Pcv11 Point-of-Care Inr Monitoring Devices for Patients on Long-Term Oral Anticoagulation Therapy

Khan, T

doi:10.1016/s1098-3015(10)73773-6

Cited by 1 publication

(1 citation statement)

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“…There is an increasing requirement for reliable point‐of‐care devices for monitoring the effect of drugs that regulate blood coagulation (Khan, 2009). Since the first application of partial thromboplastin time (aPTT) for monitoring anticoagulant therapy (Struver & Bittner, 1962), it has become the most popular test for heparin dose monitoring (Gawoski et al.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of activated partial thromboplastin time (aPTT) reagents for application in biomedical diagnostic device development

Dudek

Harris

Killard

2010

Int J Lab Hematology

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UWE makes no representation or warranties of commercial utility, title, or fitness for a particular purpose or any other warranty, express or implied in respect of any material deposited. UWE makes no representation that the use of the materials will not infringe any patent, copyright, trademark or other property or proprietary rights. UWE accepts no liability for any infringement of intellectual property rights in any material deposited but will remove such material from public view pending investigation in the event of an allegation of any such infringement. Results: Reagents in all of the three forms tested (liquid, 24 h and 14 days) resulted in significant shortening of CTs in comparison to the non-activated plasma CT. Liquids returned more rapid CTs in comparison to dried reagents. Most reagents were more sensitive to heparin in dried, rather than in liquid form. Dried reagents based on kaolin as a surface activator were notably more effective in achieving short CT than others, while dried reagents composed of silica and synthetic phospholipids were the most sensitive to heparin. Conclusion:Two reagents, namely aPTT-SP and SynthASIL which are both based on synthetic phospholipids and silica, were identified as promising candidates for incorporation into point of care diagnostic device platforms as dried reagents.

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Section: Introductionmentioning

confidence: 99%