PCV Chemotherapy for Recurrent Oligodendrogliomas and Oligoastrocytomas

Soffietti, Riccardo; Rudà, Roberta; Bradac, Gianni Boris; Schiffer, Davide

doi:10.1097/00006123-199811000-00035

Cited by 149 publications

(84 citation statements)

References 39 publications

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“…Since Cairncross and McDonald observed that recurrent anaplastic oligodendrogliomas respond to chemotherapy, 3 several groups have reported on the chemosensitivity of both high-and low-grade oligodendrogliomas and mixed oligoastrocytomas. [4][5][6][7] As a result oligodendrogliomas are increasingly being treated with chemotherapy, in contrast to, for example, astrocytomas, which are substantially more resistant to chemotherapeutic agents. [4][5][6][7] In general brain tumors are pathologically diagnosed by analysis of tumor tissue obtained (invasively) by biopsy.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6][7] As a result oligodendrogliomas are increasingly being treated with chemotherapy, in contrast to, for example, astrocytomas, which are substantially more resistant to chemotherapeutic agents. [4][5][6][7] In general brain tumors are pathologically diagnosed by analysis of tumor tissue obtained (invasively) by biopsy. Both magnetic resonance imaging (MRI) and 1 H magnetic resonance spectroscopy (MRS) have proven to be powerful noninvasive tools for the characterization of brain tumors.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of oligodendrogliomas using short echo time ¹H MR spectroscopic imaging

Rijpkema¹,

Schuuring²,

Meulen³

et al. 2003

NMR in Biomedicine

117

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Oligodendroglial tumors may not be distinguished easily from other brain tumors based on clinical presentation and magnetic resonance imaging (MRI) alone. Identification of these tumors however may have therapeutic consequences. The purpose of this study was to characterize and identify oligodendrogliomas by their metabolic profile as measured by 1 H MR spectroscopic imaging (MRSI). Fifteen patients with oligodendroglial tumors (eight high-grade oligodendrogliomas, seven low-grade oligodendrogliomas) underwent MRI and short echo time 1 H MRSI examinations. Five main metabolites found in brain MR spectra were quantified and expressed as ratios of tumor to contralateral white matter tissue. The level of lipids plus lactate was also assessed in the tumor. For comparison six patients with a low grade astrocytoma were also included in the study. The metabolic profile of oligodendrogliomas showed a decreased level of N-acetylaspartate and increased levels of choline-containing compounds and glutamine plus glutamate compared with white matter. The level of glutamine plus glutamate was significantly higher in low-grade oligodendrogliomas than in low-grade astrocytomas and may serve as a metabolic marker in diagnosis and treatment planning. In high-grade oligodendrogliomas large resonances of lipids plus lactate were observed in contrast to low-grade tumors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of oligodendrogliomas using short echo time ¹H MR spectroscopic imaging

Rijpkema¹,

Schuuring²,

Meulen³

et al. 2003

NMR in Biomedicine

117

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“…5) PCV therapy is effective against both recurrent and newly diagnosed oligodendroglioma. 10,14) In our series, response to PMV therapy was observed in three patients with recurrent malignant oligodendroglial tumors previously treated by chemoradiation therapy. Three patients with recurrent tumor previously treated with radiation therapy also showed inhibition of tumor growth using PMV.…”

Section: Discussionmentioning

confidence: 62%

“…5,9) Responses to PCV have also been observed in both recurrent and newly diagnosed oligodendrogliomas with both low-grade and high-grade malignancy. 1,2,6,8,[10][11][12]14) The present study investigated the benefits and toxicity of combination chemotherapy (PMV) using procarbazine, ranimustine (MCNU), and vincristine, which is a replacement for PCV using agents available in Japan, in patients with both low-grade and high-grade oligodendrogliomas and oligoastrocytomas.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Adiuvant Therapy with Procarbazine, MCNU, and Vincristine for Oligodendroglial Tumors.

Wakabayashi

Kajita

Mizuno

et al. 2001

Neurol. Med. Chir.(Tokyo)

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An adjuvant chemotherapy regimen consisting of procarbazine, MCNU, and vincristine (PMV) was evaluated for the treatment of malignant oligodendroglial tumors. Ten patients with histologically proven oligodendroglial tumors were treated with PMV therapy and the effectiveness was assessed using magnetic resonance imaging. Four patients with primary tumors underwent PMV after radiation therapy, and six patients with recurrent tumors were treated using PMV only. Tumor response was defined as radiological evidence of mass size change after completion of three courses of PMV. Complete or partial responses (more than 50% reduction in tumor mass) were noted in six patients, and tumor growth stabilized in four patients. In particular, inhibition of tumor growth using PMV was achieved in three patients with recurrent oligodendroglial tumors, despite the initial response after chemoradiation therapy (interferon-b, MCNU, radiation) or nitrosourea chemotherapy (ACNU, MCNU). This PMV regimen (a modified PCV regimen using drugs available in Japan) is effective for treating malignant oligodendroglial tumors despite recurrence after other initial treatment procedures.

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“…12) Although no consensus on the routine use of chemotherapy in treating LGG, and especially astrocytomas, has been reached yet, its efficacy has been demonstrated in terms of clinical and radiological response either as initial treatment [2][3][4]8,10,13,15,24,27) or as salvage therapy after surgery and radiotherapy. 17,18,22,23,26,27) Complete neuroradiological disappearance of a tumor is infrequent, so good response is defined as volumetric regression or stabilization over time. Since progression of LGG towards highergrade malignancies has been associated with the accumulation of genetic abnormalities, 19,29) the difference in response to chemotherapy among histologically similar tumors is probably due to the heterogeneity in the genetic pattern of neoplastic cells.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Chemotherapy for Infiltrative Low-Grade Oligoastrocytoma: a Useful Strategy to Maximize Surgical Resection -Case Report-

Spena

Garbossa

Barletta

et al. 2010

Neurol. Med. Chir.(Tokyo)

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A 38-year-old woman presented with a large infiltrative left frontal low-grade glioma manifesting as partial seizures of the left arm and lower limb. First line chemotherapy with temozolomide reduced infiltration and volume, allowing subtotal surgical resection. The patient suffered postoperative supplementary motor area syndrome with right hemiparesis and mutism that resolved completely after approximately one month. She was able to return to her full-time job after 4 months. The residual tumor was stable, and the frequency of seizures had lessened dramatically at the last follow-up examination at 18 months. The present case demonstrates that this new therapeutic approach of chemotherapy followed by surgery can offer safer and more radical surgical resection, improving the quality of life of the patient.

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PCV Chemotherapy for Recurrent Oligodendrogliomas and Oligoastrocytomas

Abstract: These results suggest that chemotherapy with PCV is effective in the treatment of recurrent low-grade oligodendrogliomas and oligoastrocytomas.

Cited by 149 publications

References 39 publications

Characterization of oligodendrogliomas using short echo time ¹H MR spectroscopic imaging

Characterization of oligodendrogliomas using short echo time ¹H MR spectroscopic imaging

Efficacy of Adiuvant Therapy with Procarbazine, MCNU, and Vincristine for Oligodendroglial Tumors.

Preoperative Chemotherapy for Infiltrative Low-Grade Oligoastrocytoma: a Useful Strategy to Maximize Surgical Resection -Case Report-

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PCV Chemotherapy for Recurrent Oligodendrogliomas and Oligoastrocytomas

Abstract: These results suggest that chemotherapy with PCV is effective in the treatment of recurrent low-grade oligodendrogliomas and oligoastrocytomas.

Cited by 149 publications

References 39 publications

Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging

Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging

Efficacy of Adiuvant Therapy with Procarbazine, MCNU, and Vincristine for Oligodendroglial Tumors.

Preoperative Chemotherapy for Infiltrative Low-Grade Oligoastrocytoma: a Useful Strategy to Maximize Surgical Resection -Case Report-

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Characterization of oligodendrogliomas using short echo time ¹H MR spectroscopic imaging

Characterization of oligodendrogliomas using short echo time ¹H MR spectroscopic imaging