PCR-confirmed Legionella non-pneumophila meningoencephalitis

Perpoint, Thomas; Jamilloux, Yvan; Descloux, Élodie; Ferry, Tristan; Chidiac, C.; Lina, Gérard; Etienne, Jérôme; Jarraud, Sophie; Ader, Florence

doi:10.1016/j.medmal.2012.12.001

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…Raff et al report autopsies of 183 patients with Legionnaires disease where CNS findings of 158 subjects (86.3%) were normal, unremarkable, or nonspecific (10). Encephalitis, an inflammatory process of the brain, is a process that can potentially be a cause for neurological dysfunction but there has only been one documented case of meningoencephalitis with a confirmed positive Legionella PCR derived from lumbar puncture [8]. Standard CT and MRI are often normal concerning neuroimaging findings in neurologically complicated Legionella infection [8].…”

Section: Discussionmentioning

confidence: 99%

“…Encephalitis, an inflammatory process of the brain, is a process that can potentially be a cause for neurological dysfunction but there has only been one documented case of meningoencephalitis with a confirmed positive Legionella PCR derived from lumbar puncture [8]. Standard CT and MRI are often normal concerning neuroimaging findings in neurologically complicated Legionella infection [8]. Recently, there have been rare cases in which Legionnaires disease can have abnormalities on neuroimaging.…”

Section: Discussionmentioning

confidence: 99%

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Immune-Mediated Encephalopathy in the Setting of Legionnaires Disease: A Case Report and Review of the Literature

Abdel-Rahim

Chow

Singhal

2021

Asp Biomed Clin Case Rep

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Background: Legionnaires disease is the systemic manifestation of an infection by the gram-negative bacterium Legionella pneumophila. It most commonly presents with pneumonia, but can also cause extrapulmonary manifestations like cardiac, renal, gastrointestinal as well as neurologic symptoms like encephalopathy. It tends to occur in people who are elderly, immunocompromised and those with impaired respiratory (smokers) or cardiac (advanced heart failure) functions. The Legionella Urinary antigen is commonly used to diagnose Legionella infection. Almost half of the patients diagnosed with Legionnaires disease exhibit neurologic signs and symptoms. These neurologic abnormalities are usually not evident on neuroimaging, laboratory findings, and neuropathology.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Immune-Mediated Encephalopathy in the Setting of Legionnaires Disease: A Case Report and Review of the Literature

Abdel-Rahim

Chow

Singhal

2021

Asp Biomed Clin Case Rep

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“…The majority of instances have been documented in patients who are immunocompromised [40]. The extrapulmonary manifestations that have been reported comprise meningitis, brain abscesses, surgical site infections, prosthetic joint infection, osteomyelitis, cellulitis, cutaneous and soft tissue abscesses, myocarditis, pericarditis, native valve and prosthetic valve endocarditis, peritonitis, and pyelonephritis [41][42][43][44][45][46][47][48][49][50][51][52][53][54]. Extrapulmonary illness is diagnosed by detecting Legionella at the afflicted site, which is commonly done with a culture or a polymerase chain reaction [39].…”

Section: Legionellamentioning

confidence: 99%

“…Antigenuria develops over several days in the course of legionnaire's disease. As with early serological testing, if the test is undertaken too soon, it may be falsely negative [33,38,49,70].…”

Section: Diagnostic Approachmentioning

confidence: 99%

An Overview on Atypical Pneumonia Clinical Features and Management Approach

Al-Abbad¹,

Albarrak²,

Shuqayfah³

et al. 2022

Arch. Pharm. Pract

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Atypical pneumonia has evolved in recent decades to signify lower respiratory tract diseases caused by certain respiratory pathogens. These pathogens are distinguished clinically and radiologically from typical bacterial community-acquired pneumonia (CAP). The spectrum of such infections includes zoonotic and non-zoonotic transmissions, with the latter being more common. The tendency of extrapulmonary involvement, which is true for each kind of atypical CAP, distinguishes clinically from classical CAP. Therefore, clinical syndromic diagnosis is important for raising the index of suspicion and commencing appropriate empirical antibiotic therapy and prompting further diagnostic testing. We aimed to review the literature to enhance the understanding and awareness of atypical pneumonia. We reviewed the literature for atypical pneumonia; clinical manifestations, approach to diagnosis, and management. Articles were chosen from the PubMed database, and selected studies were subjected to a thorough review. Atypical organisms that cause pneumonia are more likely to cause systemic disorders with a wide range of extrapulmonary symptoms. On the other hand, some of them are difficult to culture and dangerous to isolate. As a result, clinical syndromic diagnosis is crucial for raising the index of suspicion, commencing appropriate empirical antibiotic therapy, and promoting specific diagnostic tests.

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Legionellosis

Johnson¹

2020

Infections of the Central Nervous System

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PCR-confirmed Legionella non-pneumophila meningoencephalitis

Cited by 5 publications

References 10 publications

Immune-Mediated Encephalopathy in the Setting of Legionnaires Disease: A Case Report and Review of the Literature

Immune-Mediated Encephalopathy in the Setting of Legionnaires Disease: A Case Report and Review of the Literature

An Overview on Atypical Pneumonia Clinical Features and Management Approach

Legionellosis

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