PBAT/gelatin hybrid nanofibers based on post-double network bond processing as a promising vascular substitute

Nie, Jiakun; Jin, Changjie; Liu, Yonghang; Du, Juan; Chen, Sihao; Yang, Zheng; Lou, Binbin

doi:10.1039/d2ra02313j

RSC Adv.

2022

DOI: 10.1039/d2ra02313j

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PBAT/gelatin hybrid nanofibers based on post-double network bond processing as a promising vascular substitute

Jiakun Nie

Changjie Jin

Yonghang Liu

et al.

Abstract: A PBAT/gelatin hybrid nanofibers vascular graft containing 15 wt% gelation (P/G-15) exhibited matched mechanical properties, especially they demonstrate excellent blood compatibility, cellular compatibility, and histocompatibility in rabbit carotid artery model.

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Cited by 5 publications

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Versatile cell cultivation on injectable poly(butylene adipate‐co‐terephthalate) microcarriers: Impact of surface properties across different cell types

Koç,

Gümüşderelioğlu

2024

J Biomed Mater Res

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Injectable cell therapies offer several advantages compared with traditional open surgery, including less trauma to the patient, shorter recovery time, and lower risk of infection. However, a significant problem is the difficulty in developing effective cell delivery carriers that are cyto‐compatible and maintain cell viability both during and after injection. In the presented study, it was aimed to develop poly(butylene adipate‐co‐terephthalate) (PBAT) microcarriers using the emulsion preparation‐solvent evaporation technique. The optimized diameter of the PBAT microcarriers was determined as 104 ± 15 μm at 700 rpm and there would be no blockage after injection due to the nonswelling feature of microcarriers. Furthermore, the cellular activities of PBAT microcarriers were evaluated in static culture for 7 days using L929 mouse fibroblasts, MC3T3‐E1 mouse pre‐osteoblasts, and rat adipose‐derived mesenchymal cells (AdMSCs). 3‐[4,5‐Dimethylthiazol‐2‐yl]‐2,5‐diphenyltetrazolium bromide results and Sscanning electron microscope images showed that PBAT microcarriers increased the adhesion and proliferation properties of pre‐osteoblasts and stem cells, while L929 fibroblasts formed aggregates by adhering to certain regions of the microcarrier surface and did not spread on the surface. These results emphasize that PBAT microcarriers can be used as injectable carriers, especially in stem cell therapies, but their surface properties need to be modified for some cells.

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Versatile cell cultivation on injectable poly(butylene adipate‐co‐terephthalate) microcarriers: Impact of surface properties across different cell types

Koç,

Gümüşderelioğlu

2024

J Biomed Mater Res

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Oriented fibrous poly (butylene adipate-co-terephthalate) matrices with nanotopographic features: Production and characterization

Ilhan

Gümüşderelı́oğlu

2023

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Electrospun membranes of carboxylated poly(ester urethane)urea/gelatin encapsulating pterostilbene for adaptive and antioxidative purposes

Zang

Cheng

Wang

et al. 2022

Journal of Biomaterials Science, Polymer Edition

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PBAT/gelatin hybrid nanofibers based on post-double network bond processing as a promising vascular substitute

Abstract: A PBAT/gelatin hybrid nanofibers vascular graft containing 15 wt% gelation (P/G-15) exhibited matched mechanical properties, especially they demonstrate excellent blood compatibility, cellular compatibility, and histocompatibility in rabbit carotid artery model.

Cited by 5 publications

References 49 publications

Versatile cell cultivation on injectable poly(butylene adipate‐co‐terephthalate) microcarriers: Impact of surface properties across different cell types

Versatile cell cultivation on injectable poly(butylene adipate‐co‐terephthalate) microcarriers: Impact of surface properties across different cell types

Oriented fibrous poly (butylene adipate-co-terephthalate) matrices with nanotopographic features: Production and characterization

Electrospun membranes of carboxylated poly(ester urethane)urea/gelatin encapsulating pterostilbene for adaptive and antioxidative purposes

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