Open-graded friction course (OGFC) is recognized for its ability for rapid stormwater drainage and effective noise reduction. Yet, several state highway agencies have limited its use because of concerns about its durability. The objective of this study was to investigate the impacts of air void (AV) reduction, crumb rubber (CR), and pozzolanic fillers on OGFC durability. Six mixtures were fabricated in the laboratory and their performance was evaluated. A control mix, 9.5-NMAS mix, two mixes incorporating CR, and two mixes prepared with pozzolanic fillers (i.e., Portland cement and fly ash) were evaluated. The test factorial was designed so that each mix would be evaluated at three different stages (i.e., production, construction, and field performance). A suite of laboratory tests was conducted including draindown, prediction of compaction effort, Cantabro abrasion loss, Hamburg wheel-tracking, Texas overlay tester, modified Lottman test, and boiling test to evaluate production, compaction, and OGFC resistance to raveling, permanent deformation, cracking, and moisture damage. Results showed that the reduction in AV and the use of CR and pozzolanic fillers considerably enhanced OGFC durability while maintaining appropriate functional performance (i.e., permeability).