning

confidence: 99%

“…For example, when considering adherence to the European Association of Urology (EAU) guidelines on the prescription and use of androgen deprivation therapy (ADT) in Italian men with prostate cancer, approximately 1 out of 4 patients received ADT when this was not recommended by evidence-based guidelines [18]. This, in turn, increased the risk of short- and long-term side effects, and the costs related to disease management.…”

Section: Variation In Practice and Consequences Of Non-adherence To Cpgmentioning

confidence: 99%

“…This, in turn, increased the risk of short- and long-term side effects, and the costs related to disease management. In fact, the costs related to the inappropriate management of localised prostate cancer in relation to radiological imaging alone is reported to be in excess of EUR 5 million per year in Italy alone [18]. …”

Section: Variation In Practice and Consequences Of Non-adherence To Cpgmentioning

confidence: 99%

“…Ultimately, the lack of widespread adoption of guidelines has detrimental effects on patient outcomes and increases costs for healthcare systems [17,18,19,29,30]. …”

Section: Variation In Practice and Consequences Of Non-adherence To Cpgmentioning

confidence: 99%

See 3 more Smart Citations

Ensuring Consistent European-Wide Urological Care by the Use of Evidence-Based Clinical Practice Guidelines: Can We Do Better

Smith

MacLennan²,

Bjartell

et al. 2017

Biomed Hub

View full text Add to dashboard Cite

The European Association of Urology (EAU) annually updates 21 clinical practice guidelines in which summaries of the evidence base and best practice recommendations are made. The methodology applied to achieve this and integrate stakeholder opinion is continuously improving. However, there is evidence to suggest wide variation in clinical practice indicating that many patients receive suboptimal and heterogeneous care. Studies from certain countries suggest that 2 out of 5 patients do not receive care according to the current scientific evidence, and in 1 out of 4 cases the care provided is potentially harmful. Clearly, the harmonisation of care in alignment with evidence-based best practice recommendations is something to strive for. Development of robust methods to disseminate and implement guideline recommendations and measure their impact is an objective the EAU is committed to improving. An important strategy for achieving harmonisation in urological care across Europe is to ensure the availability of high-quality clinical practice guidelines and to actively promote their implementation by clinicians and healthcare providers.

show abstract

“…Adherence to national and international guidelines is suboptimal throughout Europe [17,18,19]. This is particularly true when considering urological diseases.…”

Section: Variation In Practice and Consequences Of Non-adherence To Cpgmentioning

confidence: 99%

Section: Variation In Practice and Consequences Of Non-adherence To Cpgmentioning

confidence: 99%

Section: Variation In Practice and Consequences Of Non-adherence To Cpgmentioning

confidence: 99%

“…Ultimately, the lack of widespread adoption of guidelines has detrimental effects on patient outcomes and increases costs for healthcare systems [17,18,19,29,30]. …”

Section: Variation In Practice and Consequences Of Non-adherence To Cpgmentioning

confidence: 99%

See 2 more Smart Citations

Ensuring Consistent European-Wide Urological Care by the Use of Evidence-Based Clinical Practice Guidelines: Can We Do Better

Smith

MacLennan²,

Bjartell

et al. 2017

Biomed Hub

View full text Add to dashboard Cite

show abstract

“…Aunque las GPC utilizadas no son de obligado cumplimiento, están avaladas por una prestigiosa sociedad médica. Estos resultados concuerdan con los de otros estudios similares 4,5 . Por tanto el alto porcentaje de falta de seguimiento de las mismas debe invitar a una reflexión sobre el grado de cumplimiento de las recomendaciones basadas en la evidencia y también sobre el éxito conseguido en la difusión y aplicación de las diferentes GPC.…”

unclassified

Tratamiento del cáncer de próstata en función de la esperanza de vida, la comorbilidad y las guías de práctica clínica

Pérez-Gracia

Ruiz

Fusco

et al. 2015

Anales Sis San Navarra

View full text Add to dashboard Cite

Influences on androgen deprivation therapy prescribing before surgery in high‐risk prostate cancer

Dunsmore,

Duncan,

MacLennan

et al. 2024

BJUI Compass

View full text Add to dashboard Cite

ObjectivesTo understand how best to further reduce the inappropriate use of pre‐surgical androgen deprivation therapy (ADT), we investigated the determinants (influences) of ADT prescribing in urologists in two European countries using an established behavioural science approach. Additionally, we sought to understand how resource limitations caused by COVID‐19 influenced this practice. Identification of key determinants, of undistributed and disrupted practice, will aid development of future strategies to reduce inappropriate ADT prescribing in current and future resource‐limited settings.Participants and MethodsWe conducted semi‐structured qualitative interviews with urologists practicing in Italy and the UK from February to July 2022. Interviews focussed on undisrupted (usual) practice and disrupted practice (changes made during COVID‐19 restrictions). Codes were generated inductively and were mapped to the 14 domains of the Theoretical Domains Framework. Relevant domains of influence were identified, and the similarities and differences between the UK and Italy were distinguished.ResultsWe identified 10 domains that were influential to ADT prescribing in the UK and eight in Italy. The role of guidance and evidence, the cancer care setting, the patients and the urologist's beliefs and experiences were identified as areas that were influential to ADT prescribing before surgery. Twenty‐one similarities and 22 differences between the UK and Italy, for usual and COVID‐19 practice, were identified across these 10 domains.ConclusionSimilarities and differences influencing ADT prescribing prior to surgery should be considered in behavioural strategy development and tailoring to reduce inappropriate ADT use. We gained an understanding of usual, undistributed care and resource‐limited or disrupted care due to COVID‐19 in two European countries. This gives an indication of how influences on ADT prescribing may change in future resource‐limited circumstances and where efforts can be focused now and in future.

show abstract

Patterns of prescription and adherence to European Association of Urology guidelines on androgen deprivation therapy in prostate cancer: an Italian multicentre cross‐sectional analysis from the Choosing Treatment for Prostate Cancer (CHOICE) study

Cited by 27 publications

References 23 publications

Ensuring Consistent European-Wide Urological Care by the Use of Evidence-Based Clinical Practice Guidelines: Can We Do Better

Ensuring Consistent European-Wide Urological Care by the Use of Evidence-Based Clinical Practice Guidelines: Can We Do Better

Tratamiento del cáncer de próstata en función de la esperanza de vida, la comorbilidad y las guías de práctica clínica

Influences on androgen deprivation therapy prescribing before surgery in high‐risk prostate cancer

Contact Info

Product

Resources

About