Paving Plant‐Food‐Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder

Cruz‐Martins, Natália; Quispe, Cristina; Kırkın, Celale; Şenol, Ezgi; Zuluğ, Aslı; Özçelik, Beraat; Ademiluyi, Adedayo O.; Oyeniran, Olubukola H.; Semwal, Prabhakar; Kumar, Manoj; Sharopov, Farukh; López, Víctor; Les, Francisco; Bagiu, Iulia Cristina; Butnariu, Monica; Sharifi‐Rad, Javad; Alshehri, Mohammed M.; Cho, William C.

doi:10.1155/2021/1131280

Cited by 7 publications

(4 citation statements)

References 186 publications

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“…Piperine, an alkaloid obtained from Piper longum L. and Piper nigrum L. (black pepper), possesses anxiolytic, neuroprotective, and cognition-enhancing effects [ 36 ]. Investigations conducted by Pragnya et al have revealed improved motor deficits in ASD murine models.…”

Section: Phytoconstituents In Asdmentioning

confidence: 99%

“…Traditional medicine has been commonly used in the treatment of ASD. Plant bioactive constituents with neuroprotective actions have therapeutic potential in the treatment of neuropsychological disorders [ 35 , 36 ]. This review discusses the amassing literatures on ASD, predominantly focusing on the dysregulation of PI3K/Akt/mTOR signaling cascade as well as the genetic alteration of the pathway components in the development of ASD.…”

Section: Introductionmentioning

confidence: 99%

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mTOR Signaling Disruption and Its Association with the Development of Autism Spectrum Disorder

et al. 2023

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Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by impairments in social interaction and communication along with repetitive stereotypic behaviors. Currently, there are no specific biomarkers for diagnostic screening or treatments available for autistic patients. Numerous genetic disorders are associated with high prevalence of ASD, including tuberous sclerosis complex, phosphatase and tensin homolog, and fragile X syndrome. Preclinical investigations in animal models of these diseases have revealed irregularities in the PI3K/Akt/mTOR signaling pathway as well as ASD-related behavioral defects. Reversal of the downstream molecular irregularities, associated with mTOR hyperactivation, improved the behavioral deficits observed in the preclinical investigations. Plant bioactive molecules have shown beneficial pre-clinical evidence in ASD treatment by modulating the PI3K/Akt/mTOR pathway. In this review, we summarize the involvement of the PI3K/Akt/mTOR pathway as well as the genetic alterations of the pathway components and its critical impact on the development of the autism spectrum disorder. Mutations in negative regulators of mTORC1, such as TSC1, TSC2, and PTEN, result in ASD-like phenotypes through the disruption of the mTORC1-mediated signaling. We further discuss the various naturally occurring phytoconstituents that have been identified to be bioactive and modulate the pathway to prevent its disruption and contribute to beneficial therapeutic effects in ASD.

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Section: Phytoconstituents In Asdmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mTOR Signaling Disruption and Its Association with the Development of Autism Spectrum Disorder

et al. 2023

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“…So, it not surprising that several studies found a connection between dietary deficiencies and ASD, as a consequence. To help ASD individuals, several plant-based bioactive compounds have been studied as a complement to ASD therapy [ 42 , 43 ].…”

Section: Bioactive Compounds From Plants As Antioxidant Anti-inflamma...mentioning

confidence: 99%

From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain Disorders

2023

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The brain′s sensitivity to oxidative stress and neuronal cell death requires effective pharmacotherapy approaches. Current pharmacological therapies are frequently ineffective and display negative side effects. Bioactive chemicals found in plants may provide a potential alternative due to their antioxidant and neuroprotective properties and can be used in therapy and the management of a variety of neuropsychiatric, neurodevelopmental, and neurodegenerative illnesses. Several natural products, including vitamin C, Cammelia sinensis polyphenols, Hypericum perforatum, and Crocus sativus have shown promise in lowering oxidative stress and treating symptoms of major depressive disorder (MDD). Similarly, bioactive compounds such as curcumin, luteolin, resveratrol, quercetin, and plants like Acorus gramineus, Rhodiola rosea, and Ginkgo biloba are associated with neuroprotective effects and symptom improvement in neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). Furthermore, in neurodegenerative diseases, natural compounds from Rhodiola rosea, Morinda lucida, and Glutinous rehmannia provide neurological improvement. Further study in clinical samples is required to thoroughly investigate the therapeutic advantages of these bioactive substances for persons suffering from these illnesses.

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“…It has been suggested that gut microbiota imbalance and intestinal brain dysfunction, is more prevalent in ASD which seems to be modified by both foods and food products such as probiotics, herbal or natural ingredients including honeybee [8]. The purpose of this ingredients which can be used in industry or added to food products is modification immune system function, nervous system and endocrine system both directly or indirectly [9].…”

Section: Issn: 2577-4182mentioning

confidence: 99%

How Food Industry can help Individuals with Autism Spectrum Disorder and Healthcare System-An opinion

Moiniafshari¹

2022

Madridge J Food Technol.

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This article provides an opinion about how food industry can help individuals with Autism Spectrum Disorder and healthcare system. Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder accompanied by social interaction impairment which is usually accompanied by health-related challenges, especially food and nutritional problems. ASD prevalence has gained a growing trend with in the past years which may increase health care system requirements. It can be suggested that there is a chain between family, healthcare system and food industries which are in relation with each other and can modify ASD symptoms and improve its managements by more cooperation. Healthcare system can put updated knowledge derived from scientific researches into both family and food industries hands in order to improve dietary pattern and provide nutritional requirements in ASD. Food additives modification and/ or food products enrichment with required nutrients may be an effective strategy for ASD. Moreover, food industries may be invited to modify or reduce the artificial additives, as much as possible, or enrich the food products with more organic, bioactive and nutrient dense compounds. Food industries are highly recommended to inform public about the consumed ingredients via appropriate food labels.

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Paving Plant‐Food‐Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder

Cited by 7 publications

References 186 publications

mTOR Signaling Disruption and Its Association with the Development of Autism Spectrum Disorder

mTOR Signaling Disruption and Its Association with the Development of Autism Spectrum Disorder

From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain Disorders

How Food Industry can help Individuals with Autism Spectrum Disorder and Healthcare System-An opinion

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