PCL and PCL/bioactive glass biomaterials as carriers for biologically active polyphenolic compounds: Comprehensive physicochemical and biological evaluation

Dziadek, Michał; Dziadek, Kinga; Chęcińska, Kamila; Zagrajczuk, Barbara; Gołda-Cępa, Monika; Brzychczy-Włoch, Monika; Menaszek, E.; Kopeć, Aneta; Cholewa‐Kowalska, Katarzyna

doi:10.1016/j.bioactmat.2020.11.025

Cited by 35 publications

(46 citation statements)

References 73 publications

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“…Antioxidants, by catching the free radical, give away a hydrogen atom or an electron, which is the transfer of a proton, resulting in a stable molecule and radical derived from an antioxidant [54]. Cellular studies conducted by Dziadek et al (2021) using macrophages have shown that the production of reactive oxygen species is lower when cells are cultured in contact with films enriched with polyphenols [37]. Additionally, Dziadek et al (2021) studied antioxidant activity of the materials using ABTS and DPPH free radical scavenging assays and ferric reducing antioxidant power (FRAP) test.…”

Section: Cell Studiesmentioning

confidence: 99%

Polyphenol-Enriched Composite Bone Regeneration Materials: A Systematic Review of In Vitro Studies

Chęcińska

Chęciński²,

Cholewa‐Kowalska

et al. 2022

IJMS

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One of the possible alternatives for creating materials for the regeneration of bone tissue supporting comprehensive reconstruction is the incorporation of active substances whose controlled release will improve this process. This systematic review aimed to identify and synthesize in vitro studies that assess the suitability of polyphenolics as additives to polymer-ceramic composite bone regeneration materials. Data on experimental studies in terms of the difference in mechanical, wettability, cytocompatibility, antioxidant and anti-inflammatory properties of materials were synthesized. The obtained numerical data were compiled and analyzed in search of percentage changes of these parameters. The results of the systematic review were based on data from forty-six studies presented in nineteen articles. The addition of polyphenolic compounds to composite materials for bone regeneration improved the cytocompatibility and increased the activity of early markers of osteoblast differentiation, indicating a high osteoinductive potential of the materials. Polyphenolic compounds incorporated into the materials presumably give them high antioxidant properties and reduce the production of reactive oxygen species in macrophage cells, implying anti-inflammatory activity. The evidence was limited by the number of missing data and the heterogeneity of the data.

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Section: Cell Studiesmentioning

confidence: 99%

Polyphenol-Enriched Composite Bone Regeneration Materials: A Systematic Review of In Vitro Studies

Chęcińska

Chęciński²,

Cholewa‐Kowalska

et al. 2022

IJMS

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“…[25][26][27][28] Polyester with a low glass transition temperature (T g ) and melting temperature is a kind of polymers with good biocompatibility and easy degradability, [29][30][31][32] which is widely used in biomedicine and self-assembly fields. [33][34][35][36] When applied to the field of SPEs, the polyester-based electrolyte possesses a wider electrochemically stable window and higher lithium-ion transference number, [37][38][39][40][41][42] which is a very promising material and is expected to replace PEO-based SPEs. It noted to be pointed out that polyester has a similar thermal property and semi-crystallinity to PEO.…”

Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis of Polyester-Based Linear and Graft Copolymers for Solid Polymer Electrolytes

Guo

Gong

et al. 2022

CCS Chem

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“…One group of beneficial medicinal plants is the genus Salvia , which belongs to the Lamiaceae family and includes approximately 900 species [ 4 ]. It is cultivated throughout the world for use in food industries as spices (to flavor meats such as pork, sausage, and poultry) as well as in cosmetics [ 5 , 6 ], newly formulated biomaterials [ 7 , 8 , 9 ], and active food packaging [ 10 ]. Studies have indicated that several species of sage (including Salvia officinalis L. and Salvia sclarea L.) show biological activities such as antioxidant, antibacterial, antifungal, anticancer, antimutagenic, anti-inflammatory, and antidepressant activities [ 5 , 6 , 11 , 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Changes in Bioactive Compounds and Antioxidant Activity of Chia (Salvia hispanica L.) Herb under Storage and Different Drying Conditions: A Comparison with Other Species of Sage

et al. 2022

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Studies on herb chia (Salvia hispanica L.) are very limited. Therefore, the aim of this study was to assess how different drying methods and periods of storage affect the bioactive properties of the herb Salvia hispanica and to compare it with other species of sage (Salvia officinalis L. and Salvia sclarea L.). In fresh herbs, directly after drying (freeze-drying, natural drying, and drying at 30, 40, and 50 °C), and after storage (3, 6, and 12 months), the following analyses were performed: content of total carotenoids and total polyphenols, polyphenol profile (including 25 compounds), and antioxidant activity. Additionally, the basic chemical compositions of the herbs were analyzed. To the best of our knowledge, the content of total carotenoids and the quantitative polyphenol profile in Salvia hispanica and Salvia sclarea were evaluated for the first time. The obtained results showed that the barely investigated herb Salvia hispanica is rich in polyphenolic compounds and shows high antioxidant activity. In all the tested species, rosmarinic acid was the most abundant polyphenolic compound. The use of different drying methods allowed us to determine that freeze-drying was the most effective for preserving polyphenols and carotenoids. Long-term storage up to 12 months resulted in a gradual reduction in antioxidant activity and in the content of polyphenols and carotenoids.

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PCL and PCL/bioactive glass biomaterials as carriers for biologically active polyphenolic compounds: Comprehensive physicochemical and biological evaluation

Cited by 35 publications

References 73 publications

Polyphenol-Enriched Composite Bone Regeneration Materials: A Systematic Review of In Vitro Studies

Polyphenol-Enriched Composite Bone Regeneration Materials: A Systematic Review of In Vitro Studies

One-Pot Synthesis of Polyester-Based Linear and Graft Copolymers for Solid Polymer Electrolytes

The Changes in Bioactive Compounds and Antioxidant Activity of Chia (Salvia hispanica L.) Herb under Storage and Different Drying Conditions: A Comparison with Other Species of Sage

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