Paying Attention to the Cortical Layers

Self, Matthew W.; Roelfsema, Pieter R.

doi:10.1016/j.neuron.2016.12.032

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…At this spatial resolution, it becomes possible to measure both anatomical and functional cortical depth-dependent signals that reflect contributions of different cortical layers. Sub-millimeter (laminar) functional MRI (fMRI) promises to complement anatomical measurements across cortical depth with functional properties that may indicate feed-forward and feedback processes 9,10 .…”

Section: Linear Systems Analysis For Laminar Fmri: Evaluating Bold Ammentioning

confidence: 99%

Linear systems analysis for laminar fMRI: Evaluating BOLD amplitude scaling for luminance contrast manipulations

Dijk

Fracasso

Petridou

et al. 2020

Sci Rep

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Linear amplitude scaling generalizes across sessions. Next, we assessed whether these results generalized between sessions. In the second session, participants had to detect when the motion direction of the stimulus was identical on two consecutive presentations. The average discriminability (d') was 2.2, indicating a detection performance of well above chance level (d' of S1-5 were 2.6, 2.2, 2.1, 2.3, and 1.8 respectively, minimum d' for any individual run is 1.4).

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Section: Linear Systems Analysis For Laminar Fmri: Evaluating Bold Ammentioning

confidence: 99%

Linear systems analysis for laminar fMRI: Evaluating BOLD amplitude scaling for luminance contrast manipulations

Dijk

Fracasso

Petridou

et al. 2020

Sci Rep

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“…However, it should be noted that multiple phosphene patterns may not automatically group into perceptually intelligible objects (Stingl et al, 2015; Shivdasani et al, 2017; Christie et al, 2022). This “binding problem” (Roelfsema, 2023) also extends to cortical implants. Although a recent study with intracortical electrodes (Chen et al, 2020) showed that macaques could successfully identify the intended shape of a patterned electrical stimulus, human participants implanted with the same technology could not always do that (Fernández et al, 2021).…”

Section: Discussionmentioning

confidence: 93%

Axonal stimulation affects the linear summation of single-point perception in three Argus II users

Hou

Nanduri

Granley

et al. 2023

Preprint

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Purpose.Retinal implants use electrical stimulation to elicit flashes of light (“phosphenes”). Single-electrode phosphene shape has been shown to vary systematically with stimulus amplitude and frequency as well as the retinal location of the stimulating electrode, due to incidental activation of passing nerve fiber bundles. However, this knowledge has yet to be extended to paired-electrode stimulation.Methods.We retrospectively analyzed 4402 phosphene drawings made by three blind subjects implanted with an Argus II Retinal Prosthesis. Phosphene shape (characterized by area, perimeter, major and minor axis length; normalized per subject) and number of perceived phosphenes were averaged across trials and correlated with the corresponding single-electrode parameters. In addition, the number of phosphenes was correlated with stimulus amplitude and neuroanatomical parameters: electrode-retina (“height”) and electrode-fovea distance (“eccentricity”) as well as the electrode-electrode distance to (“between-axon”) and along axon bundles (“along- axon”). Statistical analyses were conducted using linear regression and partial correlation analysis.Results.Simple regression revealed that each paired-electrode shape descriptor could be predicted by the sum of the two corresponding single- electrode shape descriptors (p < .001). Multiple regression revealed that paired- electrode phosphene shape was primarily predicted by stimulus amplitude, electrode- retina distance, and electrode-fovea distance (p < .05). Interestingly, the number of elicited phosphenes increased with between-axon distance (β= .162, p < .05), but not with along-axon distance (p > .05).Conclusions.The shape of phosphenes elicited by paired-electrode stimulation was well predicted by the shape of their corresponding single-electrode phosphenes, suggesting that two-point perception can be expressed as the linear summation of single-point perception. We also found that the number of perceived phosphenes increased with the between-axon distance of the two electrodes, providing further evidence in support of the axon map model for epiretinal stimulation. These findings contribute to the growing literature on phosphene perception and have important implications for the design of future retinal prostheses.

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“…We use ultra-high field functional magnetic resonance imaging (fMRI) to investigate whether processing of numerosity across cortical depth in parietal cortex fits the canonical cortical microcircuit hypothesis. Ultra-high field MRI allows us to measure both anatomical and functional cortical depth-dependent signals that reflect information processing across cortical depth (for reviews, see De Martino et al, 12 Lawrence et al, 13 Stephan et al, 14 Self et al, 17 Petridou and Siero, 32 and Self and Roelfsema 33 ).…”

Section: Resultsmentioning

confidence: 99%

Laminar processing of numerosity supports a canonical cortical microcircuit in human parietal cortex

et al. 2021

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Paying Attention to the Cortical Layers

Cited by 6 publications

References 10 publications

Linear systems analysis for laminar fMRI: Evaluating BOLD amplitude scaling for luminance contrast manipulations

Linear systems analysis for laminar fMRI: Evaluating BOLD amplitude scaling for luminance contrast manipulations

Axonal stimulation affects the linear summation of single-point perception in three Argus II users

Laminar processing of numerosity supports a canonical cortical microcircuit in human parietal cortex

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