PCL-based nanofibers loaded with ciprofloxacin/cyclodextrin containers

Masoumi, Saeideh; Amiri, Sahar; Bahrami, S. Hajir

doi:10.1080/00405000.2017.1398625

Cited by 30 publications

(23 citation statements)

References 15 publications

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“…In addition, the CD enriched PCL fibers were used for encapsulation of small molecules like α-tocopherol [71], naproxen [72], sulfisoxazole [68], ciprofloxacin [73], as well as even large molecule (e.g., polymer or enzyme) [74,75,98,101,102]. Those studies were initiated to enhance the stability of active compounds against various environmental factors during delivery by entrapment them in PCL nanofibers.…”

Section: Polymeric Drug Delivery Systems From Cyclodextrin and Poly(εmentioning

confidence: 99%

Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

et al. 2020

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Cyclodextrins (CD) are a group of cyclic oligosaccharides with a cavity/specific structure that enables to form inclusion complexes (IC) with a variety of molecules through non-covalent host-guest interactions. By an elegant combination of CD with biocompatible, synthetic and natural polymers, different types of universal drug delivery systems with dynamic/reversible properties have been generated. This review presents the design of nano- and micro-carriers, hydrogels, and fibres based on the polymer/CD supramolecular systems highlighting their possible biomedical applications. Application of the most prominent hydrophobic aliphatic polyesters that exhibit biodegradability, represented by polylactide and polycaprolactone, is described first. Subsequently, particular attention is focused on materials obtained from hydrophilic polyethylene oxide. Moreover, examples are also presented for grafting of CD on polysaccharides. In summary, we show the application of host-guest interactions in multi-component functional biomaterials for controlled drug delivery.

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Section: Polymeric Drug Delivery Systems From Cyclodextrin and Poly(εmentioning

confidence: 99%

Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

et al. 2020

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“…Also, PCL can form biocompatible compounds with other polymers, while it can facilitate the desired degradation and release rate. [27,31,32] Single-polymer or multi polymers mixture with herbal extract, have many applications in the fields of wound healing, medicine, and drug delivery. [33][34][35] The porous structure of the membrane nanofibers is capable of removing excretion of the wound, controlling the water lost by evaporation from the wound surface, allowing to pass through and increasing the permeability of the fluids and also prevents the wound from the invention of external microorganism due to microscopic pores.…”

Section: Introductionmentioning

confidence: 99%

Electrospun PCL and PLA hybrid nanofibrous scaffolds containing Nigella sativa herbal extract for effective wound healing

Sharifi

Bahrami

Nejad

et al. 2020

J of Applied Polymer Sci

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Black seed (Nigella sativa [NS]) is used in traditional medicine as an antibacterial agent. In this study, novel hybrid scaffolds were manufactured from poly(ɛ‐caprolactone[PCL])/ Poly(lactic acid [PLA]) with NS extract by double‐nozzle electrospinning for wound healing application. Optimal conditions were found using response surface methodology including feed rate 0.8 ml/hr, voltage 20 kV and PLA 8% /PCL 10% concentrations. The effect of NS extract on the properties of the scaffold was evaluated by scanning electron microscopy, contact angle, and mechanical test. The PLA‐PCL/NS 20% beadles, and smooth nanofibrous web was obtained as the optimum scaffold with an average diameter of 638 ± 69 nm and the contact angle of 44°. In addition, the biological properties of the scaffolds such as antibacterial against Staphylococcus aureus (gram‐positive) and Escherichia coli (gram‐negative) bacteria, MTT assay, extract release, and cell growth (human mesenchymal stem cells) were examined. Incorporation of NS extract into the nanofibers caused to enhance the biological properties, cell viability and cell proliferation without toxicity.

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“…Anti-bacterial efficacies were determined according to AATCC 100-2004 test method. Anti-bacterial activities were observed when the bacteria inoculum was surrounded by a clear zone of growth inhibition, and evaluated by determining both the diameter of the bacteria colony and the diameter of the inhibition halo [6] [7].…”

Section: Anti-bacterial Efficienciesmentioning

confidence: 99%

“…Electrospinning was carried out by preparing PVA and IC solutions, PVA solutions (9% w/w) in distilled water. After formation, a homogenous solution, 0.037 g CDs/OFL inclusion complexes and 10% (w/w) citric acid (compared to the PVA weight) were added to the obtained PVA solution[7] [8] [9]. The solution was placed on a magnetic stirrer in ambient temperature at 250 rpm for 16 hours.…”

mentioning

confidence: 99%

“…the viscosity of the solution due to the increased entanglement between the chains. Also, the presence of α-CDin an electrospun solution caused the decrease in the solution conductivity due to the interactions between the molecules[6] [7] [8] [9][10]. The presence of an inclusion complex between the matrix phases decreases the conductivity of the polymer solution.…”

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confidence: 99%

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PVA Nanofibers Containing Ofloxacin-Cyclodextrin Inclusion Complex: Improve Optical Stability of Ofloxacin

Mehrizi¹,

Amiri²,

Bahrami³

2019

OJOPM

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Ofloxacin is an antibiotic with a wide range of activity against bacterial infections, but due to the high potential for toxicity when exposed to light, resolving this problem and further stabilizing the drug are among the posed challenges. Inclusion complex formation between α-cyclodextrin (α-CD), ofloxacin (OFL) and polyethylene glycol (PEG) was prepared via two methods to produce nanocontainers with desirable stability. The effect of PEG as compatible solubilizing agent and mixing condition (in ultrasonic bath) were investigated in formation of an inclusion complex between α-CD/OFL. Obtained complexes were examined by FTIR, H-NMR, SEM, EDX and UV which indicated the formation of an inclusion complex between α-CD/OFL, in turn, is a mixture of the cage and channel structures. Differences between 1 H-NMR, FTIR and XRD spectra of OFL, CDs and inclusion complex indicated the formation of α-CD/OFL and supramolecular containers in solid phase. These inclusion complexes loaded in PVA-based nanofibers for smart nanofibers with controlled release manner and higher stability of OFL. Obtained nanofiber showed that nanofibers containing CDs/OFL under sonic energy containing higher degree of OFL.

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PCL-based nanofibers loaded with ciprofloxacin/cyclodextrin containers

Cited by 30 publications

References 15 publications

Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

Electrospun PCL and PLA hybrid nanofibrous scaffolds containing Nigella sativa herbal extract for effective wound healing

PVA Nanofibers Containing Ofloxacin-Cyclodextrin Inclusion Complex: Improve Optical Stability of Ofloxacin

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