Patterns of wound colonisation in patients with peripheral vascular disease

Chesham, J.; Platt, D. J.

doi:10.1016/s0163-4453(87)91326-0

Cited by 9 publications

(2 citation statements)

References 6 publications

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“…Aside from the underlying causative factors that result in the formation of ulcers, another important aspect in their chronicity is concurrent bacterial colonization or infection of the ulcerated area 15 . Wounds are usually colonized by the commensal skin flora but pathogenic bacterial species are also commonly implicated 16,17 . Colonization of a wound is not itself a barrier to wound healing 15 ; however, repeated infections have been shown to cause increased proinflammatory cytokines and matrix metallopeptidases, decreased tissue inhibition of these peptidases and decreased levels of growth factors—these changes have been hypothesized to be the underlying causes of wound chronicity 18 …”

mentioning

confidence: 99%

Novel noninvasive identification of biomarkers by analytical profiling of chronic wounds using volatile organic compounds

Thomas¹,

Riazanskaia²,

Cheung³

et al. 2010

Wound Repair Regeneration

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A complex profile of volatile organic compounds ("VOC"s) emanates from human skin, which is altered by changes in the body's metabolic or hormonal state, the external environment, and the bacterial species colonizing the skin surface. The aim of this study was to compare VOC profiles sampled from chronic leg wounds with those from asymptomatic skin. Five participants with chronic arterial leg ulcers were selected. VOC samples were obtained using polydimethylsilicone membranes ("skin-patch method") and analyzed by gas chromatography-ion trap mass spectrometry. Resultant data were analyzed using multivariate analysis and mass spectral matches were compared against the National Institute of Standards and Technology database. Principal component analysis showed differences in profiles obtained from healthy skin and boundary areas and between profiles from healthy skin and lesion samples (p<0.05). Partial least squares for discriminant analysis gave an average prediction accuracy of 73.3% (p<0.05). Mass spectral matching (verified against microbial swab results) identified unique VOCs associated with each sample area, wound bacterial colonization, and ingested medications. This study showcases a reproducible, robust, noninvasive methodology that is applicable in a clinical setting and may offer a new, hitherto unexplored, class of biochemical markers underpinning the metabolism of chronic wounds.

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mentioning

confidence: 99%

Novel noninvasive identification of biomarkers by analytical profiling of chronic wounds using volatile organic compounds

Thomas¹,

Riazanskaia²,

Cheung³

et al. 2010

Wound Repair Regeneration

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“…However, repeated infections cause in- Apart from the underlying causative factors that result in the formation of pressure ulcers, another important aspect in their chronicity is the concurrent bacterial colonization or infection of the ulcerated area. Wounds are usually colonized by the commensal skin flora, but pathogenic bacterial species are also commonly involved [83]. Colonization of a wound is not itself a barrier to wound healing.…”

Section: Voc Biomarkers In a Chronic Woundmentioning

confidence: 99%

Emerging Strategies Based on Sensors for Chronic Wound Monitoring and Management

et al. 2022

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Pressure ulcers (PUs) are a serious global health challenge, affecting a large section of the population and putting immense pressure on healthcare systems. Sensor-based diagnostic tools and monitoring systems have emerged as a potential non-invasive solution to reduce the occurrence of new cases of PUs and promise a significant reduction in treatment expenditure and time. In this endeavour, the present manuscript reviews the advancements made in the last decade in the development and commercial adoption of different sensor systems for PU-associated chronic wound management. Different types of smart sensor systems have been developed in which pressure, chemical, and optical sensors have witnessed a lot of interest and significant advancement among research communities and industries alike. These sensors utilize a host of nanomaterial-based sensing materials, flexible support, diverse transducing modes, and different device designs to achieve high sensitivity and selectivity for skin pressure, temperature, humidity, and biomarkers released from the wound. Some of these sensor’s array-based electronic skin (e-skin) has reached the stage of commercialization and is being used in commercial products, such as smart bandages, shoes, watches, and mattress among others. Nonetheless, further innovations are necessary in the direction of associating multiple types of sensor arrays, particularly pressure and chemical sensor-based e-skins in a microsystem for performing real-time assessment of all the critical wound parameters.

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Clinical and Bacteriological Advantages in the Use of Occlusive Dressings

Hermans¹,

Hutchinson²

1990

Pathogenesis of Wound and Biomaterial-Associated Infections

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Patterns of wound colonisation in patients with peripheral vascular disease

Cited by 9 publications

References 6 publications

Novel noninvasive identification of biomarkers by analytical profiling of chronic wounds using volatile organic compounds

Novel noninvasive identification of biomarkers by analytical profiling of chronic wounds using volatile organic compounds

Emerging Strategies Based on Sensors for Chronic Wound Monitoring and Management

Clinical and Bacteriological Advantages in the Use of Occlusive Dressings

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