Patterns of vascular response immediately after passive mobilization in patients with sepsis: an observational transversal study

Kawakami, Débora Mayumi de Oliveira; Bonjorno-Junior, José Carlos; Destro, Tamara Rodrigues da Silva; Biazon, Thaís Marina Pires de Campos; Garcia, Naiara Molina; Bonjorno, Flávia Cristina Rossi Caruso; Borghi‐Silva, Audrey; Mendes, Renata Gonçalves

doi:10.1007/s10554-021-02402-0

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…Our findings reporting associations between CEF and select systemic markers of inflammation and adhesion are similar to SEF observations reported among HIV-uninfected people. CRP levels have been inversely correlated with brachial FMD, 28,30 and IFN-γ has been shown to impair endothelial glucose metabolism by altered tryptophan catabolism destabilizing hypoxia-inducible factor 1α, deplete nicotinamide adenine dinucleotide, and result in a metabolic shift toward increased fatty acid oxidation, which can lead to adverse endothelial function. 31 Among PWH, studies reporting associations between FMD and traditional cardiovascular risk factors, inflammatory markers, and other subclinical CVD measures have shown variable results.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Impaired Coronary Endothelial Function and Systemic Markers of Inflammation in People Living With HIV

Bagchi

Kwapong

Schär

et al. 2023

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background: People with HIV (PWH) are at an increased risk of cardiovascular disease, partially believed to be related to chronically elevated systemic inflammation. Abnormal systemic endothelial function (SEF) and coronary endothelial function (CEF) develop early in atherogenesis and predict adverse events. It is unknown whether abnormal CEF is related to systemic inflammation in PWH. Methods:In this substudy of a prior randomized controlled trial in PWH without prior clinical coronary artery disease suppressed on antiretroviral therapy with CEF as a primary end point (N = 82), we investigated the associations between baseline serum markers of inflammation and adhesion and baseline CEF, assessed by noninvasive MRI measures of percentage changes in coronary blood flow and cross-sectional area during isometric handgrip exercise, and SEF using brachial ultrasound for flow-mediated dilation. We also evaluated whether baseline marker levels were associated with CEF after 8 weeks in the placebo group (N = 40).Results: CEF measures were abnormal at baseline, based on trial entry criteria. A higher value of CEF was directly associated with levels of interleukin 10, whereas CEF at baseline was inversely associated with E-selectin. Worse CEF at 8 weeks was directly associated with baseline tumor necrosis factor alpha, intercellular adhesion molecule 1, C-reactive protein, interferon gamma and sICAM-3. SEF at baseline or 8 weeks was not associated with any baseline markers. Conclusion:Coronary but not systemic endothelial dysfunction was significantly associated with select markers of inflammation and adhesion in PWH. Furthermore, CEF but not SEF at 8 weeks was associated with baseline levels of inflammation. Our findings suggest that abnormal CEF and systemic markers of inflammation are linked in PWH.

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Section: Discussionmentioning

confidence: 99%

The Relationship Between Impaired Coronary Endothelial Function and Systemic Markers of Inflammation in People Living With HIV

Bagchi

Kwapong

Schär

et al. 2023

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…Although changes in fractal characteristics of EEG as a measure of DOA have been published [ 33 ] and many studies using DFA and other nonlinear methods of HRV to estimate the cardiac function of patients and the physiological status of athletes are reported [ 27 , 34 , 35 , 36 ], little attention has been devoted to fractal characteristics of HRV during different anesthesia state. In the present study, we attempted to investigate the changes in DFA induced by intravenous propofol, inhalational desflurane, and spinal anesthesia and compared them with parameters derived from traditional spectral analysis.…”

Section: Introductionmentioning

confidence: 99%

Fractal Properties of Heart Rate Dynamics: A New Biomarker for Anesthesia—Biphasic Changes in General Anesthesia and Decrease in Spinal Anesthesia

Lan

Shieh

Yeh

et al. 2022

Sensors

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Processed electroencephalogram (EEG) has been considered a useful tool for measuring the depth of anesthesia (DOA). However, because of its inability to detect the activities of the brain stem and spinal cord responsible for most of the vital signs, a new biomarker for measuring the multidimensional activities of the central nervous system under anesthesia is required. Detrended fluctuation analysis (DFA) is a new technique for detecting the scaling properties of nonstationary heart rate (HR) behavior. This study investigated the changes in fractal properties of heart rate variability (HRV), a nonlinear analysis, under intravenous propofol, inhalational desflurane, and spinal anesthesia. We compared the DFA method with traditional spectral analysis to evaluate its potential as an alternative biomarker under different levels of anesthesia. Eighty patients receiving elective procedures were randomly allocated different anesthesia. HRV was measured with spectral analysis and DFA short-term (4–11 beats) scaling exponent (DFAα1). An increase in DFAα1 followed by a decrease at higher concentrations during propofol or desflurane anesthesia is observed. Spinal anesthesia decreased the DFAα1 and low-/high-frequency ratio (LF/HF ratio). DFAα1 of HRV is a sensitive and specific method for distinguishing changes from baseline to anesthesia state. The DFAα1 provides a potential real-time biomarker to measure HRV as one of the multiple dimensions of the DOA.

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Patterns of vascular response immediately after passive mobilization in patients with sepsis: an observational transversal study

Cited by 2 publications

References 36 publications

The Relationship Between Impaired Coronary Endothelial Function and Systemic Markers of Inflammation in People Living With HIV

The Relationship Between Impaired Coronary Endothelial Function and Systemic Markers of Inflammation in People Living With HIV

Fractal Properties of Heart Rate Dynamics: A New Biomarker for Anesthesia—Biphasic Changes in General Anesthesia and Decrease in Spinal Anesthesia

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