PB@PDA@Ag nanosystem for synergistically eradicating MRSA and accelerating diabetic wound healing assisted with laser irradiation

Tong, Chunyi; Zhong, Xianghua; Yang, Yong; Liu, Xu; Zhong, Guowei; Xiao, Chang; Liu, Bin; Wang, Wei; Yang, Xiaoping

doi:10.1016/j.biomaterials.2020.119936

Cited by 188 publications

(129 citation statements)

References 45 publications

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“…149 Tong et al constructed a combinational antibacterial system by loading AgNPs on the polydopamine-modified prussian blue NPs(PB@PDA@Ag), the bactericidal mechanism of this system can be attributed by damaging cell integrity, producing ROS, the reducing ATP and disrupting bacterial metabolism. 150 Likewise, Zhao et al used polydopamine decorated silver nanoparticles, and then loaded into conductive hydrogel to inhibit bacterial growth and control diabetic wound infection. 151 Gold NPs (AuNPs) can perform gene transfer, drug delivery, as biosensors and cancer cell imaging, angiogenesis as well as wound healing.…”

Section: Non-bioactive Elements Metal Ionmentioning

confidence: 99%

“…15 Tong et al promoted diabetic wound healing through the antibacterial of silver ions. 150 Copper ions can also stimulate angiogenesis and collagen deposition processes in addition to antibacterial effects, thus improving diabetic wound healing. [159][160][161] Rubidium (Rb) is an important microelement for the human body.…”

Section: Metallic and Metal Oxide Nanomaterialsmentioning

confidence: 99%

“…213,252 PB@PDA@Ag NPs can accelerate the healing of diabetic wounds under NIR. 150 In addition, MoS 2 -BNN6 can effectively inhibit the growth of ampicillin-resistant Escherichia coli, heat-resistant Escherichia faecalis, and pathogen Staphylococcus aureus. 212 Although nanoparticles based PTT has great potential for treating diabetic wound infections, local heat can also severely damage surrounding healthy tissue, so precise research and specific clinical trials are needed for PTT therapy.…”

Section: Other Technologymentioning

confidence: 99%

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<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

Bai¹,

Han²,

Dong³

et al. 2020

IJN

159

114

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Diabetic wound shows delayed and incomplete healing processes, which in turn exposes patients to an environment with a high risk of infection. This article has summarized current developments of nanoparticles/hydrogels and nanotechnology used for promoting the wound healing process in either diabetic animal models or patients with diabetes mellitus. These nanoparticles/hydrogels promote diabetic wound healing by loading bioactive molecules (such as growth factors, genes, proteins/peptides, stem cells/exosomes, etc.) and nonbioactive substances (metal ions, oxygen, nitric oxide, etc.). Among them, smart hydrogels (a very promising method for loading many types of bioactive components) are currently favored by researchers. In addition, nanoparticles/hydrogels can be combined with some technology (including PTT, LBL self-assembly technique and 3D-printing technology) to treat diabetic wound repair. By reviewing the recent literatures, we also proposed new strategies for improving multifunctional treatment of diabetic wounds in the future.

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Section: Non-bioactive Elements Metal Ionmentioning

confidence: 99%

Section: Metallic and Metal Oxide Nanomaterialsmentioning

confidence: 99%

Section: Other Technologymentioning

confidence: 99%

See 1 more Smart Citation

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

Bai¹,

Han²,

Dong³

et al. 2020

IJN

159

114

View full text Add to dashboard Cite

show abstract

“…OP, with low methylation (17–25%) and high acetylation (20–40%), 53 has immunoregulatory activity in vivo and can inhibit inflammatory mediators in cells, 54 and also has an anti‐ulcer effect on acute gastric mucosal damage caused by ethanol in vivo 55 . It was observed that by reducing the local inflammatory response and upregulating the expression of vascular endothelial growth factor on the wound bed, the wound healing of diabetes infection was effectively promoted 56 . It has also been reported that driving the cytokine environment and regulating the local inflammatory response in an NF‐κB dependent manner may have a potential impact on tumor immunity and inflammation 57 .…”

Section: Discussionmentioning

confidence: 99%

Okra pectin relieves inflammatory response and protects damaged intestinal barrier in caerulein‐induced acute pancreatic model

Xiong

Zhang

et al. 2020

J Sci Food Agric

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BACKGROUNDProtecting the intestinal mucosa from being destroyed helps reduce the inflammation caused by acute pancreatitis (AP). In this study, whether okra pectin (OP) could attenuate the inflammation of AP through protecting the intestinal barrier was investigated.RESULTSOP was obtained from crude okra pectin (COP) through the purification by DEAE cellulose 52 column. Supplementation with OP or COP in advance reduced the severity of AP, as revealed by lower serum amylase and lipase levels, abated pancreatic edema, attenuated myeloperoxidase activity and pancreas histology. OP or COP inhibited the production of pancreatic proinflammatory cytokines, including tumor necrosis factor‐α and interleukin‐6. In addition, the upregulation of AP‐related proteins including ZO‐1, occludin, the antibacterial peptide‐defensin‐1 (DEFB1) and cathelicidin‐related antimicrobial peptide (CRAMP), as well as the histological examination of colon injuries, demonstrated that OP or COP provision could effectively maintain intestinal barrier function. Ultimately, dietary OP or COP supplementation could inhibit AP‐induced intestinal inflammation. For the above, the effect of OP was better than COP.CONCLUSIONDietary OP supplementation could be considered as a preventive method that effectively interferes with intestinal damage and attenuates inflammatory responses trigged by AP. © 2020 Society of Chemical Industry

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“…[227] Based on the above strategies, Tong et al successfully prepared PB@PDA@Ag NPs as a multifunctional antibacterial agent for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection. [228] First, PB@PDA NPs were engineered by coating the Prussian blue (PB) NP surface with polydopamine (PDA) via musselinspired chemistry. Then, AgNPs were synthesized in situ on the surface of PDA.…”

Section: Nanocatalystsmentioning

confidence: 99%

Which is Better for Nanomedicines: Nanocatalysts or Single‐Atom Catalysts?

Zhao

Zhang

Yang

et al. 2020

Adv Healthcare Materials

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With the rapid advancements in nanotechnology and materials science, numerous nanomaterials have been used as catalysts for nanomedical applications. Their design and modification according to the microenvironment of diseases have been shown to achieve effective treatment. Chemists are in pursuit of nanocatalysts that are more efficient, controllable, and less toxic by developing innovative synthetic technologies and improving existing ones. Recently, single-atom catalysts (SACs) with excellent catalytic activity and high selectivity have attracted increasing attention because of their accurate design as nanomaterials at the atomic level, thereby highlighting their potential for nanomedical applications. In this review, the recent advances in nanocatalysts and SACs are briefly summarized according to their synthesis, characterizations, catalytic mechanisms, and nanomedical applications. The opportunities and future scope for their development and the issues and challenges for their application as nanomedicine are also discussed. As far as it is known, the review is the systematic comparison of nanocatalysts and SACs, especially in the field of nanomedicine, which has promoted the development of nanocatalytic medicine.

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PB@PDA@Ag nanosystem for synergistically eradicating MRSA and accelerating diabetic wound healing assisted with laser irradiation

Cited by 188 publications

References 45 publications

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

Okra pectin relieves inflammatory response and protects damaged intestinal barrier in caerulein‐induced acute pancreatic model

Which is Better for Nanomedicines: Nanocatalysts or Single‐Atom Catalysts?

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