Pax6 regulates the epidermal growth factor-responsive neural stem cells of the subventricular zone

Jia, Haitao; Hong, Tao; Feng, Ruopeng; Li, Meiyu; Bai, Jie; Sun, Tao; Wen, Jinhua; Hu, Qikuan

doi:10.1097/wnr.0b013e3283476b46

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…Pax-6 reduces the EGFR expression in neural stem cells (Jia et al, 2011) and represses the expression of Olig-2 cells and glial lineage (Jang and Goldman, 2011). Thus, Pax-6 induces neuronal differentiation in embryonic and adult neural precursor cells (Kohwi et al, 2005; Osumi et al, 2008) and determines the neuronal cell fate while decreasing the expression of NG2 (Klempin et al, 2011).…”

Section: Erbb Effects In the Oligodendrocyte Specification In Adult Nmentioning

confidence: 99%

The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the adult mammalian brain

Galvez‐Contreras

Quiñones‐Hinojosa

González-Pérez

2013

Front. Cell. Neurosci.

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In the adult brain, multipotent progenitor cells have been identified in three areas: the ventricular-subventricular zone (VZ-SVZ), adjacent to the striatal wall of the lateral ventricles, the subgranular zone (SGZ), located at the dentate gyrus of the hippocampus and the subcallosal zone (SCZ), located between the corpus callosum and the CA1 and CA2 regions of the hippocampus. The neural progenitor cells of these regions express the epidermal growth factor receptor (EGFR, ErbB-1 or HER1). EGF, the most important ligand for the EGFR, is a potent mitogenic agent that stimulates proliferation, survival, migration and differentiation into the oligodendrocyte lineage. Other ErbB receptors also activate several intracellular pathways for oligodendrocyte specification, migration and survival. However, the specific downstream pathways related to oligodendrogenesis and the hierarchic interaction among intracellular signaling cascades is not well-known. We summarize the current data regarding the role of EGFR and ErbB family signaling on neural stem cells and the downstream cascades involved in oligodendrogenesis in the neurogenic niches of the adult brain. Understanding the mechanisms that regulate proliferation, differentiation, migration of oligodendrocytes and myelination is of critical importance for the field of neurobiology and constitutes a crucial step in the design of stem-cell-based therapies for demyelinating diseases.

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Section: Erbb Effects In the Oligodendrocyte Specification In Adult Nmentioning

confidence: 99%

The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the adult mammalian brain

Galvez‐Contreras

Quiñones‐Hinojosa

González-Pérez

2013

Front. Cell. Neurosci.

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“…Nonetheless, the latter undergo a developmental program supressing Pax6 activity and expressing Tbr2, Svet 1 and other factors ( Englund et al, 2005 ; Sansom et al, 2009 ). Although it is suppressed in intermediate progenitors, Pax6 is a critical promotor of intermediate progenitor production, as its mutation or downregulation produces deficits in the intermediate progenitors, while its overexpression results in a substantial increase and self-renewal of these elements ( Warren et al, 1999 ; Tarabykin et al, 2001 ; Nieto et al, 2004 ; Quinn et al, 2007 ; Pontious et al, 2008 ; Wen et al, 2008 ; Sansom et al, 2009 ; Jia et al, 2011 ). Thus, Pax6 is required for the development of some relatively early, layer V phenotypes (like those expressing Er81; Tuoc and Stoykova, 2008 ), but in later development it facilitates the production of intermediate progenitors in the SVZ, and promotes the differentiation of late born superficial neocortical layers.…”

Section: A Unifying Hypothesismentioning

confidence: 99%

Neural progenitors, patterning and ecology in neocortical origins

Aboitiz

Zamorano

2013

Front. Neuroanat.

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The anatomical organization of the mammalian neocortex stands out among vertebrates for its laminar and columnar arrangement, featuring vertically oriented, excitatory pyramidal neurons. The evolutionary origin of this structure is discussed here in relation to the brain organization of other amniotes, i.e., the sauropsids (reptiles and birds). Specifically, we address the developmental modifications that had to take place to generate the neocortex, and to what extent these modifications were shared by other amniote lineages or can be considered unique to mammals. In this article, we propose a hypothesis that combines the control of proliferation in neural progenitor pools with the specification of regional morphogenetic gradients, yielding different anatomical results by virtue of the differential modulation of these processes in each lineage. Thus, there is a highly conserved genetic and developmental battery that becomes modulated in different directions according to specific selective pressures. In the case of early mammals, ecological conditions like nocturnal habits and reproductive strategies are considered to have played a key role in the selection of the particular brain patterning mechanisms that led to the origin of the neocortex.

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“…Moreover, Pax6 is also induced in regulation of EGF‐induced proliferation of SVZ‐derived NSC. Expression of EGFR in neurospheres from Pax6 mutant mice (E18.5), was down‐regulated in vitro and in vivo, as determined by flow cytometry (93). EGFR has also been associated with the maintenance of multipotency.…”

Section: Introductionmentioning

confidence: 99%

Functions of neurotrophins and growth factors in neurogenesis and brain repair

et al. 2012

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The identification and isolation of multipotent neural stem and progenitor cells in the brain, giving rise to neurons, astrocytes, and oligodendrocytes initiated many studies in order to understand basic mechanisms of endogenous neurogenesis and repair mechanisms of the nervous system and to develop novel therapeutic strategies for cellular regeneration therapies in brain disease. A previous review (Trujillo et al., Cytometry A 2009;75:38-53) focused on the importance of extrinsic factors, especially neurotransmitters, for directing migration and neurogenesis in the developing and adult brain. Here, we extend our review discussing the effects of the principal growth and neurotrophic factors as well as their intracellular signal transduction on neurogenesis, fate determination and neuroprotective mechanisms. Many of these mechanisms have been elucidated by in vitro studies for which neural stem cells were isolated, grown as neurospheres, induced to neural differentiation under desired experimental conditions, and analyzed for embryonic, progenitor, and neural marker expression by flow and imaging cytometry techniques. The better understanding of neural stem cells proliferation and differentiation is crucial for any therapeutic intervention aiming at neural stem cell transplantation and recruitment of endogenous repair mechanisms. ' 2012 International Society for Advancement of Cytometry

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Pax6 regulates the epidermal growth factor-responsive neural stem cells of the subventricular zone

Cited by 6 publications

References 12 publications

The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the adult mammalian brain

The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the adult mammalian brain

Neural progenitors, patterning and ecology in neocortical origins

Functions of neurotrophins and growth factors in neurogenesis and brain repair

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