Patterns of Surgery in Patients Belonging to Amsterdam-Positive Families

Dalen, Ralph Van; Church, James M.; McGannon, Ellen; Fay, Susan; Burke, C; Clark, Beth Z.

doi:10.1007/s10350-004-6619-9

Cited by 42 publications

(21 citation statements)

References 15 publications

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“…Several studies reported that the risk of developing metachronous CRC varies between 22% and 41%. [7][8][9] We found a 10-year cumulative risk of developing CRC after partial colectomy of 16% in comparison with 3% after subtotal colectomy. 10 Moreover, with the use of a mathematical (Markov) model, we observed that subtotal colectomy was associated with a slightly increased life expectancy.…”

mentioning

confidence: 84%

Quality of Life After Surgery for Colon Cancer in Patients With Lynch Syndrome; Partial Versus (Sub)Total Colectomy

Haanstra¹,

Cappel²,

Vanhoutvin³

et al. 2011

Gastroenterology

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mentioning

confidence: 84%

Quality of Life After Surgery for Colon Cancer in Patients With Lynch Syndrome; Partial Versus (Sub)Total Colectomy

Haanstra¹,

Cappel²,

Vanhoutvin³

et al. 2011

Gastroenterology

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“…The tumor type, location, stage and progression, as well as the patient's general health status should be considered. The treatment of choice involves curative surgical resection of each cancer, followed by radiotherapy and chemotherapy (16)(17)(18). The prognosis should be determined independently as a function of the tumor stage and treatment results for each cancer.…”

Section: Discussionmentioning

confidence: 99%

Case report of concurrent primary malignancies of the breast and nasopharynx

Pan

Zhu

2012

Oncology Letters

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Abstract. The aim of this study was to report a case of concurrent primary malignancies of the breast and nasopharynx and discuss the potential relationship between Epstein-Barr virus (EBV) infection and breast cancer. A 39-year-old female presented with a palpable mass present for 1 year in her left breast. Immunohistochemical staining was performed and the results showed that the tumor cells were immunopositive for the estrogen receptor, progesterone receptor and p53 protein, and markedly positive for C-erb B2. In addition, 30% of the tumor cells were positive for the Ki-67 antigen. Blood test results revealed that EBV-CA-IgG was present and EBV-EA-IgG was reactivated. The patient was diagnosed with breast cancer (T1N0M0) and EBV infection. A mastectomy with axillary clearance was performed on the left breast. Histopathological examination provided evidence of invasive ductal adenocarcinoma. Further evaluation due to epistaxis following the breast surgery resulted in a diagnosis of nasopharyngeal carcinoma (T2N1M0). Histopathology showed a non-keratinizing undifferentiated carcinoma. The patient was treated with chemoradiotherapy for nasopharyngeal carcinoma. Twelve months following surgery and chemoradiotherapy the patient was assessed at the Cancer Hospital of Guangxi Medical University outpatient clinic and no evidence of relapse or metastasis was found. Thus, EBV infection may be involved in the pathogenesis of breast cancer, as observed in nasopharyngeal carcinoma. IntroductionThe mechanisms responsible for the appearance of multiple primary cancers remain unclear. Among the factors most frequently involved are genetic susceptibility, the immune system and intensive exposure to carcinogens, including chemical and biological carcinogens and radiation.Breast cancer is the most common neoplastic disease of women in the Western world. In developed countries, more than 200 cases are diagnosed annually per 100,000 women. The etiology and mechanisms of breast cancer are poorly understood. Well-known risk factors, including those that affect circulating sex hormones and genetic background can only explain approximately 50% of all breast cancer cases. Among the remaining 50% of cases, findings of numerous studies have suggested that Epstein-Barr virus (EBV) infection may be a causal factor (1-4).EBV is a ubiquitous γ herpes virus and infects 90% of the population. In the majority of individuals, the virus persists for life in the memory B-cell pool (5) with no adverse health consequences. The virus is essentially a B-lymphotropic agent and is associated with malignancies of B-cell origin, including Burkitt's lymphoma. However, epithelial cell infection clearly occurs in vivo, as EBV is also associated with malignancies of epithelial origin, such as nasopharyngeal carcinoma (NPC). In Burkitt's lymphoma and NPC, epidemiological and molecular virological data favor the role of the virus as a cofactor in tumor initiation and/or development. The involvement of EBV has been demonstrated by the findings of EBNA-1 express...

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“…There is potentially a high risk of metachronous colorectal cancer if an initial cancer in a LS patient (defined according to Amsterdam criteria) is treated by partial colectomy. However, this risk can be lowered, either by performing a total colectomy at the time of initial surgery or possibly by effective postoperative surveillance (24). Both of our cases had 3 first degree relatives suffering from colon cancer and 2 successive generations were found to be effected.…”

Section: Discussionmentioning

confidence: 99%

Lynch Syndrome; A Tale of Two Cases Sharing The Same Destiny with Metachronous Tumor Development

Çakmak¹,

Gençoğlu²,

Sever³

et al. 2017

MJWBS

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Lynch syndrome (LS), is an autosomal dominant disease, accounts for approximately 1 to 2 percent of all colorectal cancers. Individuals with LS tend to develop cancers at a relatively young age and are at risk of multiple synchronous and metachronous malignancies. Several clinical criteria have been identified to assist in diagnosing LS. Subtotal or total colectomy is the procedure of choice for these patients as a result of high risk of multiplicity of lesions and metachronous tumors in time and colonoscopic surveillance is strictly recommended. Nevertheless, when the diagnosis of LS is neglected and the cancer is regarded as sporadic and treated accordingly, patients experience insufficient surgical interventions associated with metachronous malignancies, just like these two cases we report herein. The exact identification of the cases might decrease the number of misdiagnosis in this way and might decline the metachronous tumor development, with resulting in decreased morbidity, increased life quality, and improved survival. The article herein aimed to underline the importance of basic medical examination and colonoscopic surveillance that all of the clinicians dealing with cancer treatment should be aware of and the responsibility of surgical education centers on teaching the principles of cancer management to forthcoming surgeons during residancy. © 2017 Bulent Ecevit University All rights reserved. Gönderilme Tarihi: 20.11.2016 Düzeltme 02.01.2017 Kabul: 05.03.2017 Lynch Sendromu (LS) otozomal dominant bir hastalık olup tüm kolorektal kanserlerin %1-2' sini oluşturmaktadır. LS'li bireyler göreceli olarak genç yaşta kanser gelişimine yatkındır ve multipl senkron ve metakron malignite gelişme riski altındalardır. LS tanısı koymaya yardımcı birkaç klinik kriter tanımlanmıştır. Multipl lezyonlar ve metakron tümörlerin zamanla yüksek risk olması nedeniyle bu hastalar için prosedür seçimi total ya da subtotal kolektomidir ve kolonoskopik takip şiddetle önerilmektedir. Fakat LS tanısı atlandığında ve kanser sporadik olarak addedilip buna göre tedavi edildiğinde, bu sunumdaki vakalarda olduğu gibi, hastalar metakron malignitelerle ilişkili olarak yetersiz cerrahi girişimleri deneyimlemektedirler. Vakaların kesin olarak tanımlanması; bu yolla yanlış tanıların sayısını azaltacak; azalmış mortalite, artmış hayat kalitesi ve geliştirilmiş hayat beklentisi ile sonuçlanacak olan metakron tümör gelişimini azaltacaktır. Bu makalede temel muayene ve kolonoskopik takibin öneminin kanser tedavisi ile ilgilenen tüm klinisyenlerin farkında olması; ayrıca ihtisas sürecindeki cerrahlara eğitim altındayken kanser yönetiminin prensiplerini öğreten cerrahi eğitim merkezlerinin sorumluluğunun öneminin altının çizilmesi hedeflemiştir.

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Patterns of Surgery in Patients Belonging to Amsterdam-Positive Families

Cited by 42 publications

References 15 publications

Quality of Life After Surgery for Colon Cancer in Patients With Lynch Syndrome; Partial Versus (Sub)Total Colectomy

Quality of Life After Surgery for Colon Cancer in Patients With Lynch Syndrome; Partial Versus (Sub)Total Colectomy

Case report of concurrent primary malignancies of the breast and nasopharynx

Lynch Syndrome; A Tale of Two Cases Sharing The Same Destiny with Metachronous Tumor Development

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