Pb1797: Zno Nanoparticles Promotes Human Acute Myeloid Leukemia (Thp-1) Cell Apoptosis Based on Mitochondrial Fission Pathway

Abstract

Background:Background: AML is a malignant tumor caused by changes in myeloid hematopoietic stem cells and abnormal changes in the proportion of primitive and immature myeloid cells. ZnO NPs have unique optical, chemical, electrical conductivity, antibacterial and anti-tumor properties, and are widely used in antibacterial, wound healing and tumor treatment. Mitochondria are a highly dynamic organelle that is important for many biological processes. At present, the effect of ZnO NPs on mitochondrial division and on human THP-1 cell apoptosis is still unclear. Aims:Aims: The present study aimed to elucidate the underlying mechanism of ZnO NPs induced apoptosis in acute myeloid leukemia (AML) cells by regulating mitochondrial division. Methods:Methods: The inhibitory effect of ZnO NPs on THP-1 cell proliferation was monitored by the CCK-8 method, and the