Patterns of substance use among Argentinean adolescents and analysis of the effect of age at first alcohol use on substance use behaviors

Pilatti, Angelina; Godoy, Juan Carlos; Brussino, Silvina; Pautassi, Ricardo Marcos

doi:10.1016/j.addbeh.2013.08.007

Cited by 40 publications

(25 citation statements)

References 13 publications

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“…This "early debut" effect (i.e., the early the onset of alcohol use, the greater the later problematic use of alcohol) has been shown across cultures, and is illustrated by a seminal clinical work (DeWit et al, 2000), that reported 16% of alcohol dependence in those who began drinking at 11-12 years, but only 1% in those who started at age 19. Our studies (Pilatti et al, 2013) have also indicated that college students who started drinking alcohol at ≤15 years exhibit significantly more alcohol use and drunkenness than those who had their first contact with the drug after age 15. Perhaps more important, another clinical study has recently shown (Vera et al, 2019) that the initial contact with alcohol is not as relevant, as a predictive milestone for subsequent problematic substance use, as the first intoxication or drunkenness episode.…”

Section: Introductionsupporting

confidence: 62%

Binge-Like, Naloxone-Sensitive, Voluntary Ethanol Intake at Adolescence Is Greater Than at Adulthood, but Does Not Exacerbate Subsequent Two-Bottle Choice Drinking

Salguero

Suarez

Luque

et al. 2020

Front. Behav. Neurosci.

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The present study assessed the effects of ethanol exposure during adolescence or adulthood. We exposed Wistar rats, males or females, to self-administered 8-10% (v/v) ethanol (BINGE group) during the first 2 h of the dark cycle, three times a week (Monday, Wednesday, and Friday) during postnatal days (PDs) 32-54 or 72-94 (adolescent and adults, respectively). During this period, controls were only handled, and a third (IP) condition was given ethanol intraperitoneal administrations, three times a week (Monday, Wednesday, and Friday), at doses that matched those self-administered by the BINGE group. The rats were tested for ethanol intake and preference in a two-bottle (24 h long) choice test, shortly before (PD 30 or 70) and shortly after (PD 56 or 96) exposure to the binge or intraperitoneal protocol; and then tested for free-choice drinking during late adulthood (PDs 120-139) in intermittent two-bottle intake tests. Binge drinking was significantly greater in adolescents vs. adults, and was blocked by naloxone (5.0 mg/kg) administered immediately before the binge session. Mean blood ethanol levels (mg/dl) at termination of binge session 3 were 60.82 ± 22.39. Ethanol exposure at adolescence, but not at adulthood, significantly reduced exploration of an open field-like chamber and significantly increased shelter-seeking behavior in the multivariate concentric square field. The rats that had been initially exposed to ethanol at adolescence drank, during the intake tests conducted at adulthood, significantly more than those that had their first experience with ethanol at adulthood, an effect that was similar among BINGE, IP and control groups. The study indicates that binge ethanol drinking is greater in adolescent that in adults and is associated with heightened ethanol intake at adulthood. Preventing alcohol access to adolescents should reduce the likelihood of problematic alcohol use or alcohol-related consequences.

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Section: Introductionsupporting

confidence: 62%

Binge-Like, Naloxone-Sensitive, Voluntary Ethanol Intake at Adolescence Is Greater Than at Adulthood, but Does Not Exacerbate Subsequent Two-Bottle Choice Drinking

Salguero

Suarez

Luque

et al. 2020

Front. Behav. Neurosci.

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“…The present study focused on ethanol-related behaviors during adolescence, a developmental stage in which ethanol experimentation and escalation usually occurs [28]. The aims of the present study were to (a) assess the relationship between measures of ethanol-induced activity and anxiolysis in the OF, EPM, and LDB, (b) analyze ethanol intake as a function of previous ethanol exposure, and (c) analyze associations between ethanol intake and behavioral responsiveness in these apparatus.…”

Section: Discussionmentioning

confidence: 99%

Relationship between ethanol-induced activity and anxiolysis in the open field, elevated plus maze, light-dark box, and ethanol intake in adolescent rats

Acevedo

Nizhnikov

Molina

et al. 2014

Behavioural Brain Research

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It is yet unclear if ethanol-induced motor stimulation in the open field (OF) merely reflects psychomotor stimulating effects of the drug or if this stimulation is driven or modulated by ethanol’s antianxiety properties. In the present study, adolescent rats were administered with different ethanol doses or remained untreated. They were sequentially assessed in the OF, elevated plus maze (EPM), and light-dark box (LDB) and then assessed for ethanol intake. The aims were to assess the relationship between measures of ethanol-induced activity and anxiolysis, analyze ethanol intake as a function of prior ethanol exposure, and associate behavioral responsiveness in these apparatus with ethanol intake during adolescence. The results suggested that the enhanced exploration of the OF observed after 2.5 and 3.25 g/kg ethanol reflected a motor-stimulating effect that appeared to be relatively independent of anxiolysis. The 1.25 g/kg dose induced motor stimulation in the OF and anti-anxiety effects in the EPM, but these effects were relatively independent. The 0.5 g/kg ethanol dose exerted significant anxiolytic effects in the EPM in the absence of stimulating effects in the OF. A multivariate regression analysis indicated that adolescents with a higher frequency of rearing behavior in the OF, higher percentage of open arm entries in the EPM, and lower propensity to enter the central area of the OF exhibited greater ethanol intake. These results indicate that the OF is a valid procedure for the measurement of ethanol-induced stimulation, and provide information towards characterizing subpopulations of adolescents at risk for initiating alcohol drinking.

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“…Those who begin drinking in their teenage years are also more likely to experience alcohol‐related unintentional injuries (such as motor vehicle injuries, falls, burns, drowning) than those who begin drinking at a later age […]’. Also, empirical papers published recently in peer‐reviewed journals refer to the importance of focusing on AFD .…”

Section: Introductionmentioning

confidence: 99%

Is ‘age at first drink’ a useful concept in alcohol research and prevention? We doubt that

Kuntsche

Rossow²,

Engels

et al. 2015

Addiction

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Patterns of substance use among Argentinean adolescents and analysis of the effect of age at first alcohol use on substance use behaviors

Cited by 40 publications

References 13 publications

Binge-Like, Naloxone-Sensitive, Voluntary Ethanol Intake at Adolescence Is Greater Than at Adulthood, but Does Not Exacerbate Subsequent Two-Bottle Choice Drinking

Binge-Like, Naloxone-Sensitive, Voluntary Ethanol Intake at Adolescence Is Greater Than at Adulthood, but Does Not Exacerbate Subsequent Two-Bottle Choice Drinking

Relationship between ethanol-induced activity and anxiolysis in the open field, elevated plus maze, light-dark box, and ethanol intake in adolescent rats

Is ‘age at first drink’ a useful concept in alcohol research and prevention? We doubt that

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