PCDD/F and PCB concentrations in sera from the Canadian Health Measures Survey (CHMS) from 2007 to 2009

Rawn, Dorothea F. K.; Ryan, John; Sadler, Amy R.; Sun, Wing-Fung; Haines, Douglas; Macey, Kristin; Oostdam, Jay Van

doi:10.1016/j.envint.2012.05.008

Cited by 33 publications

(23 citation statements)

References 33 publications

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“…Levels found in NHANES are in the same range as the Danish results, however, with some of the congeners (PCB-138 and 180) being higher in Denmark and some being higher in NHANES (PCB-52 and 118) [31]. Also the calculated WHO TEQ levels are similar to or lower than what is reported in other studies (table 7) [27,29,[34][35][36]. The measurements of AhR-mediated dioxin-like activity in the participants of the present study are also comparable to previous studies.…”

Section: Ddt Hcb and B-hchcontrasting

confidence: 32%

PCB Concentrations and Dioxin‐like Activity in Blood Samples from Danish School Children and Their Mothers living in Urban and Rural Areas

Mørck

Erdmann

Long

et al. 2014

Basic Clin Pharma Tox

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Human exposure to persistent organic pollutants (POPs) is of major concern due to a diversity of adverse effects from prolonged exposure and bioaccumulation. Manufacturing of polychlorinated biphenyls (PCBs), a subgroup of POPs, has been prohibited for many decades; however, human exposure still occurs due to the persistent nature of the chemicals. The concentrations of the dioxin-like PCB congeners 105, 118 and 156 and the non-dioxin-like PCB congeners 28, 52, 101, 138, 153 and 180, pHCB and b-HCH as well as the dioxin-like activity using the AhR transactivity assay were analysed in blood samples from Danish schoolchildren and their mothers in the European framework of the DEMOCOPHES/COPHES projects. The participants were selected from an urban and a rural area, respectively. The PCB concentrations and the AhR-TEQ (TCDD toxic equivalent) were significantly higher in schoolchildren living in the urban area compared with the rural, and for AhR-TEQ, a strong correlation between the mothers and children was observed. We found a significant negative correlation between BMI and PCB concentrations in the children. Finally, in the mothers, there was a positive association between age and PCB concentration. These results show that both PCBs and dioxin-like activity can be measured as biomarkers of exposure and effects in blood samples from children and women. The results indicate that people living in urban areas may be exposed to higher concentrations of PCBs, dioxins and dioxin-like chemicals, which may lead to a greater risk of adverse effects for urban populations.

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Section: Ddt Hcb and B-hchcontrasting

confidence: 32%

PCB Concentrations and Dioxin‐like Activity in Blood Samples from Danish School Children and Their Mothers living in Urban and Rural Areas

Mørck

Erdmann

Long

et al. 2014

Basic Clin Pharma Tox

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“…In this study, we observed the highest levels of PCB congeners in breast tissue from Groups II and III, which have been associated with breast cancer potential in vitro, but we detected no associations between total PCB levels, functional groupings, or individual congeners and clinical and pathological characteristics in women with breast disease. Although body burdens of PCBs continue to decline due to regulatory measures in many areas (Mannetje et al, 2013), levels of PCBs in humans are strongly associated with age, reflecting long-term environmental exposure and bioaccumulation (Consonni et al, 2012;Paris-Pombo et al, 2003;Rawn et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Abundance and distribution of polychlorinated biphenyls (PCBs) in breast tissue

Ellsworth¹,

Mamula²,

Costantino³

et al. 2015

Environmental Research

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“…However, the levels of POPs in these samples were frequently below the LOD, limiting the usefulness of the data for establishing national averages. 27 In a follow-up study, Rawn et al 28 used a pooling strategy to estimate baseline concentrations of polychlorinated dibenzodioxins/furans and polychlorinated biphenyls for the same population. Leftover serum samples with a typical sample volume of 350 ml were pooled, where 80 individuals contributed to a single pool to ensure sufficient sample volume (B25 ml) was available for analysis and to reduce the number of undetected compounds.…”

Section: Financial Costmentioning

confidence: 99%

Pooled biological specimens for human biomonitoring of environmental chemicals: Opportunities and limitations

Heffernan

Aylward

Toms

et al. 2013

J Expo Sci Environ Epidemiol

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Biomonitoring has become the "gold standard" in assessing chemical exposures, and has an important role in risk assessment. The pooling of biological specimens-combining multiple individual specimens into a single sample-can be used in biomonitoring studies to monitor levels of exposure and identify exposure trends or to identify susceptible populations in a cost-effective manner. Pooled samples provide an estimate of central tendency and may also reveal information about variation within the population. The development of a pooling strategy requires careful consideration of the type and number of samples collected, the number of pools required and the number of specimens to combine per pool in order to maximise the type and robustness of the data. Creative pooling strategies can be used to explore exposure-outcome associations, and extrapolation from other larger studies can be useful in identifying elevated exposures in specific individuals. The use of pooled specimens is advantageous as it saves significantly on analytical costs, may reduce the time and resources required for recruitment and, in certain circumstances, allows quantification of samples approaching the limit of detection. In addition, the use of pooled samples can provide population estimates while avoiding ethical difficulties that may be associated with reporting individual results.

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PCDD/F and PCB concentrations in sera from the Canadian Health Measures Survey (CHMS) from 2007 to 2009

Cited by 33 publications

References 33 publications

PCB Concentrations and Dioxin‐like Activity in Blood Samples from Danish School Children and Their Mothers living in Urban and Rural Areas

PCB Concentrations and Dioxin‐like Activity in Blood Samples from Danish School Children and Their Mothers living in Urban and Rural Areas

Abundance and distribution of polychlorinated biphenyls (PCBs) in breast tissue

Pooled biological specimens for human biomonitoring of environmental chemicals: Opportunities and limitations

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