PCB-induced oxidative stress in endothelial cells: modulation by nutrients

Hennig, Bernhard; Hammock, Bruce D.; Slim, Rabih; Toborek, Michał; Saraswathi, Viswanathan; Robertson, Larry W.

doi:10.1078/1438-4639-00134

Cited by 95 publications

(76 citation statements)

References 35 publications

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“…Sergeev and Carpenter (2005), examining rates of hospitalization for cardiovascular disease and acute myocardial infarction in residents living in zip codes containing or abutting hazardous waste sites contaminated with persistent organic pollutants, found statistically significant elevations of cardiovascular disease compared to populations not living near such waste sites. Hennig et al (2002) have demonstrated that dioxin-like PCBs induce oxidative damage of endothelial cells through the generation of reactive oxygen species (Slim et al, 1999). Non-dioxin-like PCBs also induce oxidative stress in endothelial cells, with the induction being mediated via stimulation of inflammatory processes (Choi et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population

Гончаров

Haase

Santiago-Rivera

et al. 2008

Environmental Research

166

110

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We have investigated the relationships among the concentration of total serum polychlorinated biphenyls (PCBs), various PCB congener groupings, and three pesticides to total serum lipids in humans with and without self-reported cardiovascular disease. Blood samples were obtained from 335 adult Akwesasne Mohawks, and were analyzed for 101 PCB congeners, mirex, DDE, and hexachlorobenzene (HCB), as well as serum triglycerides and cholesterol. Structural equation modeling, following the definition of latent variables by means of confirmatory factor analysis, was used to analyze the relationships between serum lipids with PCBs and heart disease. There were significant associations among PCBs, lipids, age, and body mass index (BMI), a fact which justified the application of the structural equation model. Gender of the participant was unrelated to any of the remaining study variables. The results of this study are consistent with a model in which age is considered as both an exogenous explanatory variable and a biological driving mechanism for the acquisition of PCBs. Moreover, the results of this study are consistent with the conclusion that PCBs, acting through P450 enzymes, are directly responsible for increased synthesis of cholesterol and triglycerides, substances known to be major risk factors for cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population

Гончаров

Haase

Santiago-Rivera

et al. 2008

Environmental Research

166

110

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“…Arachidonic acid epoxides (EETs) are endogenous regulators that influence inflammation (Node et al 1999) and blood pressure (Roman 2002) in the kidney. It has been established that sEH inactivates the anti-hypertensive and antiinflammatory effects of EETS (Hennig et al 2002;Imig et al 2002;Schmelzer et al 2005;Imig 2008). Therefore, the impact of sEH inhibition on cisplatin-induced inflammation represents a logical approach to future studies and suggests that these inhibitors may be protective against other number of insults responsible for acute kidney injury, given the role of inflammation in this pathophysiology (Bonventre 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Arachidonic acid epoxides [epoxyeicosatrienoic acids (EETs)] are endogenous regulators that influence inflammation (Node et al 1999) and blood pressure (Roman 2002) in the kidney; both inflammation and renal blood flow are critical mediators of cisplatin-mediated acute kidney injury (Jo et al 2005;Winston and Safirstein 1985). Given that sEH inactivates the antihypertensive and anti-inflammatory effects of EETS (Imig et al 2002;Hennig et al 2002), we hypothesized that a sEH inhibitor, such as the n-butyl ester of 12-(3-adamantan-1-ylureido)-dodecanoic acid (nbAUDA), will attenuate cisplatin-induced nephrotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase

et al. 2008

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Cisplatin is a highly effective chemotherapeutic agent against many tumors; however, it is also a potent nephrotoxicant. Given that there have been no significant advances in our ability to clinically manage acute renal failure since the advent of dialysis, the development of novel strategies to ablate nephrotoxicity would represent a significant development. In this study, we investigated the ability of an inhibitor of soluble epoxide hydrolase (sEH), n-butyl ester of 12-(3-adamantan-1-yl-ureiido)-dodecanoic acid (nbAUDA), to attenuate cisplatin-induced nephrotoxicity. nbAUDA is quickly converted to AUDA and results in maintenance of high AUDA levels in vivo. Subcutaneous administration of 40 mg/kg of nbAUDA to C3H mice every 24 h resulted in elevated blood levels of AUDA; this protocol was also associated with attenuation of nephrotoxicity induced by cisplatin (intraperitoneal injection) as assessed by BUN levels and histological evaluation of kidneys. This is the first report of the use of sEH inhibitors to protect against acute nephrotoxicity and suggests a therapeutic potential of these compounds.

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“…The kinetics of cell surface receptor expression in children perinatally exposed to polychlorinated biphenyls M. Horváthová 1 have reported adverse effects of PCBs on child neurodevelopment, and immune system development (Hennig et al, 2002;Choi et al, 2003;Ulbrich and Stahlmann, 2004;Chevrier et al, 2007;Hertz-Picciotto et al, 2008). Neubert et al (1998) described age-dependent changes in major maturational receptors on CD4 + and CD8 + lymphocytes in different age groups of healthy children (≤ 1, > 1-3, 3-7 years, etc.).…”

Section: Research Articlementioning

confidence: 99%

The kinetics of cell surface receptor expression in children perinatally exposed to polychlorinated biphenyls

Horváthová

Jahnová

Palkovičová

et al. 2011

Journal of Immunotoxicology

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PCB-induced oxidative stress in endothelial cells: modulation by nutrients

Cited by 95 publications

References 35 publications

High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population

High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population

Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase

The kinetics of cell surface receptor expression in children perinatally exposed to polychlorinated biphenyls

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