PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer

Wen, Yu‐Ching; Liu, Chien‐Liang; Yeh, Hsiu-Lien; Chen, Wei-Hao; Jiang, Kuo-Ching; Tram, Van Thi Ngoc; Hsiao, Michael; Huang, Jiaoti; Chen, Wei-Yu; Liu, Yen-Nien

doi:10.1038/s41416-021-01631-3

Cited by 7 publications

(11 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can be seen by combining the specific position of five clusters from Figure 5 that early research around the year 2011, “study of tumor oxidative stress and inflammation signaling pathways and resistance mechanisms of different cancer types (cluster 4 and cluster 2)” had attracted a lot of attention in academia of this field. Afterward, “Study of cancer cell apoptosis pathway (cluster 1)” progressively gained importance around 2014, and some areas remain the hotpots until today, for example, “androgen receptor” (APY = 2018.82) ( 103 ), “glioblastoma” (APY= 2018.54) ( 79 ), and “transcription” (APY= 2018.15) ( 104 ). Notably, cluster 3 and cluster 5 (“study of cancer stem cells and autophagy”) are the two clusters that had the smallest APY compared with other clusters, and “metabolic reprogramming” (APY= 2019.39) ( 105 ), “microRNAs” (APY= 2019.05) ( 106 ) were mainly found lately.…”

Section: Resultsmentioning

confidence: 99%

“…It can be seen by combining the specific position of five clusters from Figure 5 that early research around the year 2011, "study of tumor oxidative stress and inflammation signaling pathways and resistance mechanisms of different cancer types (cluster 4 and cluster 2)" had attracted a lot of attention in academia of this field. Afterward, "Study of cancer cell apoptosis pathway (cluster 1)" progressively gained importance around 2014, and some areas remain the hotpots until today, for example, "androgen receptor" (APY = 2018.82) (103), "glioblastoma" (APY= 2018.54) (79), and "transcription" (APY= 2018.15) (104).…”

Section: The Transition Of Research Focusmentioning

confidence: 99%

See 1 more Smart Citation

Trends in metabolic signaling pathways of tumor drug resistance: A scientometric analysis

et al. 2022

View full text Add to dashboard Cite

BackgroundCancer chemotherapy resistance is one of the most critical obstacles in cancer therapy. Since Warburg O first observed alterations in cancer metabolism in the 1950s, people gradually found tumor metabolism pathways play a fundamental role in regulating the response to chemotherapeutic drugs, and the attempts of targeting tumor energetics have shown promising preclinical outcomes in recent years. This study aimed to summarize the knowledge structure and identify emerging trends and potential hotspots in metabolic signaling pathways of tumor drug resistance research.MethodsPublications related to metabolic signaling pathways of tumor drug resistance published from 1992 to 2022 were retrieved from the Web of Science Core Collection database. The document type was set to articles or reviews with language restriction to English. Two different scientometric software including Citespace and VOS viewer were used to conduct this scientometric analysis.ResultsA total of 2,537 publications including 1,704 articles and 833 reviews were retrieved in the final analysis. The USA made the most contributions to this field. The leading institution was the University of Texas MD Anderson Cancer Center. Avan A was the most productive author, and Hanahan D was the key researcher with the most co-citations, but there is no leader in this field yet. Cancers was the most influential academic journal, and Oncology was the most popular research field. Based on keywords occurrence analysis, these selected keywords could be roughly divided into five main topics: cluster 1 (study of cancer cell apoptosis pathway); cluster 2 (study of resistance mechanisms of different cancer types); cluster 3 (study of cancer stem cells); cluster 4 (study of tumor oxidative stress and inflammation signaling pathways); and cluster 5 (study of autophagy). The keywords burst detection identified several keywords as new research hotspots, including “tumor microenvironment,” “invasion,” and “target”.ConclusionTumor metabolic reprogramming of drug resistance research is advancing rapidly. This study serves as a starting point, providing a thorough overview, the development landscape, and future opportunities in this field.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: The Transition Of Research Focusmentioning

confidence: 99%

Trends in metabolic signaling pathways of tumor drug resistance: A scientometric analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Catecholamines norepinephrine and epinephrine have been demonstrated to play a role in metabolic reprogramming and epithelial-to-mesenchymal transition in liver and colorectal cancers ( 76 , 77 ). PCK1 regulates glucose metabolism and neuroendocrine differentiation through the activation of LIF/ZBTB46 signaling in castration-resistant prostate cancer ( 78 ). Together, these and other numerous studies provide compelling evidence that epinephrine and norepinephrine play an important role in the metabolism of substances and energy, which promotes the growth and spread of tumors in multiple of cancer types ( Figure 4 ).…”

Section: Crosstalk Between Neuroendocrine Regulation and Tumor Cell M...mentioning

confidence: 99%

“…Chronic stressinduced epinephrine promotes the development of breast cancer stem-like traits by rewiring the metabolism in a lactate d e h y d r o g e n as e A ( L D H A ) d e p e n d e n t m a n n e r ( 7 5 ) .Catecholamines norepinephrine and epinephrine have been demonstrated to play a role in metabolic reprogramming and epithelial-to-mesenchymal transition in liver and colorectal cancers(76,77). PCK1 regulates glucose metabolism and neuroendocrine differentiation through the activation of LIF/ ZBTB46 signaling in castration-resistant prostate cancer(78).…”

mentioning

confidence: 99%

Emerging role of substance and energy metabolism associated with neuroendocrine regulation in tumor cells

Liu

Gao

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

Cancer is the second most common cause of mortality in the world. One of the unresolved difficult pathological mechanism issues in malignant tumors is the imbalance of substance and energy metabolism of tumor cells. Cells maintain life through energy metabolism, and normal cells provide energy through mitochondrial oxidative phosphorylation to generate ATP, while tumor cells demonstrate different energy metabolism. Neuroendocrine control is crucial for tumor cells’ consumption of nutrients and energy. As a result, better combinatorial therapeutic approaches will be made possible by knowing the neuroendocrine regulating mechanism of how the neuroendocrine system can fuel cellular metabolism. Here, the basics of metabolic remodeling in tumor cells for nutrients and metabolites are presented, showing how the neuroendocrine system regulates substance and energy metabolic pathways to satisfy tumor cell proliferation and survival requirements. In this context, targeting neuroendocrine regulatory pathways in tumor cell metabolism can beneficially enhance or temper tumor cell metabolism and serve as promising alternatives to available treatments.

show abstract

“…The elevation of PCK1 encouraged the production of neuroendocrine markers that are beneficial for the development of castration-resistant prostate cancer's (CRPC's) neuroendocrine features. Leukemia-inhibitory factor (LIF)/zinc finger LIF signaling activation regulates PCK1 and neuroendocrine marker expression through the BTB domain-containing 46 (ZBTB46) transcription factor [ 92 ]. Hence, when PCK1 is addressed, prostate cancer cells can grow more slowly and display fewer neuroendocrine traits both in vitro and in vivo [ 92 ].…”

Section: Roles Of Pck1 In Cancer Cell Metabolism Proliferation and Me...mentioning

confidence: 99%

Emerging roles of cytosolic phosphoenolpyruvate kinase 1 (PCK1) in cancer

Abate,

Mehdi,

Addisu

et al. 2023

Biochemistry and Biophysics Reports

View full text Add to dashboard Cite

PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer

Cited by 7 publications

References 40 publications

Trends in metabolic signaling pathways of tumor drug resistance: A scientometric analysis

Trends in metabolic signaling pathways of tumor drug resistance: A scientometric analysis

Emerging role of substance and energy metabolism associated with neuroendocrine regulation in tumor cells

Emerging roles of cytosolic phosphoenolpyruvate kinase 1 (PCK1) in cancer

Contact Info

Product

Resources

About