PD-1/PD-L1 Inhibitors-Induced Hypophysitis : A real-world retrospective cohort study

Abstract

Purpose:The main purposes and research question was to describe the clinical,laboratory, imageology and morphological characteristics of hypophysitis induced by PD-1/PD-L1 inhibitors,and its long-time course. Methods: This study was conducted at our hospital between January 2020 and October 2023,with longitudinal follow-up of patients 22 cases were included. Results: The onset time ranged from 13 days to 802 days,The main symptom of the patients were fatigue and poor appetite :about 16 cases complained of fatigue and 13 of poor appetite,other symptom have:nausea,vomiting,fever,chest and so on.All patients presented adrenocorticotropic hormone (ACTH) and Serum cortisol (COR) deficiency. Two patients showed Supersellae cistern herniation underwent pituitary MRI.All patients' symptoms improved after treatment with glucocorticoids. At last follow-up, None of patients serum cortisol and ACTH were recovered . Conclusion: Manifestations of PD-1/PD-L1 inhibitor-induced hypophysitis were nonspecific, serum hormone should be closely monitored in routine work.