Pb1835: Shengma Biejia Decoction,a Traditional Chinese Medicine Prescription,induces Leukemia Cells Mitochondrial Autophagy via Mitochondrial Division Way.

Abstract

Background:Acute leukemia(AL) is a modern disease, but there are records about this kind of diseases in the classical Chinese medicine books thousands of years ago. The description of yin and yang toxicosis in the classic Chinese medicine book "Jingui Yaolue" conforms to the clinical manifestations of acute leukemia. Its prescription for treating yin and yang toxicosis is Shengma Biejia Decoction. The formula contains realgar(As4S4), an important drug for the treatment of acute promyelocytic leukemia. In China, Shengma Biejia Decoction has been frequently used in the treatment of acute leukemia and has achieved excellent clinical efficacy. However, its mechanism of action is not fully clear.