Patterns of response to isoprenaline in asthmatic patients

To establish the presence of a diurnal variation in bronchial responsiveness in asthmatic children, the increase of peak expiratory flow rate (PEFR) following sympathomimetic inhalation and the response to bronchial provocation with histamine and hyperventilation of cold dry air (HVCDA) were studied. Twenty-nine patients (20 boys, nine girls, aged 9.3 to 17.8 years) measured PEFR before and after sympathomimetic inhalation three times a day for four weeks. A further 15 patients (eight boys, seven girls, aged 6.9 to 18.0 years) underwent bronchial provocation testing every six hours for 24 hours. A diurnal variation in bronchodilator responsiveness was demonstrated in 55% of the first group. Mean amplitude was 60.8% of patients' mean increase in PEFR following bronchodilators. On grouped data, bronchodilation was greater in the morning than in the afternoon (p less than 0.0005) or in the evening (p less than 0.0005). A diurnal variation in the response to bronchial provocation was also found in the second group, but the timing of the rhythm depended on the stimulus used. On grouped data, airways were most sensitive to histamine at 0400 hours and most sensitive to HVCDA at 1600 hours. The diurnal variation demonstrated in bronchial responsiveness could not be attributed to changes in baseline airway caliber and was present, despite the patients' taking sufficient medication to control their asthmatic symptoms.

show abstract

Diurnal variation in bronchial responsiveness in asthmatic children

Sly

Landau

1986

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

Assessing bronchodilator responsiveness

Tinkelman¹,

Avner²,

Cooper³

1977

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

Response to frequent low doses of nebulized salbutamol in acute asthma

Robertson

Smith

Beck

et al. 1985

The Journal of Pediatrics

101

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Patterns of response to isoprenaline in asthmatic patients

Cited by 6 publications

References 13 publications

Diurnal variation in bronchial responsiveness in asthmatic children

Diurnal variation in bronchial responsiveness in asthmatic children

Assessing bronchodilator responsiveness

Response to frequent low doses of nebulized salbutamol in acute asthma

Contact Info

Product

Resources

About