Pb Toxicity on Gut Physiology and Microbiota

Liu, Wenya; Feng, Hai; Zheng, Shuilin; Xu, Shan; Massey, Isaac Yaw; Zhang, Chengcheng; Wang, Xiaoyan; Yang, Fei

doi:10.3389/fphys.2021.574913

Cited by 33 publications

(23 citation statements)

References 117 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pb exposure was also accompanied by disrupted intestinal structure and altered immune status [143]. These and other studies confirm the negative impact of Pb exposure on GM where reduction in beneficial bacteria such as Faecalibacterium and Bifidobacteria, and increase in potentially harmful bacteria like Bacteroides, are observed [144].…”

Section: Pb -Microbiota -Asdsupporting

confidence: 71%

Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder

Tizabi¹,

Bennani²,

Kouhen³

et al. 2023

Preprint

View full text Add to dashboard Cite

Autism Spectrum Disorder (ASD), a neurodevelopmental disorder characterized by persistent deficits in social interaction and social communication manifests in early childhood and is followed by significant impairment in social and occupational functions in adolescence and adulthood. Although genetics have been implicated, the exact causes of ASD have yet to be fully characterized. New evidence suggests that dysbiosis or perturbation in gut microbiota (GM) and exposure to lead (Pb) may play important roles in ASD etiology. Pb is a toxic heavy metal that has been linked to a wide range of negative health outcomes including anemia, encephalopathy, gastroenteric diseases and more importantly cognitive and behavioral problems inherent to ASD. Pb exposure can disrupt GM, which is essential for maintaining overall health. GM, consisting of trillions of microorganisms, has been shown to play a crucial role in the development of various physiological and psychological functions. GM interacts with the brain in a bidirectional manner referred to as “Gut-Brain Axis (GBA).” In this review, following a general overview of ASD and GM, the interaction of Pb with GM in the context of ASD is emphasized. Potential exploitation of this interaction for therapeutic purposes is also touched upon.

show abstract

Section: Pb -Microbiota -Asdsupporting

confidence: 71%

Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder

Tizabi¹,

Bennani²,

Kouhen³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…But recent findings suggest that the microimmunosome may provide a better vantage point for accessing health risks and treatment options. In a review, Liu et al [ 224 ] reported that Pb exposure affects all elements comprising the microimmunosome. It produces dysbiosis of gut microbiota, impairs the gut barrier and increases permeability.…”

Section: Revisiting the Microimmunosome: Bidirectional Approaches For Homeostasismentioning

confidence: 99%

Microbiome First Medicine in Health and Safety

Dietert

2021

Biomedicines

View full text Add to dashboard Cite

Microbiome First Medicine is a suggested 21st century healthcare paradigm that prioritizes the entire human, the human superorganism, beginning with the microbiome. To date, much of medicine has protected and treated patients as if they were a single species. This has resulted in unintended damage to the microbiome and an epidemic of chronic disorders [e.g., noncommunicable diseases and conditions (NCDs)]. Along with NCDs came loss of colonization resistance, increased susceptibility to infectious diseases, and increasing multimorbidity and polypharmacy over the life course. To move toward sustainable healthcare, the human microbiome needs to be front and center. This paper presents microbiome-human physiology from the view of systems biology regulation. It also details the ongoing NCD epidemic including the role of existing drugs and other factors that damage the human microbiome. Examples are provided for two entryway NCDs, asthma and obesity, regarding their extensive network of comorbid NCDs. Finally, the challenges of ensuring safety for the microbiome are detailed. Under Microbiome-First Medicine and considering the importance of keystone bacteria and critical windows of development, changes in even a few microbiota-prioritized medical decisions could make a significant difference in health across the life course.

show abstract

“…For example, it can cause aggressive behavior, anxiety, and depression, and affect learning and cognition ( 6 ). It has also been reported that the intestine is a vital organ for Pb absorption, and that Pb can cause significant intestinal damage ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus casei SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion

et al. 2022

View full text Add to dashboard Cite

Pb poisoning affects infant growth and development. However, dimercaptosuccinic acid (DMSA) as the current therapy for Pb poisoning exerts relatively significant toxic side effects in infants. Therefore, identifying a non-toxic treatment in this regard is particularly important. In this study, we aimed to investigate the therapeutic effect of an infant feces-derived probiotic strain, Lactobacillus casei SYF-08 (SYF-08), on Pb poisoning in young mice. The Pb levels in the organisms were detected via inductively coupled plasma mass spectrometry, while the therapeutic effect of SYF-08 on Pb-induced neural system damage was explored via the Morris water maze test, hematoxylin-eosin staining, and immunohistochemistry. Additionally, the molecular mechanisms underlying the protective effects of SYF-08 against Pb-induced intestinal damage were also explored via histological staining, 16S rRNA sequencing, untargeted metabolomics, qRT-PCR, and western blotting. In vivo experiments revealed that SYF-08 reduced blood and bone Pb levels and increased urinary Pb excretion. Additionally, SYF-08 alleviated Pb-induced pathological damage to the brain and ultimately improved the learning and cognitive abilities of the young mice. This treatment also restored intestinal microflora dysbiosis, regulated bile acid metabolism, and inhibited the FXR-NLRP3 signaling pathway. It also resulted in fewer adverse events than the DMSA treatment. In conclusion, our results provided valuable insights into the therapeutic role of SYF-08 in Pb poisoning and also suggested that its administration can significantly alleviate the Pb-induced damage.

show abstract

Pb Toxicity on Gut Physiology and Microbiota

Cited by 33 publications

References 117 publications

Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder

Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder

Microbiome First Medicine in Health and Safety

Lactobacillus casei SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion

Contact Info

Product

Resources

About