Abstract:Azacytidine and/or decitabine (DAC) were dramatically improved the prognosis of MDS and AML. Whereas, these drugs can be administered intravenously or subcutaneously, therefore the patients must visit a hospital every day. Aims: OR21 is a novel and potentially oral absorbable DAC prodrug. Actually, direct duodenal administration of OR21 successfully absorbed in cynomolgus monkey model. In this study, we investigated the efficacy of OR21 in MDS (MDS-L), AML cell lines (HL60, THP1, KG1a, Kasumi-1). Methods: OR21… Show more
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