Patterns of recurrence and second primary tumors in oral squamous cell carcinoma treated with surgery alone

Liu, Chih-Hsien; Chen, Han-Ju; Wang, Pa-Chun; Chen, Huan-Sen; Chang, Yen‐Liang

doi:10.1016/j.kjms.2013.03.001

Cited by 42 publications

(46 citation statements)

References 19 publications

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“…The rising incidence and survival rates lead to an increasing OCC prevalence, which poses challenges for surveillance care. Patients treated with curative intent receive an intensive follow‐up regimen, comprising at least 17 check‐up visits within 5 years to detect recurrence and second primary head and neck cancers early . Furthermore, because of the negative impact of treatment on oral function, patients will not only rely on their medical specialist, but also on an array of supportive specialties, such as dentists, dieticians and physical therapists.…”

Section: Discussionmentioning

confidence: 99%

Trends in oral cavity cancer incidence, mortality, survival and treatment in the Netherlands

Dijk¹,

et al. 2016

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Information on epidemiology is essential to evaluate care for the growing group of oral cancer patients. We investigated trends in incidence, mortality and relative survival rates for oral cavity cancer (OCC) and its subsites in the Netherlands from 1991 to 2010, and relate these to changes in stage and treatment. Patient (age, sex), tumour (subsite, stage) and treatment characteristics of patients diagnosed with OCC (ICD-O-3: C02-C06) in 1991-2010 were extracted from the Netherlands Cancer Registry. Incidence, mortality and 5-year relative survival rates over time are presented, as well as trends in type of treatment. The incidence of OCC increased with 11.2% (95%CI: 10.9%;11.6%) per year: more strongly in women, stage I and IV disease, and in cancers of the tongue and gum. The mortality rate slightly rose (10.8%, 95%CI: 10.3%;11.3% per year), but differed by subsite. The 5-year relative survival improved from 57% in 1991-1995 to 62% in 2006-2010. The 5-year relative survival was better for women compared with men (64% and 55%, respectively), decreased with increasing stage, was the best for tongue cancer (63%) and the worst for cancer of the gum (56%) and floor of mouth cancer (55%). The relative excess risk of dying was higher for non-surgery-based treatments. Surgery was the main treatment option and the proportion of "surgery only" rose in stage I and III disease. The incidence and, to a lesser extent, mortality of OCC are increasing and therefore, even with slightly improving survival rates, OCC is an increasingly important health problem.The incidence of oral cavity cancer (OCC) is increasing and has replaced laryngeal cancer as the most frequently occurring cancer in the head and neck area in the Netherlands.

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Section: Discussionmentioning

confidence: 99%

Trends in oral cavity cancer incidence, mortality, survival and treatment in the Netherlands

Dijk¹,

et al. 2016

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“…Usually, surgical treatment is preferred in the initial oral cancer, and the cases of progressed oral cancer with cervical lymph node metastasis can be provided with surgical treatment along with chemotherapy and radiation therapy [22]. Previous studies reported that overall survival and disease-specific survival was significantly higher in the surgically treated group compared with no surgery group in oral cavity squamous cell carcinoma [23–25]. Surgery and/or radiation therapy provides disease-specific survival benefit as compared with no therapy within the head and neck region [26].…”

Section: Discussionmentioning

confidence: 99%

Prospective study on factors affecting the prognosis of oral cancer in a Chinese population

et al. 2016

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This study was performed to identify the factors affecting prognosis of oral cancer patients. 1240 pathologically confirmed oral cancer patients were included. The sociodemographic and clinical characteristics of all patients were collected. Univariate and multivariate Cox proportional hazards models were used to assess potential prognostic factors for survival. 1240 oral cancer patients were followed up for 49235.00 person months, and the 5-year overall survival rate was 64.38%. Both univariate and multivariate Cox regression analysis indicated that Body Mass Index < 18.5 kg/m2 (vs 18.5–23.9 kg/m2), age ≥ 55 years (vs < 55 years), clinical stages of II-IV (vs stage I), and poor differentiation (vs well differentiation) were associated with worse survival of oral cancer patients. While surgery (vs non-surgery) and origin of urban area (vs rural area) were protective factors. However, no significant association was found between adjuvant therapy and survival in oral cancer patients.

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“…Empirical studies on follow‐up after treatment for OSCC are scarce and usually combine the data of all HNC's, which have a different etiology, treatment, prognosis, and timing of second events . The available studies on OSCC are small and do not address the question whether specific patient groups are in need of more or less intensive follow‐up …”

Section: Introductionmentioning

confidence: 99%

Time patterns of recurrence and second primary tumors in a large cohort of patients treated for oral cavity cancer

et al. 2019

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Introduction Routine follow‐up after curative treatment of patients with oral squamous cell carcinoma (OSCC) is common practice considering the high risk of second primaries and recurrences (ie second events). Current guidelines advocate a follow‐up period of at least 5 years. The recommendations are not evidence‐based and benefits are unclear. This is even more so for follow‐up after a second event. To facilitate the development of an evidence‐ and personalized follow‐up program for OSCC, we investigated the course of time until the second and subsequent events and studied the risk factors related to these events. Materials and methods We retrospectively studied 594 OSCC patients treated with curative intent at the Head and Neck Cancer Unit of the Radboud University Medical Centre from 2000 to 2012. Risk of recurrence was calculated addressing death from intercurrent diseases as competing event. Results The 1‐, 5‐ and 10‐year cumulative risks of a second event were 17% (95% CI:14%;20%), 30% (95% CI:26%;33%), and 37% (95% CI:32%;41%). Almost all locoregional recurrences occurred in the first 2 years after treatment. The incidence of second primary tumors was relatively stable over the years. The time pattern of presentation of third events was similar. Discussion Our findings support a follow‐up time of 2 years after curative treatment for OSCC. Based on the risk of recurrence there is no indication for a different follow‐up protocol after first and second events. After 2 years, follow‐up should be tailored to the individual needs of patients for supportive care, and monitoring of late side‐effects of treatment.

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Patterns of recurrence and second primary tumors in oral squamous cell carcinoma treated with surgery alone

Cited by 42 publications

References 19 publications

Trends in oral cavity cancer incidence, mortality, survival and treatment in the Netherlands

Trends in oral cavity cancer incidence, mortality, survival and treatment in the Netherlands

Prospective study on factors affecting the prognosis of oral cancer in a Chinese population

Time patterns of recurrence and second primary tumors in a large cohort of patients treated for oral cavity cancer

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