Patterns of simultaneous patch test reactions to thiurams and dithiocarbamates in 164 patients

Aalto‐Korte, Kristiina; Pesonen, Maria

doi:10.1111/cod.12687

Cited by 32 publications

(36 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been proposed to reintroduce carba mix into the European baseline series . However, in the present study, as has been reported by others, isolated dithiocarbamate reactions seem to be rare . Thiurams seem to be better markers for contact allergy to both thiurams and dithiocarbamates .…”

Section: Discussionsupporting

confidence: 63%

“…Patch testing with DPG is considered to cause a number of irritant reactions when it is tested 1% pet . In the present study, testing with 2% pet.…”

Section: Discussionmentioning

confidence: 92%

“…Possibly, the different conditions used for preparing the 2 test preparations could have influenced the result. A lower test concentration of DPG, namely 0.33% pet., is less irritant than DPG 1.0%, but might reduce the detection of contact allergy. In our experience, even weak allergic reactions can be of clinical significance, as we have seen several cases with weak contact allergy to DPG in which switching to gloves free from DPG was followed by disappearance of the HE.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, in recent years, the frequency of contact allergy to diphenylguanidine (DPG) in surgical gloves has increased, and has probably contributed to the increase in the frequency of positive test reactions to carba mix, as DPG is part of carba mix. However, DPG has been reported to frequently cause false‐positive or irritant reactions …”

Section: Introductionmentioning

confidence: 99%

“…16,17 However, thiurams remain among the most common rubber contact allergens found in HCWs. 11,15,18,19 Thiurams have been reported to be good markers for contact allergy to dithiocarbamates, 20,21 possibly because of chemical structural similarities. Moreover, in recent years, the frequency of contact allergy to diphenylguanidine (DPG) in surgical gloves has increased, 22,23 and has probably contributed to the increase in the frequency of positive test reactions to carba mix, [24][25][26] as DPG is part of carba mix.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Hand eczema and occupational contact allergies in healthcare workers with a focus on rubber additives

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 63%

“…Patch testing with DPG is considered to cause a number of irritant reactions when it is tested 1% pet . In the present study, testing with 2% pet.…”

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Hand eczema and occupational contact allergies in healthcare workers with a focus on rubber additives

et al. 2018

View full text Add to dashboard Cite

show abstract

Systematic Identification of Copositivity Groups in Standard Series Patch Testing Through Hierarchical Clustering

Yang,

Yiannias,

Voss

et al. 2023

JAMA Dermatol

View full text Add to dashboard Cite

ImportancePatients are frequently copositive for multiple allergens simultaneously, either due to chemical similarity or simultaneous sensitization. A better understanding of copositivity groups would help guide contact avoidance.ObjectiveTo use patient data to systematically determine copositivity groups in the Mayo Clinic Standard Series.Design, Setting, and ParticipantsIn this retrospective cross-sectional analysis, the Mayo Clinic patch test database was queried for pairwise copositivity rates in the 80 allergen Mayo Clinic Standard Series between 2012 and 2021. Data were collected from 3 tertiary care sites of the Mayo Clinic Contact Dermatitis Group and a total of 5943 patients were included, comprising all patients undergoing patch testing to the Mayo Clinic Standard Series allergens.Main Outcomes and MeasuresCopositivity rates between every 2 allergens in the 80-allergen Mayo Clinic Standard Series were estimated. After background correction, copositivity rates were analyzed using unsupervised hierarchical clustering to systematically identify copositivity groups in an unbiased manner.ResultsOverall, 394 921 total patches were applied to 5943 patients (4164 [70.1%] women, 1776 [29.9%] men, with a mean [SD] age of 52.3 [18.8] years ), comprising 9545 positive reactions. After background correction based on overall positivity rates, hierarchical clustering revealed distinct copositivity groups. Many were supported by prior literature, including formaldehyde releasers, cobalt-nickel-potassium dichromate, acrylates, 3-dimethylaminopropylamine-amidoamine-oleamidopropyl dimethylamine, alkyl glucosides, budesonide-hydrocortisone-17-butyrate, certain fragrances, compositae-sesquiterpene lactone mix, mercapto mix-mercaptobenzothiazole, carba mix-thiuram mix, and disperse orange-p-phenylenediamine. However, novel associations were also found, including glutaraldehyde-sorbitan sesquioleate, benzalkonium chloride-neomycin-bacitracin, bronopol-methylchloroisothiazolinone-methylisothiazolinone, and benzoic acid-iodopropynyl butylcarbamate.Conclusions and RelevanceThis retrospective cross-sectional analysis found that copositivity rates varied between allergens; allergens with extremely high positivity rates demonstrated nonspecific copositivity to multiple other allergens. Background correction based on positivity rates followed by hierarchical clustering confirmed prior known copositivity groups, contaminants and/or excipients leading to copositivity, and novel associations to guide contact avoidance.

show abstract

The European Baseline Series

Uter¹,

Wilkinson²,

Gonçalo³

2020

Contact Dermatitis

View full text Add to dashboard Cite

Patterns of simultaneous patch test reactions to thiurams and dithiocarbamates in 164 patients

Cited by 32 publications

References 22 publications

Hand eczema and occupational contact allergies in healthcare workers with a focus on rubber additives

Hand eczema and occupational contact allergies in healthcare workers with a focus on rubber additives

Systematic Identification of Copositivity Groups in Standard Series Patch Testing Through Hierarchical Clustering

The European Baseline Series

Contact Info

Product

Resources

About