PBK/TOPK Is a Favorable Prognostic Biomarker Correlated with Antitumor Immunity in Colon Cancers

Lee, Dong-Hee; Jeong, Yu Jeong; Won, Jaeyeon; Sim, Hyun Sang; Park, Yoon; Jin, Hyung‐seung

doi:10.3390/biomedicines10020299

Cited by 6 publications

(3 citation statements)

References 66 publications

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“…Additionally, PBK promotes metastasis and resistance to oxaliplatin by regulating pathways such as ETV4-uPAR and PTEN in hepatocellular carcinoma [ 47 , 48 ]. The prognostic value of PBK in prediction of survival and antitumor immunity was also proved in colorectal cancer [ 49 – 51 ]. Therefore, the prognostic CRs identified in our study also exert fundamental role in various cancers and have potential to be reliable survival predictor and therapeutic targets.…”

Section: Discussionmentioning

confidence: 99%

Characterization of molecular subtypes based on chromatin regulators and identification of the role of NPAS2 in lung adenocarcinoma

et al. 2023

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Background Chromatin regulators (CRs) are critical epigenetic modifiers and have been reported to play critical roles during the progression of various tumors, but their role in lung adenocarcinoma (LUAD) has not been comprehensively studied. Methods Differential expression and univariate Cox regression analyses were conducted to identify the prognostic CRs. Consensus clustering was applied to classify the subtypes of LUAD based on prognostic CRs. LASSO-multivariate Cox regression method was used for construction of a prognostic signature and development of chromatin regulator-related gene index (CRGI). The capacity of CRGI to distinguish survival was evaluated via Kaplan–Meier method in multiple datasets. Relationship between CRGI and tumor microenvironment (TME) was evaluated. Additionally, clinical variables and CRGI were incorporated to create a nomogram. The role of the prognostic gene NPAS2 in LUAD was elucidated via clinical samples validation and a series of in vitro and in vivo experiments. Results Two subtypes of LUAD were classified based on 46 prognostic CRs via consensus clustering which had significantly different survival and TME. A prognostic signature consisting of six CRs (MOCS, PBK, CBX3, A1CF, NPAS2, and CTCFL) was developed and proved to be an effective survival predictor in multiple independent datasets. The prognostic signature was also demonstrated to be an indicator of TME and sensitivity to immunotherapy and chemotherapy. The nomogram was suggested to be a simple tool that can predict survival accurately. Clinical samples show that NPAS2 is highly expressed in LUAD tissues, and in vitro and in vivo experiments demonstrated that inhibition of NPAS2 impeded malignant progression of LUAD cells. Conclusions Our study comprehensively unveiled the functions of CRs in LUAD, developed a classifier to predict survival and response to treatments, and suggested that NPAS2 promoted LUAD progression for the first time.

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Section: Discussionmentioning

confidence: 99%

Characterization of molecular subtypes based on chromatin regulators and identification of the role of NPAS2 in lung adenocarcinoma

et al. 2023

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“…The PBK is a novel serine/threonine kinase that is highly expressed in proliferating cells and tissues [ 51 ]. A recent study demonstrated a negative correlation between PBK expression and immune suppressor cells, including regulatory T cells and M2 macrophages [ 52 ]. Moreover, Zhu et al [ 53 ] found that PBK expression was suppressed after the development of inflammation in thin endometrium.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Proteomic Analysis of Zearalenone-Induced Intestinal Damage in Weaned Piglets

Jiang²,

Lü³

et al. 2022

Toxins

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Zearalenone (ZEN), also known as the F-2 toxin, is a common contaminant in cereal crops and livestock products. This experiment aimed to reveal the changes in the proteomics of ZEN-induced intestinal damage in weaned piglets by tandem mass spectrometry tags. Sixteen weaned piglets either received a basal diet or a basal diet supplemented with 3.0 mg/kg ZEN in a 32 d study. The results showed that the serum levels of ZEN, α-zearalenol, and β-zearalenol were increased in weaned piglets exposed to ZEN (p < 0.05). Zearalenone exposure reduced apparent nutrient digestibility, increased intestinal permeability, and caused intestinal damage in weaned piglets. Meanwhile, a total of 174 differential proteins (DEPs) were identified between control and ZEN groups, with 60 up-regulated DEPs and 114 down-regulated DEPs (FC > 1.20 or <0.83, p < 0.05). Gene ontology analysis revealed that DEPs were mainly involved in substance transport and metabolism, gene expression, inflammatory, and oxidative stress. The Kyoto Encyclopedia of Genes and Genomes analysis revealed that DEPs were significantly enriched in 25 signaling pathways (p < 0.05), most of which were related to inflammation and amino acid metabolism. Our study provides valuable clues to elucidate the possible mechanism of ZEN-induced intestinal injury.

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“…found that TOPK could influence the level of immune cell infiltration in colon cancer. 19 Moreover, Tingting Feng et al. found that TOPK was associated with T cell function infiltrating in RCC by bioinformatics, suggesting that TOPK may affect immune evasion in RCC, although the exact mechanism is unknown.…”

Section: Introductionmentioning

confidence: 99%

TOPK mediates immune evasion of renal cell carcinoma via upregulating the expression of PD-L1

Li¹,

Sun²,

Fu³

et al. 2023

iScience

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PBK/TOPK Is a Favorable Prognostic Biomarker Correlated with Antitumor Immunity in Colon Cancers

Cited by 6 publications

References 66 publications

Characterization of molecular subtypes based on chromatin regulators and identification of the role of NPAS2 in lung adenocarcinoma

Characterization of molecular subtypes based on chromatin regulators and identification of the role of NPAS2 in lung adenocarcinoma

Quantitative Proteomic Analysis of Zearalenone-Induced Intestinal Damage in Weaned Piglets

TOPK mediates immune evasion of renal cell carcinoma via upregulating the expression of PD-L1

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