Patterns of second recurrence of malignant astrocytomas

Massey, Vickie; Wallner, Kent E.

doi:10.1016/0360-3016(90)90106-t

Cited by 63 publications

(25 citation statements)

References 7 publications

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“…Importantly, those tumors that do not reoxygenate are more likely to fail (60,65), supporting the possibility that even large radiation doses would be insufficient to kill resistant cells. These observations are consistent with the report that 78% and 56% of unifocal tumors recurred within 2.0 and 1.0 cm, respectively, of the presurgical, initial tumor margin, defined as the enhancing edge of the tumor on computed tomography scan (66). Now that hypoxic regions can be prospectively identified by using noninvasive imaging methods (67)(68)(69), treatment methods such as intensity-modulated radiation therapy or proton beams, hypoxia modifying agents such as RSR13 (70), hyperbaric oxygen (71), dodecafluoropentane [DDFP (72)], and tirapazamine (73) become therapeutically relevant.…”

Section: Discussionsupporting

confidence: 93%

Hypoxia Is Important in the Biology and Aggression of Human Glial Brain Tumors

Evans

Judy²,

Dunphy

et al. 2004

Clinical Cancer Research

308

237

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Section: Discussionsupporting

confidence: 93%

Hypoxia Is Important in the Biology and Aggression of Human Glial Brain Tumors

Evans

Judy²,

Dunphy

et al. 2004

Clinical Cancer Research

308

237

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“…12,13 Our data using a pairwise comparison for the individual patient with a center-of-mass approach revealed an approximate incidence of out-of-field recurrences of 20%. This higher number could be due to methodological differences because the determination of distant recurrences in older studies often did not rely on MRI.…”

Section: Discussionmentioning

confidence: 96%

A novel tool to analyze MRI recurrence patterns in glioblastoma

et al. 2008

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At least 10% of glioblastoma relapses occur at distant and even contralateral locations. This disseminated growth limits surgical intervention and contributes to neurological morbidity. Preclinical data pointed toward a role for temozolomide (TMZ) in reducing radiotherapy-induced glioma cell invasiveness. Our objective was to develop and validate a new analysis tool of MRI data to examine the clinical recurrence pattern of glioblastomas. MRIcro software was used to map the location and extent of initial preoperative and recurrent tumors on MRI of 63 patients in the European Organisation for Research and Treatment of Cancer (EORTC) 26981/22981/National Cancer Institute of Canada (NCIC) CE.3 study into the same stereotaxic space. This allowed us to examine changes of site and distance between the initial and the recurrent tumor on the group level. Thirty of the 63 patients were treated using radiotherapy, while the other patients completed a radiotherapy-plus-TMZ treatment. Baseline characteristics (median age, KPS) and outcome data (progression-free survival, overall survival) of the patients included in this analysis resemble those of the general study cohort. The patient groups did not differ in the promoter methylation status of methyl guanine methyltransferase (MGMT). Overall frequency of distant recurrences was 20%. Analysis of recurrence patterns revealed no difference between the groups in the size of the recurrent tumor or in the differential effect on the distance of the recurrences from the preoperative tumor location. The data show the feasibility of groupwise recurrence pattern analysis. An effect of TMZ treatment on the recurrence pattern in the EORTC 26981/22981/NCIC CE.3 study could not be demonstrated.

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“…Unfortunately, these tumors, which mostly infiltrate locoregionally without disseminating out of the brain, are quite refractory to current treatment (Burger, 1983;Kelly et al, 1987;Wallner et al, 1989;Massey and Wallner, 1990). Despite advances in surgical techniques, radiation, and chemotherapy, the median survival time remains less than 1 year.…”

Section: Introductionmentioning

confidence: 96%

Novel Three-Pronged Strategy to Enhance Cancer Cell Killing in Glioblastoma Cell Lines: Histone Deacetylase Inhibitor, Chemotherapy, and Oncolytic Adenovirus dl520

et al. 2006

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Resistance to radiation and chemotherapy remains an obstacle to the treatment of brain tumors. We have demonstrated that the replication-deficient adenovirus d1520, which lacks the E1A 13S protein, replicates efficiently and exhibits oncolytic potential in multidrug-resistant cells with nuclear localization of the human transcription factor YB-1. However, besides others, key factors regarding oncolytic virotherapy are limited tumor transduction rate and low replication efficiency. The objective of this study was to determine whether the chemotherapeutic agent irinotecan, by enhancing nuclear localization of YB-1, and the histone deacetylase inhibitor trichostatin A, by upregulating coxsackievirus-adenovirus receptor (CAR) expression, could augment replication of and cell lysis by adenovirus dl520 in glioblastomas in vitro. We found that trichostatin A upregulated CAR expression and that irinotecan caused increased nuclear localization of YB-1 in both glioblastoma cell lines. Irinotecan alone, and trichostatin A alone, enhanced replication of and cell lysis by dl520. Importantly, when combining both agents, the replication efficiency (maximum, 27-fold) and induction of cytopathic effect (maximum, 3.8-fold) of dl520 were further augmented significantly. These results support the hypothesis that the enhanced oncolytic effect of dl520, after incubation with chemotherapeutic agents, is mediated by an increased accumulation of YB-1 in the nucleus (due to irinotecan) and by upregulation of CAR (due to trichostatin A). Thus, therapy combining virotherapy, chemotherapy, and histone deacetylase inhibitor treatment is a novel approach to enhance the oncolytic efficacy of dl520.

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Patterns of second recurrence of malignant astrocytomas

Cited by 63 publications

References 7 publications

Hypoxia Is Important in the Biology and Aggression of Human Glial Brain Tumors

Hypoxia Is Important in the Biology and Aggression of Human Glial Brain Tumors

A novel tool to analyze MRI recurrence patterns in glioblastoma

Novel Three-Pronged Strategy to Enhance Cancer Cell Killing in Glioblastoma Cell Lines: Histone Deacetylase Inhibitor, Chemotherapy, and Oncolytic Adenovirus dl520

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