PCOS and hyperandrogenism in type 1 diabetes

Tibuni-Sanders, Susan; Nader, Shahla

doi:10.4236/ojog.2012.21015

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…About two-thirds of the patients received two insulin doses/day. Such a relatively intense insulin therapy was observed in type 1 diabetic patients [38]. Irrespective of this finding, intense insulin therapy is aimed at improving metabolic control in patients with type 1 diabetes [39].…”

Section: Table 3 Serum Vitamin D and Its Categories In Controls And Diabetic Patientsmentioning

confidence: 96%

Vitamin D and its relation to metabolic profile in type 1 diabetic patients from Gaza Strip

Yassin¹,

Alghora²,

Elhamalawi³

et al. 2020

Integr Food Nutr Metab

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Background: Recent research indicated the involvement of vitamin D in the pathophysiology of type 1 diabetes. In this study, we investigated serum vitamin D status and its relation to metabolic profile in type 1 diabetic patients from Gaza Strip. Methods:This study was a case-control design and included 44 type 1 diabetic patients as well as 44 non-diabetic controls. Patients and controls were matched for age, gender and body mass index (BMI). Data were obtained from questionnaire interview, and biochemical analysis of blood samples.Results: Serum vitamin D was significantly lower in diabetic patients compared to non-diabetic controls (34.1 ± 19.1 versus 43.9 ± 16.9 ng/dl, P=0.012). The number of patients having vitamin D deficient, insufficient and sufficient were 5 (11.4%), 20 (45.5%) and 19 (43.2%) compared to controls of 0 (0.0%), 13 (29.5%) and 31 (70.5%), respectively (χ 2 (corrected) =6.711, P=0.035). Serum glucose, glycated hemoglobin (HbA1c), serum insulin, alkaline phosphatase (ALP), cholesterol, triglycerides and low-density lipoprotein cholesterol (LDL-C) were significantly higher in patients than in controls whereas serum calcium was significantly lower in patients. Serum vitamin D showed significant negative correlations with HbA1c (r=-0.258, P=0.015), insulin (r=-0.257, P=0.016) and LDL-C (r=-0.281, P=0.008) whereas significant positive correlation was found with calcium (r=0.251, P=0.018). Conclusion:The relationship of vitamin D with HbA1c, LDL-C and calcium suggests that vitamin D and/or calcium system may represent a future target for the design of novel therapeutic strategies for patients with type 1 Diabetes.

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Section: Table 3 Serum Vitamin D and Its Categories In Controls And Diabetic Patientsmentioning

confidence: 96%

Vitamin D and its relation to metabolic profile in type 1 diabetic patients from Gaza Strip

Yassin¹,

Alghora²,

Elhamalawi³

et al. 2020

Integr Food Nutr Metab

View full text Add to dashboard Cite

show abstract

Comparative analysis of clinical symptoms and biochemical alterations in women with polycystic ovary syndrome: assessing the impact of type 1 diabetes versus non-diabetic controls

Yassin,

Laqqan,

Mwafy

et al. 2024

Middle East Fertil Soc J

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Background Women with type 1 diabetes depend on insulin injections throughout their life. However, the recommendation for strict metabolic control of diabetes requires the administration of supra-physiological doses of insulin, which might result in insulin-mediated stimulation of androgen synthesis. Hyperandrogenism in women with type 1 diabetes may be associated with polycystic ovary syndrome (PCOS). This study was performed to investigate PCOS and its associated clinical symptoms and biochemical alterations in women with type 1 diabetes in the Palestinian Territories. This retrospective cohort study consists of 50 women with type 1 diabetes and 50 apparently healthy non-diabetic controls. Questionnaire interviews were conducted. The diagnosis of PCOS was based on chronic anovulation and biochemical evidence of hyperandrogenism. Serum total testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and insulin were measured by ELISA. Results The mean waist-to-hip ratio and age at menarche were significantly higher in diabetic women than in non-diabetic controls (81.9 ± 7.9 and 13.9 ± 1.6 years vs. 78.8 ± 5.7 and 13.2 ± 1.2 years, and P = 0.045, P = 0.020, respectively). Oligomenorrhea, acanthosis nigricans, seborrhea, and hirsutism were more frequent in diabetics. The levels of total testosterone and insulin were significantly higher in diabetics (0.58 ± 0.11 ng/ml and 15.8 ± 12.4 mlU/ml vs. 0.44 ± 0.11 ng/ml and 10.8 ± 4.5 mlU/ml, P < 0.001 and P = 0.010, respectively). PCOS was present in 11 (22.0%) of diabetic women compared to 3 (6.0%) in non-diabetics (P = 0.044). Diabetic women with PCOS received higher doses of insulin than non-PCOS women (72.7 ± 23.9 vs. 55.0 ± 19.8 UI.cc/ml/day, P = 0.023). PCOS women showed more frequent oligomenorrhea (100% vs. 15.4%, P < 0.001) and higher levels of total testosterone and insulin (0.64 ± 0.09 and 23.1 ± 13.0 vs. 0.53 ± 0.11 and 14.1 ± 11.8, P = 0.023 and P = 0.041, respectively). PCOS cases were significantly more frequent in diabetic women receiving intensive insulin therapy than their counterparts with non-intensive insulin therapy (40.9% vs. 7.1%, P = 0.012). Conclusion Intensive insulin treatment in type 1 diabetes potentiates the development of PCOS and its related clinical and biochemical features particularly oligomenorrhea, hyperinsulinemia, and hyperandrogenemia.

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PCOS and hyperandrogenism in type 1 diabetes

Cited by 2 publications

References 21 publications

Vitamin D and its relation to metabolic profile in type 1 diabetic patients from Gaza Strip

Vitamin D and its relation to metabolic profile in type 1 diabetic patients from Gaza Strip

Comparative analysis of clinical symptoms and biochemical alterations in women with polycystic ovary syndrome: assessing the impact of type 1 diabetes versus non-diabetic controls

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