Paul Gerson Unna

Roberts, Helen; Walker, Norman

doi:10.1111/j.1365-2133.1929.tb09329.x

Cited by 4 publications

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“…On January 29, 1929, 4 days after he revised the manuscript of a brief autobiography, Unna died at the age of 78 from an attack of influenza. [9] As a tribute to this great legend, Professor Paul Gerson Unna Academy was founded in Germany in 2016, where a range of current, practice-oriented continuing education courses are delivered with exchange of knowledge and experience. Dermatology as an outstanding field of medicine would have never achieved the present enlightened status, if not for the hard work, dedication, passion, enthusiasm, and commitment by one of the unparalleled brains ever lived, Paul Gerson Unna.…”

Section: Discussionmentioning

confidence: 99%

“…Several stains have been prepared by Unna which included one for demonstrating fungus in smear preparations, Unna stain, an alkaline methylene blue stain for plasma cells, Unna-Pappenheim stain, a contrast stain to detect RNA and DNA (in tissue sections) and to demonstrate plasma cells and Unna-Taenzer stain, an orcein solution for elastic tissue. [9] 6. Unna mark (salmon patch, nevus flammeus, stork bite, angel's kiss) -A benign capillary vascular malformation present at birth on the nape of the neck in 25%-50% of normal infants.…”

Section: Workmentioning

confidence: 99%

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Paul Gerson Unna (1850–1929) – Genius of all times

Gangan¹

2021

JSSTD

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Paul Gerson Unna, one of the leading dermatologists of Central Europe, was way ahead of his time. The originality of this meticulous researcher always reflected in his works on anatomy and histology of the skin. Field of dermatology was made very attractive and appealing to many at that time by his first book on histopathology. His revolutionary Unna boot was only a minor invention when compared to his extensive contribution to the educational research and therapeutic dermatology.

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Section: Discussionmentioning

confidence: 99%

Section: Workmentioning

confidence: 99%

Paul Gerson Unna (1850–1929) – Genius of all times

Gangan¹

2021

JSSTD

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Bibliographic landmarks in the history of dermatology

Potter

2003

Journal of the American Academy of Dermatology

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The Mystical Effects of Dermatological Vehicles

Surber

Smith

2005

Dermatology

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Topical treatment of the skin is as old as the evolution of man. Instinctively, we try to treat a skin injury or irritation with cooling or soothing substances. Even animals lick their wounds, trusting instinctively in the healing power of saliva. When did this archaic pattern of treatment take the gigantic leap from folk medicine to modern drug therapy? This text illustrates the evolution of topical dermatological vehicles, their application (guidelines) and future use. In particular, a phenomenon that has so far been ignored in product development and clinical testing is the vehicle metamorphosis. In clinical and experimental situations, most dermatological vehicles undergo considerable changes after they have been removed from the primary container and are applied to the skin. Subsequently, the initial structural matrix, and the quantitative composition of the vehicle, will most likely change during and after the mechanical shear associated with application of the product and/or evaporation of ingredients. This natural, but highly dynamic process will generate mini-environments for the active moiety that are difficult to predict and that are crucial to the fate of the active moiety. Despite the reasonable wishes of formulators, clinicians, patients and customers, there are still no universal vehicles. Each drug, at each concentration, requires a different vehicle for optimized therapy. Stability and compatibility of excipients and active moiety are crucial for any commercially available pharmaceutical or cosmetic formulation, together with local and systemic safety of all components. Nonetheless, more diverse and molecularly complex classes of new dermatological vehicles are continuously being researched and refined. The scientific progress has been remarkable when one considers the simple emulsion mixtures that were commonplace in dermatological therapy and still persist to this day in commercial products. It is to be hoped that the result of these research endeavors will be the emergence of more innovative topical formulations, applying engineered bioavailability control systems, with broader applications in topical therapeutic and cosmetic vehicles.

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Paul Gerson Unna

Cited by 4 publications

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Paul Gerson Unna (1850–1929) – Genius of all times

Paul Gerson Unna (1850–1929) – Genius of all times

Bibliographic landmarks in the history of dermatology

The Mystical Effects of Dermatological Vehicles

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